| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATG4C | CCL1 | ENSP00000322159 | ENSP00000225842 | autophagy related 4C, cysteine peptidase; Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes | chemokine (C-C motif) ligand 1; Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8 | 0.725 |
| ATG4C | ENAM | ENSP00000322159 | ENSP00000379383 | autophagy related 4C, cysteine peptidase; Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes | enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation | 0.463 |
| ATG4C | LRRC25 | ENSP00000322159 | ENSP00000340983 | autophagy related 4C, cysteine peptidase; Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes | leucine rich repeat containing 25; May be involved in the activation of cells of innate and acquired immunity | 0.509 |
| ATG4C | MARCO | ENSP00000322159 | ENSP00000318916 | autophagy related 4C, cysteine peptidase; Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes | macrophage receptor with collagenous structure; Pattern recognition receptor (PRR). Binds Gram-positive and Gram-negative bacteria | 0.725 |
| ATG4C | NT5E | ENSP00000322159 | ENSP00000257770 | autophagy related 4C, cysteine peptidase; Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes | 5’-nucleotidase, ecto (CD73); Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Exhibits AMP-, NAD-, and NMN-nucleosidase activities | 0.580 |
| ATG4C | PDLIM1 | ENSP00000322159 | ENSP00000360305 | autophagy related 4C, cysteine peptidase; Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes | PDZ and LIM domain 1; Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton | 0.586 |
| ATG4C | PHB2 | ENSP00000322159 | ENSP00000441875 | autophagy related 4C, cysteine peptidase; Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes | prohibitin 2; Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging | 0.755 |
| ATG4C | SDE2 | ENSP00000322159 | ENSP00000272091 | autophagy related 4C, cysteine peptidase; Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes | SDE2 telomere maintenance homolog (S. pombe) | 0.416 |
| ATG4C | SPTAN1 | ENSP00000322159 | ENSP00000361824 | autophagy related 4C, cysteine peptidase; Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes | spectrin, alpha, non-erythrocytic 1 | 0.726 |
| CCL1 | ATG4C | ENSP00000225842 | ENSP00000322159 | chemokine (C-C motif) ligand 1; Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8 | autophagy related 4C, cysteine peptidase; Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes | 0.725 |
| CCL1 | ENAM | ENSP00000225842 | ENSP00000379383 | chemokine (C-C motif) ligand 1; Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8 | enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation | 0.513 |
| CCL1 | LRRC25 | ENSP00000225842 | ENSP00000340983 | chemokine (C-C motif) ligand 1; Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8 | leucine rich repeat containing 25; May be involved in the activation of cells of innate and acquired immunity | 0.568 |
| CCL1 | MARCO | ENSP00000225842 | ENSP00000318916 | chemokine (C-C motif) ligand 1; Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8 | macrophage receptor with collagenous structure; Pattern recognition receptor (PRR). Binds Gram-positive and Gram-negative bacteria | 0.751 |
| CCL1 | NT5E | ENSP00000225842 | ENSP00000257770 | chemokine (C-C motif) ligand 1; Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8 | 5’-nucleotidase, ecto (CD73); Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Exhibits AMP-, NAD-, and NMN-nucleosidase activities | 0.724 |
| CCL1 | PDLIM1 | ENSP00000225842 | ENSP00000360305 | chemokine (C-C motif) ligand 1; Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8 | PDZ and LIM domain 1; Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton | 0.756 |
| CCL1 | PHB2 | ENSP00000225842 | ENSP00000441875 | chemokine (C-C motif) ligand 1; Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8 | prohibitin 2; Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging | 0.812 |
| CCL1 | SDE2 | ENSP00000225842 | ENSP00000272091 | chemokine (C-C motif) ligand 1; Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8 | SDE2 telomere maintenance homolog (S. pombe) | 0.654 |
| CCL1 | SPTAN1 | ENSP00000225842 | ENSP00000361824 | chemokine (C-C motif) ligand 1; Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8 | spectrin, alpha, non-erythrocytic 1 | 0.816 |
| ENAM | ATG4C | ENSP00000379383 | ENSP00000322159 | enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation | autophagy related 4C, cysteine peptidase; Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes | 0.463 |
| ENAM | CCL1 | ENSP00000379383 | ENSP00000225842 | enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation | chemokine (C-C motif) ligand 1; Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8 | 0.513 |
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