| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABL1 | GRB2 | ENSP00000361423 | ENSP00000339007 | c-abl oncogene 1, non-receptor tyrosine kinase; Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN ( [...] | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | 0.999 |
| ABL1 | ST5 | ENSP00000361423 | ENSP00000319678 | c-abl oncogene 1, non-receptor tyrosine kinase; Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN ( [...] | suppression of tumorigenicity 5 | 0.825 |
| AIM1 | SDCBP | ENSP00000358062 | ENSP00000260130 | absent in melanoma 1; May function as suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton | syndecan binding protein (syntenin); Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway | 0.700 |
| AIM1 | ST13 | ENSP00000358062 | ENSP00000216218 | absent in melanoma 1; May function as suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein); One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity) | 0.620 |
| AIM1 | ST18 | ENSP00000358062 | ENSP00000276480 | absent in melanoma 1; May function as suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton | suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein); Repressor that binds to DNA sequences containing a bipartite element consisting of a direct repeat of the sequence 5’-AAAGTTT-3’ separated by 2-9 nucleotides. Represses basal transcription activity from target promoters (By similarity). Inhibits colony formation in cultured breast cancer cells | 0.444 |
| AIM1 | ST5 | ENSP00000358062 | ENSP00000319678 | absent in melanoma 1; May function as suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton | suppression of tumorigenicity 5 | 0.738 |
| GRB2 | ABL1 | ENSP00000339007 | ENSP00000361423 | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | c-abl oncogene 1, non-receptor tyrosine kinase; Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN ( [...] | 0.999 |
| GRB2 | ST5 | ENSP00000339007 | ENSP00000319678 | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | suppression of tumorigenicity 5 | 0.687 |
| LMO1 | SCUBE2 | ENSP00000338207 | ENSP00000429969 | LIM domain only 1 (rhombotin 1); May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors | signal peptide, CUB domain, EGF-like 2 | 0.678 |
| LMO1 | ST5 | ENSP00000338207 | ENSP00000319678 | LIM domain only 1 (rhombotin 1); May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors | suppression of tumorigenicity 5 | 0.682 |
| SCUBE2 | LMO1 | ENSP00000429969 | ENSP00000338207 | signal peptide, CUB domain, EGF-like 2 | LIM domain only 1 (rhombotin 1); May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors | 0.678 |
| SCUBE2 | ST5 | ENSP00000429969 | ENSP00000319678 | signal peptide, CUB domain, EGF-like 2 | suppression of tumorigenicity 5 | 0.860 |
| SDCBP | AIM1 | ENSP00000260130 | ENSP00000358062 | syndecan binding protein (syntenin); Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway | absent in melanoma 1; May function as suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton | 0.700 |
| SDCBP | ST5 | ENSP00000260130 | ENSP00000319678 | syndecan binding protein (syntenin); Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway | suppression of tumorigenicity 5 | 0.704 |
| ST13 | AIM1 | ENSP00000216218 | ENSP00000358062 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein); One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity) | absent in melanoma 1; May function as suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton | 0.620 |
| ST13 | ST14 | ENSP00000216218 | ENSP00000278742 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein); One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity) | suppression of tumorigenicity 14 (colon carcinoma); Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site | 0.793 |
| ST13 | ST18 | ENSP00000216218 | ENSP00000276480 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein); One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity) | suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein); Repressor that binds to DNA sequences containing a bipartite element consisting of a direct repeat of the sequence 5’-AAAGTTT-3’ separated by 2-9 nucleotides. Represses basal transcription activity from target promoters (By similarity). Inhibits colony formation in cultured breast cancer cells | 0.722 |
| ST13 | ST5 | ENSP00000216218 | ENSP00000319678 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein); One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity) | suppression of tumorigenicity 5 | 0.726 |
| ST14 | ST13 | ENSP00000278742 | ENSP00000216218 | suppression of tumorigenicity 14 (colon carcinoma); Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein); One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity) | 0.793 |
| ST14 | ST18 | ENSP00000278742 | ENSP00000276480 | suppression of tumorigenicity 14 (colon carcinoma); Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site | suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein); Repressor that binds to DNA sequences containing a bipartite element consisting of a direct repeat of the sequence 5’-AAAGTTT-3’ separated by 2-9 nucleotides. Represses basal transcription activity from target promoters (By similarity). Inhibits colony formation in cultured breast cancer cells | 0.580 |
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