| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| HSP90AA1 | PINX1 | ENSP00000335153 | ENSP00000318966 | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | PIN2/TERF1 interacting, telomerase inhibitor 1; Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor | 0.905 |
| HSP90AA1 | PTGES3 | ENSP00000335153 | ENSP00000262033 | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | prostaglandin E synthase 3 (cytosolic); Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor- mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes | 0.999 |
| HSP90AA1 | TERT | ENSP00000335153 | ENSP00000309572 | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA- dependent extension of 3’-chromosomal termini with the 6- n [...] | 0.999 |
| HSP90AA1 | TFIP11 | ENSP00000335153 | ENSP00000383892 | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | tuftelin interacting protein 11; May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix. May also be involved in pre-mRNA splicing (By similarity) | 0.499 |
| MAK16 | NOP2 | ENSP00000353246 | ENSP00000382392 | MAK16 homolog (S. cerevisiae) | NOP2 nucleolar protein homolog (yeast); May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation. May act as ribosomal RNA methyltransferase | 0.836 |
| MAK16 | PINX1 | ENSP00000353246 | ENSP00000318966 | MAK16 homolog (S. cerevisiae) | PIN2/TERF1 interacting, telomerase inhibitor 1; Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor | 0.909 |
| MAK16 | RBM28 | ENSP00000353246 | ENSP00000223073 | MAK16 homolog (S. cerevisiae) | RNA binding motif protein 28; Nucleolar component of the spliceosomal ribonucleoprotein complexes | 0.924 |
| MAK16 | RPF1 | ENSP00000353246 | ENSP00000359688 | MAK16 homolog (S. cerevisiae) | ribosome production factor 1 homolog (S. cerevisiae); May be required for ribosome biogenesis | 0.913 |
| MAK16 | SURF6 | ENSP00000353246 | ENSP00000361092 | MAK16 homolog (S. cerevisiae) | surfeit 6; Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly (By similarity) | 0.754 |
| NOP2 | MAK16 | ENSP00000382392 | ENSP00000353246 | NOP2 nucleolar protein homolog (yeast); May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation. May act as ribosomal RNA methyltransferase | MAK16 homolog (S. cerevisiae) | 0.836 |
| NOP2 | PINX1 | ENSP00000382392 | ENSP00000318966 | NOP2 nucleolar protein homolog (yeast); May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation. May act as ribosomal RNA methyltransferase | PIN2/TERF1 interacting, telomerase inhibitor 1; Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor | 0.856 |
| NOP2 | RBM28 | ENSP00000382392 | ENSP00000223073 | NOP2 nucleolar protein homolog (yeast); May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation. May act as ribosomal RNA methyltransferase | RNA binding motif protein 28; Nucleolar component of the spliceosomal ribonucleoprotein complexes | 0.999 |
| NOP2 | RPF1 | ENSP00000382392 | ENSP00000359688 | NOP2 nucleolar protein homolog (yeast); May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation. May act as ribosomal RNA methyltransferase | ribosome production factor 1 homolog (S. cerevisiae); May be required for ribosome biogenesis | 0.993 |
| NOP2 | SURF6 | ENSP00000382392 | ENSP00000361092 | NOP2 nucleolar protein homolog (yeast); May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation. May act as ribosomal RNA methyltransferase | surfeit 6; Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly (By similarity) | 0.674 |
| PINX1 | HSP90AA1 | ENSP00000318966 | ENSP00000335153 | PIN2/TERF1 interacting, telomerase inhibitor 1; Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | 0.905 |
| PINX1 | MAK16 | ENSP00000318966 | ENSP00000353246 | PIN2/TERF1 interacting, telomerase inhibitor 1; Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor | MAK16 homolog (S. cerevisiae) | 0.909 |
| PINX1 | NOP2 | ENSP00000318966 | ENSP00000382392 | PIN2/TERF1 interacting, telomerase inhibitor 1; Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor | NOP2 nucleolar protein homolog (yeast); May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation. May act as ribosomal RNA methyltransferase | 0.856 |
| PINX1 | PTGES3 | ENSP00000318966 | ENSP00000262033 | PIN2/TERF1 interacting, telomerase inhibitor 1; Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor | prostaglandin E synthase 3 (cytosolic); Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor- mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes | 0.904 |
| PINX1 | RBM28 | ENSP00000318966 | ENSP00000223073 | PIN2/TERF1 interacting, telomerase inhibitor 1; Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor | RNA binding motif protein 28; Nucleolar component of the spliceosomal ribonucleoprotein complexes | 0.877 |
| PINX1 | RPF1 | ENSP00000318966 | ENSP00000359688 | PIN2/TERF1 interacting, telomerase inhibitor 1; Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor | ribosome production factor 1 homolog (S. cerevisiae); May be required for ribosome biogenesis | 0.871 |
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