IGDCC4 protein (Homo sapiens) - STRING network view

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IGDCC4

immunoglobulin superfamily, DCC subclass, member 4 (1250 aa)

Predicted Functional Partners:

NTNG1

0.819

NTNG2

0.813

NTN3

0.811

NTN1

0.806

NTN5

0.798

VWA2

0.701

IQSEC2

0.691

IQSEC3

0.691

IQSEC1

0.691

EVX1

0.667

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EVX1	IGDCC4	ENSP00000419266	ENSP00000319623	even-skipped homeobox 1; May play a role in the specification of neuronal cell types	immunoglobulin superfamily, DCC subclass, member 4	0.667
IGDCC4	EVX1	ENSP00000319623	ENSP00000419266	immunoglobulin superfamily, DCC subclass, member 4	even-skipped homeobox 1; May play a role in the specification of neuronal cell types	0.667
IGDCC4	IQSEC1	ENSP00000319623	ENSP00000273221	immunoglobulin superfamily, DCC subclass, member 4	IQ motif and Sec7 domain 1; In addition to accelerate GTP gamma S binding by ARFs of all three classes, it appears to function preferentially as a guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin	0.691
IGDCC4	IQSEC2	ENSP00000319623	ENSP00000379712	immunoglobulin superfamily, DCC subclass, member 4	IQ motif and Sec7 domain 2	0.691
IGDCC4	IQSEC3	ENSP00000319623	ENSP00000315662	immunoglobulin superfamily, DCC subclass, member 4	IQ motif and Sec7 domain 3; Acts as a guanine nucleotide exchange factor (GEF) for ARF1	0.691
IGDCC4	NTN1	ENSP00000319623	ENSP00000173229	immunoglobulin superfamily, DCC subclass, member 4	netrin 1; Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis	0.806
IGDCC4	NTN3	ENSP00000319623	ENSP00000293973	immunoglobulin superfamily, DCC subclass, member 4	netrin 3; Netrins control guidance of CNS commissural axons and peripheral motor axons (By similarity)	0.811
IGDCC4	NTN5	ENSP00000319623	ENSP00000270235	immunoglobulin superfamily, DCC subclass, member 4	netrin 5	0.798
IGDCC4	NTNG1	ENSP00000319623	ENSP00000359085	immunoglobulin superfamily, DCC subclass, member 4	netrin G1; Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites	0.819
IGDCC4	NTNG2	ENSP00000319623	ENSP00000376921	immunoglobulin superfamily, DCC subclass, member 4	netrin G2; Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites	0.813
IGDCC4	VWA2	ENSP00000319623	ENSP00000298715	immunoglobulin superfamily, DCC subclass, member 4	von Willebrand factor A domain containing 2	0.701
IQSEC1	IGDCC4	ENSP00000273221	ENSP00000319623	IQ motif and Sec7 domain 1; In addition to accelerate GTP gamma S binding by ARFs of all three classes, it appears to function preferentially as a guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin	immunoglobulin superfamily, DCC subclass, member 4	0.691
IQSEC1	NTN1	ENSP00000273221	ENSP00000173229	IQ motif and Sec7 domain 1; In addition to accelerate GTP gamma S binding by ARFs of all three classes, it appears to function preferentially as a guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin	netrin 1; Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis	0.631
IQSEC1	NTN3	ENSP00000273221	ENSP00000293973	IQ motif and Sec7 domain 1; In addition to accelerate GTP gamma S binding by ARFs of all three classes, it appears to function preferentially as a guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin	netrin 3; Netrins control guidance of CNS commissural axons and peripheral motor axons (By similarity)	0.624
IQSEC1	NTN5	ENSP00000273221	ENSP00000270235	IQ motif and Sec7 domain 1; In addition to accelerate GTP gamma S binding by ARFs of all three classes, it appears to function preferentially as a guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin	netrin 5	0.602
IQSEC1	NTNG1	ENSP00000273221	ENSP00000359085	IQ motif and Sec7 domain 1; In addition to accelerate GTP gamma S binding by ARFs of all three classes, it appears to function preferentially as a guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin	netrin G1; Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites	0.607
IQSEC1	NTNG2	ENSP00000273221	ENSP00000376921	IQ motif and Sec7 domain 1; In addition to accelerate GTP gamma S binding by ARFs of all three classes, it appears to function preferentially as a guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin	netrin G2; Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites	0.602
IQSEC2	IGDCC4	ENSP00000379712	ENSP00000319623	IQ motif and Sec7 domain 2	immunoglobulin superfamily, DCC subclass, member 4	0.691
IQSEC2	NTN1	ENSP00000379712	ENSP00000173229	IQ motif and Sec7 domain 2	netrin 1; Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis	0.624
IQSEC2	NTN3	ENSP00000379712	ENSP00000293973	IQ motif and Sec7 domain 2	netrin 3; Netrins control guidance of CNS commissural axons and peripheral motor axons (By similarity)	0.624

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