node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTN2 | CAMK2B | ENSP00000355537 | ENSP00000379098 | actinin, alpha 2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | calcium/calmodulin-dependent protein kinase II beta | 0.914 |
ACTN2 | CAMK2D | ENSP00000355537 | ENSP00000339740 | actinin, alpha 2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | calcium/calmodulin-dependent protein kinase II delta; Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart f [...] | 0.962 |
ACTN2 | CAMK2G | ENSP00000355537 | ENSP00000319060 | actinin, alpha 2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | calcium/calmodulin-dependent protein kinase II gamma | 0.960 |
ACTN2 | DLG1 | ENSP00000355537 | ENSP00000345731 | actinin, alpha 2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | discs, large homolog 1 (Drosophila) | 0.635 |
ACTN2 | DLG4 | ENSP00000355537 | ENSP00000293813 | actinin, alpha 2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | discs, large homolog 4 (Drosophila); Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity) | 0.962 |
ACTN2 | GRIN1 | ENSP00000355537 | ENSP00000360608 | actinin, alpha 2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | glutamate receptor, ionotropic, N-methyl D-aspartate 1 | 0.961 |
ACTN2 | GRIN2A | ENSP00000355537 | ENSP00000332549 | actinin, alpha 2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | glutamate receptor, ionotropic, N-methyl D-aspartate 2A; NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits | 0.911 |
ACTN2 | GRIN2B | ENSP00000355537 | ENSP00000279593 | actinin, alpha 2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | glutamate receptor, ionotropic, N-methyl D-aspartate 2B; NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity) | 0.965 |
ACTN2 | GRIN2D | ENSP00000355537 | ENSP00000263269 | actinin, alpha 2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | glutamate receptor, ionotropic, N-methyl D-aspartate 2D; NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine | 0.908 |
CAMK2B | ACTN2 | ENSP00000379098 | ENSP00000355537 | calcium/calmodulin-dependent protein kinase II beta | actinin, alpha 2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | 0.914 |
CAMK2B | CAMK2D | ENSP00000379098 | ENSP00000339740 | calcium/calmodulin-dependent protein kinase II beta | calcium/calmodulin-dependent protein kinase II delta; Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart f [...] | 0.980 |
CAMK2B | CAMK2G | ENSP00000379098 | ENSP00000319060 | calcium/calmodulin-dependent protein kinase II beta | calcium/calmodulin-dependent protein kinase II gamma | 0.955 |
CAMK2B | DLG1 | ENSP00000379098 | ENSP00000345731 | calcium/calmodulin-dependent protein kinase II beta | discs, large homolog 1 (Drosophila) | 0.963 |
CAMK2B | DLG4 | ENSP00000379098 | ENSP00000293813 | calcium/calmodulin-dependent protein kinase II beta | discs, large homolog 4 (Drosophila); Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity) | 0.970 |
CAMK2B | GRIN1 | ENSP00000379098 | ENSP00000360608 | calcium/calmodulin-dependent protein kinase II beta | glutamate receptor, ionotropic, N-methyl D-aspartate 1 | 0.973 |
CAMK2B | GRIN2A | ENSP00000379098 | ENSP00000332549 | calcium/calmodulin-dependent protein kinase II beta | glutamate receptor, ionotropic, N-methyl D-aspartate 2A; NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits | 0.992 |
CAMK2B | GRIN2B | ENSP00000379098 | ENSP00000279593 | calcium/calmodulin-dependent protein kinase II beta | glutamate receptor, ionotropic, N-methyl D-aspartate 2B; NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity) | 0.990 |
CAMK2B | GRIN2D | ENSP00000379098 | ENSP00000263269 | calcium/calmodulin-dependent protein kinase II beta | glutamate receptor, ionotropic, N-methyl D-aspartate 2D; NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine | 0.953 |
CAMK2B | STAT1 | ENSP00000379098 | ENSP00000354394 | calcium/calmodulin-dependent protein kinase II beta | signal transducer and activator of transcription 1, 91kDa | 0.900 |
CAMK2D | ACTN2 | ENSP00000339740 | ENSP00000355537 | calcium/calmodulin-dependent protein kinase II delta; Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart f [...] | actinin, alpha 2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | 0.962 |