| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATP2C2 | DCDC2 | ENSP00000262429 | ENSP00000367715 | ATPase, Ca++ transporting, type 2C, member 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium (By similarity) | doublecortin domain containing 2; May be involved in neuronal migration during development of the cerebral neocortex (By similarity) | 0.626 |
| ATP2C2 | DYX1C1 | ENSP00000262429 | ENSP00000323275 | ATPase, Ca++ transporting, type 2C, member 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium (By similarity) | dyslexia susceptibility 1 candidate 1; Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity | 0.555 |
| ATP2C2 | GCFC2 | ENSP00000262429 | ENSP00000318690 | ATPase, Ca++ transporting, type 2C, member 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium (By similarity) | GC-rich sequence DNA-binding factor 2; Factor that represses transcription. It binds to the GC- rich sequences (5’-GCGGGGC-3’) present in the epidermal growth factor receptor, beta-actin, and calcium-dependent protease promoters | 0.692 |
| ATP2C2 | KIAA0319 | ENSP00000262429 | ENSP00000367459 | ATPase, Ca++ transporting, type 2C, member 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium (By similarity) | KIAA0319 | 0.585 |
| ATP2C2 | MRPL19 | ENSP00000262429 | ENSP00000377486 | ATPase, Ca++ transporting, type 2C, member 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium (By similarity) | mitochondrial ribosomal protein L19 | 0.691 |
| CASC5 | GCFC2 | ENSP00000335463 | ENSP00000318690 | cancer susceptibility candidate 5; Performs two crucial functions during mitosis- it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Required for attachment of the kinetochores to the spindle microtubules. Directly links BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore | GC-rich sequence DNA-binding factor 2; Factor that represses transcription. It binds to the GC- rich sequences (5’-GCGGGGC-3’) present in the epidermal growth factor receptor, beta-actin, and calcium-dependent protease promoters | 0.688 |
| DCDC2 | ATP2C2 | ENSP00000367715 | ENSP00000262429 | doublecortin domain containing 2; May be involved in neuronal migration during development of the cerebral neocortex (By similarity) | ATPase, Ca++ transporting, type 2C, member 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium (By similarity) | 0.626 |
| DCDC2 | DYX1C1 | ENSP00000367715 | ENSP00000323275 | doublecortin domain containing 2; May be involved in neuronal migration during development of the cerebral neocortex (By similarity) | dyslexia susceptibility 1 candidate 1; Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity | 0.852 |
| DCDC2 | GCFC2 | ENSP00000367715 | ENSP00000318690 | doublecortin domain containing 2; May be involved in neuronal migration during development of the cerebral neocortex (By similarity) | GC-rich sequence DNA-binding factor 2; Factor that represses transcription. It binds to the GC- rich sequences (5’-GCGGGGC-3’) present in the epidermal growth factor receptor, beta-actin, and calcium-dependent protease promoters | 0.818 |
| DCDC2 | KIAA0319 | ENSP00000367715 | ENSP00000367459 | doublecortin domain containing 2; May be involved in neuronal migration during development of the cerebral neocortex (By similarity) | KIAA0319 | 0.909 |
| DCDC2 | MRPL19 | ENSP00000367715 | ENSP00000377486 | doublecortin domain containing 2; May be involved in neuronal migration during development of the cerebral neocortex (By similarity) | mitochondrial ribosomal protein L19 | 0.714 |
| DYX1C1 | ATP2C2 | ENSP00000323275 | ENSP00000262429 | dyslexia susceptibility 1 candidate 1; Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity | ATPase, Ca++ transporting, type 2C, member 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium (By similarity) | 0.555 |
| DYX1C1 | DCDC2 | ENSP00000323275 | ENSP00000367715 | dyslexia susceptibility 1 candidate 1; Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity | doublecortin domain containing 2; May be involved in neuronal migration during development of the cerebral neocortex (By similarity) | 0.852 |
| DYX1C1 | GCFC2 | ENSP00000323275 | ENSP00000318690 | dyslexia susceptibility 1 candidate 1; Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity | GC-rich sequence DNA-binding factor 2; Factor that represses transcription. It binds to the GC- rich sequences (5’-GCGGGGC-3’) present in the epidermal growth factor receptor, beta-actin, and calcium-dependent protease promoters | 0.811 |
| DYX1C1 | KIAA0319 | ENSP00000323275 | ENSP00000367459 | dyslexia susceptibility 1 candidate 1; Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity | KIAA0319 | 0.874 |
| DYX1C1 | MRPL19 | ENSP00000323275 | ENSP00000377486 | dyslexia susceptibility 1 candidate 1; Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity | mitochondrial ribosomal protein L19 | 0.611 |
| FLII | GCFC2 | ENSP00000324573 | ENSP00000318690 | flightless I homolog (Drosophila); May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling. Involved in early embryonic development (By similarity). May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation | GC-rich sequence DNA-binding factor 2; Factor that represses transcription. It binds to the GC- rich sequences (5’-GCGGGGC-3’) present in the epidermal growth factor receptor, beta-actin, and calcium-dependent protease promoters | 0.750 |
| FLII | LRRFIP1 | ENSP00000324573 | ENSP00000375857 | flightless I homolog (Drosophila); May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling. Involved in early embryonic development (By similarity). May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation | leucine rich repeat (in FLII) interacting protein 1; Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5’-AGCCCCCGGCG-3’) and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding | 0.998 |
| GCFC2 | ATP2C2 | ENSP00000318690 | ENSP00000262429 | GC-rich sequence DNA-binding factor 2; Factor that represses transcription. It binds to the GC- rich sequences (5’-GCGGGGC-3’) present in the epidermal growth factor receptor, beta-actin, and calcium-dependent protease promoters | ATPase, Ca++ transporting, type 2C, member 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium (By similarity) | 0.692 |
| GCFC2 | CASC5 | ENSP00000318690 | ENSP00000335463 | GC-rich sequence DNA-binding factor 2; Factor that represses transcription. It binds to the GC- rich sequences (5’-GCGGGGC-3’) present in the epidermal growth factor receptor, beta-actin, and calcium-dependent protease promoters | cancer susceptibility candidate 5; Performs two crucial functions during mitosis- it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Required for attachment of the kinetochores to the spindle microtubules. Directly links BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore | 0.688 |
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