DMRTA1 protein (Homo sapiens) - STRING network view

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Size

small nodes:
protein of unknown 3D structure

large nodes:
some 3D structure is known or predicted

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

DMRTA1

DMRT-like family A1 (504 aa)

Predicted Functional Partners:

EBF2

0.680

EBF4

0.674

EBF3

0.674

EBF1

0.674

HOXD13

0.590

HOXA10

0.584

HOXC11

0.575

ENSG00000257184

0.575

HOXD12

0.575

HOXA9

0.575

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DMRTA1	EBF1	ENSP00000319651	ENSP00000322898	DMRT-like family A1	early B-cell factor 1; Transcriptional activator which recognizes variations of the palindromic sequence 5’-ATTCCCNNGGGAATT-3’ (By similarity)	0.674
DMRTA1	EBF2	ENSP00000319651	ENSP00000430241	DMRT-like family A1	early B-cell factor 2; Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with the Wnt- responsive LEF1/CTNNB1 pathway. Recognizes variations of the palindromic sequence 5’-ATTCCCNNGGGAATT-3’ (By similarity)	0.680
DMRTA1	EBF3	ENSP00000319651	ENSP00000357637	DMRT-like family A1	early B-cell factor 3; Transcriptional activator which recognizes variations of the palindromic sequence 5’-ATTCCCNNGGGAATT-3’ (By similarity)	0.674
DMRTA1	EBF4	ENSP00000319651	ENSP00000370022	DMRT-like family A1	early B-cell factor 4; Transcriptional factor which recognizes variations of the palindromic sequence 5’-ATTCCCNNGGGAATT-3’ (By similarity)	0.674
DMRTA1	ENSG00000257184	ENSP00000319651	ENSP00000421799	DMRT-like family A1	Uncharacterized protein	0.575
DMRTA1	HOXA10	ENSP00000319651	ENSP00000283921	DMRT-like family A1	homeobox A10; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to the DNA sequence 5’-AA[AT]TTTTATTAC-3’	0.584
DMRTA1	HOXA9	ENSP00000319651	ENSP00000343619	DMRT-like family A1	homeobox A9; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation	0.575
DMRTA1	HOXC11	ENSP00000319651	ENSP00000446680	DMRT-like family A1	homeobox C11; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to a promoter element of the lactase-phlorizin hydrolase gene	0.575
DMRTA1	HOXD12	ENSP00000319651	ENSP00000385586	DMRT-like family A1	homeobox D12; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis	0.575
DMRTA1	HOXD13	ENSP00000319651	ENSP00000376322	DMRT-like family A1	homeobox D13; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis	0.590
EBF1	DMRTA1	ENSP00000322898	ENSP00000319651	early B-cell factor 1; Transcriptional activator which recognizes variations of the palindromic sequence 5’-ATTCCCNNGGGAATT-3’ (By similarity)	DMRT-like family A1	0.674
EBF2	DMRTA1	ENSP00000430241	ENSP00000319651	early B-cell factor 2; Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with the Wnt- responsive LEF1/CTNNB1 pathway. Recognizes variations of the palindromic sequence 5’-ATTCCCNNGGGAATT-3’ (By similarity)	DMRT-like family A1	0.680
EBF3	DMRTA1	ENSP00000357637	ENSP00000319651	early B-cell factor 3; Transcriptional activator which recognizes variations of the palindromic sequence 5’-ATTCCCNNGGGAATT-3’ (By similarity)	DMRT-like family A1	0.674
EBF4	DMRTA1	ENSP00000370022	ENSP00000319651	early B-cell factor 4; Transcriptional factor which recognizes variations of the palindromic sequence 5’-ATTCCCNNGGGAATT-3’ (By similarity)	DMRT-like family A1	0.674
ENSG00000257184	DMRTA1	ENSP00000421799	ENSP00000319651	Uncharacterized protein	DMRT-like family A1	0.575
HOXA10	DMRTA1	ENSP00000283921	ENSP00000319651	homeobox A10; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to the DNA sequence 5’-AA[AT]TTTTATTAC-3’	DMRT-like family A1	0.584
HOXA9	DMRTA1	ENSP00000343619	ENSP00000319651	homeobox A9; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation	DMRT-like family A1	0.575
HOXC11	DMRTA1	ENSP00000446680	ENSP00000319651	homeobox C11; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to a promoter element of the lactase-phlorizin hydrolase gene	DMRT-like family A1	0.575
HOXD12	DMRTA1	ENSP00000385586	ENSP00000319651	homeobox D12; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis	DMRT-like family A1	0.575
HOXD13	DMRTA1	ENSP00000376322	ENSP00000319651	homeobox D13; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis	DMRT-like family A1	0.590

Textmining

Cooccurrence

Experiments

Neighborhood

Databases

Fusion

Coexpression

© STRING Consortium 2017

Credits

Access

Info

About