| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| FAF1 | HSPA4 | ENSP00000360843 | ENSP00000302961 | Fas (TNFRSF6) associated factor 1; Potentiates but cannot initiate FAS-induced apoptosis | heat shock 70kDa protein 4 | 0.955 |
| FAF1 | HSPA8 | ENSP00000360843 | ENSP00000227378 | Fas (TNFRSF6) associated factor 1; Potentiates but cannot initiate FAS-induced apoptosis | heat shock 70kDa protein 8; Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19- CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex | 0.628 |
| FAF1 | NLRP12 | ENSP00000360843 | ENSP00000319377 | Fas (TNFRSF6) associated factor 1; Potentiates but cannot initiate FAS-induced apoptosis | NLR family, pyrin domain containing 12; May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK | 0.828 |
| HSP90AA1 | HSPA4 | ENSP00000335153 | ENSP00000302961 | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | heat shock 70kDa protein 4 | 0.999 |
| HSP90AA1 | HSPA8 | ENSP00000335153 | ENSP00000227378 | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | heat shock 70kDa protein 8; Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19- CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex | 0.999 |
| HSP90AA1 | IRAK1 | ENSP00000335153 | ENSP00000358997 | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | interleukin-1 receptor-associated kinase 1; Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor- signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiqui [...] | 0.680 |
| HSP90AA1 | NLRP12 | ENSP00000335153 | ENSP00000319377 | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | NLR family, pyrin domain containing 12; May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK | 0.936 |
| HSPA4 | FAF1 | ENSP00000302961 | ENSP00000360843 | heat shock 70kDa protein 4 | Fas (TNFRSF6) associated factor 1; Potentiates but cannot initiate FAS-induced apoptosis | 0.955 |
| HSPA4 | HSP90AA1 | ENSP00000302961 | ENSP00000335153 | heat shock 70kDa protein 4 | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | 0.999 |
| HSPA4 | HSPA8 | ENSP00000302961 | ENSP00000227378 | heat shock 70kDa protein 4 | heat shock 70kDa protein 8; Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19- CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex | 0.977 |
| HSPA4 | NLRP12 | ENSP00000302961 | ENSP00000319377 | heat shock 70kDa protein 4 | NLR family, pyrin domain containing 12; May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK | 0.576 |
| HSPA8 | FAF1 | ENSP00000227378 | ENSP00000360843 | heat shock 70kDa protein 8; Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19- CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex | Fas (TNFRSF6) associated factor 1; Potentiates but cannot initiate FAS-induced apoptosis | 0.628 |
| HSPA8 | HSP90AA1 | ENSP00000227378 | ENSP00000335153 | heat shock 70kDa protein 8; Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19- CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | 0.999 |
| HSPA8 | HSPA4 | ENSP00000227378 | ENSP00000302961 | heat shock 70kDa protein 8; Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19- CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex | heat shock 70kDa protein 4 | 0.977 |
| HSPA8 | NLRP12 | ENSP00000227378 | ENSP00000319377 | heat shock 70kDa protein 8; Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19- CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex | NLR family, pyrin domain containing 12; May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK | 0.645 |
| IRAK1 | HSP90AA1 | ENSP00000358997 | ENSP00000335153 | interleukin-1 receptor-associated kinase 1; Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor- signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiqui [...] | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | 0.680 |
| IRAK1 | NLRP12 | ENSP00000358997 | ENSP00000319377 | interleukin-1 receptor-associated kinase 1; Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor- signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiqui [...] | NLR family, pyrin domain containing 12; May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK | 0.648 |
| MEFV | NLRP12 | ENSP00000219596 | ENSP00000319377 | Mediterranean fever; Probably controls the inflammatory response in myelomonocytic cells at the level of the cytoskeleton organization | NLR family, pyrin domain containing 12; May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK | 0.654 |
| MEFV | PYCARD | ENSP00000219596 | ENSP00000247470 | Mediterranean fever; Probably controls the inflammatory response in myelomonocytic cells at the level of the cytoskeleton organization | PYD and CARD domain containing; Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also caspase-9 in a probable cell type-specific manner. Involved in activation of the mitochondrial apoptotic pathway, promotes caspase-8-dependent proteolytic maturation of BID independently of FADD in certain cell types and also mediates mitochondrial translocation of BAX and activates BAX-dependent apoptosis coupled to activation of caspase-9, -2 and -3. Involved in macrophage pyroptosis, a caspase-1-dependent inflammatory [...] | 0.989 |
| NLRC4 | NLRP12 | ENSP00000354159 | ENSP00000319377 | NLR family, CARD domain containing 4; Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis | NLR family, pyrin domain containing 12; May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK | 0.581 |
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