node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BAG2 | BAG4 | ENSP00000359727 | ENSP00000287322 | BCL2-associated athanogene 2; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release | BCL2-associated athanogene 4; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling | 0.628 |
BAG2 | C8orf4 | ENSP00000359727 | ENSP00000319914 | BCL2-associated athanogene 2; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release | chromosome 8 open reading frame 4; May decrease apoptosis | 0.440 |
BAG4 | BAG2 | ENSP00000287322 | ENSP00000359727 | BCL2-associated athanogene 4; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling | BCL2-associated athanogene 2; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release | 0.628 |
BAG4 | C8orf4 | ENSP00000287322 | ENSP00000319914 | BCL2-associated athanogene 4; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling | chromosome 8 open reading frame 4; May decrease apoptosis | 0.682 |
BAG4 | LSM1 | ENSP00000287322 | ENSP00000310596 | BCL2-associated athanogene 4; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling | LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae); Plays a role in replication-dependent histone mRNA degradation. Binds specifically to the 3’-terminal U-tract of U6 snRNA | 0.610 |
BAG4 | PPAPDC1B | ENSP00000287322 | ENSP00000392553 | BCL2-associated athanogene 4; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling | phosphatidic acid phosphatase type 2 domain containing 1B; Displays magnesium-independent phosphatidate phosphatase activity in vitro. Catalyzes the conversion of phosphatidic acid to diacylglycerol. May be a metastatic suppressor for hepatocellular carcinoma | 0.476 |
BAG4 | PROSC | ENSP00000287322 | ENSP00000333551 | BCL2-associated athanogene 4; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling | proline synthetase co-transcribed homolog (bacterial) | 0.430 |
C8orf4 | BAG2 | ENSP00000319914 | ENSP00000359727 | chromosome 8 open reading frame 4; May decrease apoptosis | BCL2-associated athanogene 2; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release | 0.440 |
C8orf4 | BAG4 | ENSP00000319914 | ENSP00000287322 | chromosome 8 open reading frame 4; May decrease apoptosis | BCL2-associated athanogene 4; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling | 0.682 |
C8orf4 | CCR6 | ENSP00000319914 | ENSP00000339393 | chromosome 8 open reading frame 4; May decrease apoptosis | chemokine (C-C motif) receptor 6; Receptor for a C-C type chemokine. Binds to MIP-3- alpha/LARC and subsequently transduces a signal by increasing the intracellular calcium ions level | 0.606 |
C8orf4 | LSM1 | ENSP00000319914 | ENSP00000310596 | chromosome 8 open reading frame 4; May decrease apoptosis | LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae); Plays a role in replication-dependent histone mRNA degradation. Binds specifically to the 3’-terminal U-tract of U6 snRNA | 0.680 |
C8orf4 | PPAPDC1B | ENSP00000319914 | ENSP00000392553 | chromosome 8 open reading frame 4; May decrease apoptosis | phosphatidic acid phosphatase type 2 domain containing 1B; Displays magnesium-independent phosphatidate phosphatase activity in vitro. Catalyzes the conversion of phosphatidic acid to diacylglycerol. May be a metastatic suppressor for hepatocellular carcinoma | 0.407 |
C8orf4 | PRMT2 | ENSP00000319914 | ENSP00000347906 | chromosome 8 open reading frame 4; May decrease apoptosis | protein arginine methyltransferase 2; Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1- dependent manner). May be involved in growth regulation | 0.508 |
C8orf4 | PROSC | ENSP00000319914 | ENSP00000333551 | chromosome 8 open reading frame 4; May decrease apoptosis | proline synthetase co-transcribed homolog (bacterial) | 0.412 |
C8orf4 | TRPS1 | ENSP00000319914 | ENSP00000379065 | chromosome 8 open reading frame 4; May decrease apoptosis | trichorhinophalangeal syndrome I; Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes | 0.457 |
C8orf4 | ZNF185 | ENSP00000319914 | ENSP00000440847 | chromosome 8 open reading frame 4; May decrease apoptosis | zinc finger protein 185 (LIM domain) | 0.459 |
CCR6 | C8orf4 | ENSP00000339393 | ENSP00000319914 | chemokine (C-C motif) receptor 6; Receptor for a C-C type chemokine. Binds to MIP-3- alpha/LARC and subsequently transduces a signal by increasing the intracellular calcium ions level | chromosome 8 open reading frame 4; May decrease apoptosis | 0.606 |
CCR6 | TRPS1 | ENSP00000339393 | ENSP00000379065 | chemokine (C-C motif) receptor 6; Receptor for a C-C type chemokine. Binds to MIP-3- alpha/LARC and subsequently transduces a signal by increasing the intracellular calcium ions level | trichorhinophalangeal syndrome I; Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes | 0.748 |
LSM1 | BAG4 | ENSP00000310596 | ENSP00000287322 | LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae); Plays a role in replication-dependent histone mRNA degradation. Binds specifically to the 3’-terminal U-tract of U6 snRNA | BCL2-associated athanogene 4; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling | 0.610 |
LSM1 | C8orf4 | ENSP00000310596 | ENSP00000319914 | LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae); Plays a role in replication-dependent histone mRNA degradation. Binds specifically to the 3’-terminal U-tract of U6 snRNA | chromosome 8 open reading frame 4; May decrease apoptosis | 0.680 |