CYBRD1 protein (Homo sapiens) - STRING network view

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CYBRD1

cytochrome b reductase 1 (286 aa)

Predicted Functional Partners:

SLC11A2

0.987

SLC40A1

0.838

HEPH

0.824

HAMP

0.809

STX4

0.739

MT-CYB

0.727

TFR2

0.725

SLC39A1

0.681

HFE

0.662

SLC11A1

0.650

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CYBRD1	HAMP	ENSP00000319141	ENSP00000222304	cytochrome b reductase 1	hepcidin antimicrobial peptide; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity)	0.809
CYBRD1	HEPH	ENSP00000319141	ENSP00000430620	cytochrome b reductase 1	hephaestin; May function as a ferroxidase for ferrous (II) to ferric ion (III) conversion and may be involved in copper transport and homeostasis. Implicated in iron homeostasis and may mediate iron efflux associated to ferroportin 1	0.824
CYBRD1	HFE	ENSP00000319141	ENSP00000417404	cytochrome b reductase 1	hemochromatosis	0.662
CYBRD1	MT-CYB	ENSP00000319141	ENSP00000354554	cytochrome b reductase 1	mitochondrially encoded cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)	0.727
CYBRD1	SLC11A1	ENSP00000319141	ENSP00000233202	cytochrome b reductase 1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1; Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the catio [...]	0.650
CYBRD1	SLC11A2	ENSP00000319141	ENSP00000378364	cytochrome b reductase 1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	0.987
CYBRD1	SLC39A1	ENSP00000319141	ENSP00000309710	cytochrome b reductase 1	solute carrier family 39 (zinc transporter), member 1; Mediates zinc uptake. May function as a major endogenous zinc uptake transporter in many cells of the body. Responsible for the rapid uptake and accumulation of physiologically effective zinc in prostate cells	0.681
CYBRD1	SLC40A1	ENSP00000319141	ENSP00000261024	cytochrome b reductase 1	solute carrier family 40 (iron-regulated transporter), member 1; May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin)	0.838
CYBRD1	STX4	ENSP00000319141	ENSP00000317714	cytochrome b reductase 1	syntaxin 4; Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones	0.739
CYBRD1	TFR2	ENSP00000319141	ENSP00000223051	cytochrome b reductase 1	transferrin receptor 2; Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation	0.725
HAMP	CYBRD1	ENSP00000222304	ENSP00000319141	hepcidin antimicrobial peptide; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity)	cytochrome b reductase 1	0.809
HAMP	HEPH	ENSP00000222304	ENSP00000430620	hepcidin antimicrobial peptide; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity)	hephaestin; May function as a ferroxidase for ferrous (II) to ferric ion (III) conversion and may be involved in copper transport and homeostasis. Implicated in iron homeostasis and may mediate iron efflux associated to ferroportin 1	0.483
HAMP	HFE	ENSP00000222304	ENSP00000417404	hepcidin antimicrobial peptide; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity)	hemochromatosis	0.953
HAMP	MT-CYB	ENSP00000222304	ENSP00000354554	hepcidin antimicrobial peptide; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity)	mitochondrially encoded cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)	0.453
HAMP	SLC11A2	ENSP00000222304	ENSP00000378364	hepcidin antimicrobial peptide; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity)	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	0.918
HAMP	SLC39A1	ENSP00000222304	ENSP00000309710	hepcidin antimicrobial peptide; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity)	solute carrier family 39 (zinc transporter), member 1; Mediates zinc uptake. May function as a major endogenous zinc uptake transporter in many cells of the body. Responsible for the rapid uptake and accumulation of physiologically effective zinc in prostate cells	0.608
HAMP	SLC40A1	ENSP00000222304	ENSP00000261024	hepcidin antimicrobial peptide; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity)	solute carrier family 40 (iron-regulated transporter), member 1; May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin)	0.973
HAMP	TFR2	ENSP00000222304	ENSP00000223051	hepcidin antimicrobial peptide; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity)	transferrin receptor 2; Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation	0.836
HEPH	CYBRD1	ENSP00000430620	ENSP00000319141	hephaestin; May function as a ferroxidase for ferrous (II) to ferric ion (III) conversion and may be involved in copper transport and homeostasis. Implicated in iron homeostasis and may mediate iron efflux associated to ferroportin 1	cytochrome b reductase 1	0.824
HEPH	HAMP	ENSP00000430620	ENSP00000222304	hephaestin; May function as a ferroxidase for ferrous (II) to ferric ion (III) conversion and may be involved in copper transport and homeostasis. Implicated in iron homeostasis and may mediate iron efflux associated to ferroportin 1	hepcidin antimicrobial peptide; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity)	0.483

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