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DLG4 DLG4 GRIN1 GRIN1 ACTN2 ACTN2 DLG1 DLG1 GRIN2D GRIN2D GRIN2A GRIN2A CAMK2B CAMK2B CAMK2G CAMK2G GRIN2B GRIN2B CAMK2D CAMK2D STAT1 STAT1
"CAMK2G" - calcium/calmodulin-dependent protein kinase II gamma in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Known Interactions
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from curated databases
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experimentally determined
Predicted Interactions
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fusion edge
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gene co-occurrence
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textmining
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co-expression
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protein homology
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[Homology]
Score
CAMK2Gcalcium/calmodulin-dependent protein kinase II gamma (556 aa)    
Predicted Functional Partners:
GRIN2B
glutamate receptor, ionotropic, N-methyl D-aspartate 2B; NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity) (1484 aa)
        score_image score_image score_image   0.996
GRIN1
glutamate receptor, ionotropic, N-methyl D-aspartate 1 (943 aa)
        score_image score_image score_image   0.987
GRIN2A
glutamate receptor, ionotropic, N-methyl D-aspartate 2A; NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits (1464 aa)
        score_image score_image score_image   0.983
DLG4
discs, large homolog 4 (Drosophila); Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity) (767 aa)
        score_image score_image score_image   0.971
DLG1
discs, large homolog 1 (Drosophila) (926 aa)
        score_image score_image score_image   0.963
ACTN2
actinin, alpha 2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (894 aa)
        score_image score_image score_image   0.960
CAMK2D
calcium/calmodulin-dependent protein kinase II delta; Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart f [...] (499 aa)
    score_image   score_image score_image score_image score_image 0.957
STAT1
signal transducer and activator of transcription 1, 91kDa (750 aa)
        score_image score_image score_image   0.956
CAMK2B
calcium/calmodulin-dependent protein kinase II beta (666 aa)
        score_image score_image score_image score_image 0.955
GRIN2D
glutamate receptor, ionotropic, N-methyl D-aspartate 2D; NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine (1336 aa)
        score_image score_image score_image   0.954
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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