NKX2-6 protein (Homo sapiens) - STRING network view

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NKX2-6

NK2 homeobox 6; In conjunction with NKX2-5, may play a role in both pharyngeal and cardiac embryonic development (By similarity) (301 aa)

Predicted Functional Partners:

CRELD1

0.725

TBX1

0.714

FGF8

0.708

FGF10

0.691

PORCN

0.682

MEF2A

0.665

MEF2C

0.664

GATA4

0.631

FGF2

0.613

PBX3

0.600

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CRELD1	GATA4	ENSP00000321856	ENSP00000334458	cysteine-rich with EGF-like domains 1	GATA binding protein 4; Transcriptional activator. Binds to the consensus sequence 5’-AGATAG-3’. Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement	0.511
CRELD1	NKX2-6	ENSP00000321856	ENSP00000320089	cysteine-rich with EGF-like domains 1	NK2 homeobox 6; In conjunction with NKX2-5, may play a role in both pharyngeal and cardiac embryonic development (By similarity)	0.725
FGF10	FGF2	ENSP00000264664	ENSP00000264498	fibroblast growth factor 10; Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing	fibroblast growth factor 2 (basic)	0.918
FGF10	GATA4	ENSP00000264664	ENSP00000334458	fibroblast growth factor 10; Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing	GATA binding protein 4; Transcriptional activator. Binds to the consensus sequence 5’-AGATAG-3’. Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement	0.453
FGF10	MEF2A	ENSP00000264664	ENSP00000346389	fibroblast growth factor 10; Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing	myocyte enhancer factor 2A	0.580
FGF10	MEF2C	ENSP00000264664	ENSP00000340874	fibroblast growth factor 10; Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing	myocyte enhancer factor 2C; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle- specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platel [...]	0.598
FGF10	NKX2-6	ENSP00000264664	ENSP00000320089	fibroblast growth factor 10; Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing	NK2 homeobox 6; In conjunction with NKX2-5, may play a role in both pharyngeal and cardiac embryonic development (By similarity)	0.691
FGF2	FGF10	ENSP00000264498	ENSP00000264664	fibroblast growth factor 2 (basic)	fibroblast growth factor 10; Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing	0.918
FGF2	GATA4	ENSP00000264498	ENSP00000334458	fibroblast growth factor 2 (basic)	GATA binding protein 4; Transcriptional activator. Binds to the consensus sequence 5’-AGATAG-3’. Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement	0.581
FGF2	MEF2A	ENSP00000264498	ENSP00000346389	fibroblast growth factor 2 (basic)	myocyte enhancer factor 2A	0.613
FGF2	MEF2C	ENSP00000264498	ENSP00000340874	fibroblast growth factor 2 (basic)	myocyte enhancer factor 2C; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle- specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platel [...]	0.599
FGF2	NKX2-6	ENSP00000264498	ENSP00000320089	fibroblast growth factor 2 (basic)	NK2 homeobox 6; In conjunction with NKX2-5, may play a role in both pharyngeal and cardiac embryonic development (By similarity)	0.613
FGF8	GATA4	ENSP00000321797	ENSP00000334458	fibroblast growth factor 8 (androgen-induced); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system	GATA binding protein 4; Transcriptional activator. Binds to the consensus sequence 5’-AGATAG-3’. Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement	0.525
FGF8	MEF2A	ENSP00000321797	ENSP00000346389	fibroblast growth factor 8 (androgen-induced); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system	myocyte enhancer factor 2A	0.597
FGF8	MEF2C	ENSP00000321797	ENSP00000340874	fibroblast growth factor 8 (androgen-induced); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system	myocyte enhancer factor 2C; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle- specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platel [...]	0.597
FGF8	NKX2-6	ENSP00000321797	ENSP00000320089	fibroblast growth factor 8 (androgen-induced); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system	NK2 homeobox 6; In conjunction with NKX2-5, may play a role in both pharyngeal and cardiac embryonic development (By similarity)	0.708
FGF8	TBX1	ENSP00000321797	ENSP00000331791	fibroblast growth factor 8 (androgen-induced); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system	T-box 1; Probable transcriptional regulator involved in developmental processes. Is required for normal development of the pharyngeal arch arteries (By similarity)	0.467
GATA4	CRELD1	ENSP00000334458	ENSP00000321856	GATA binding protein 4; Transcriptional activator. Binds to the consensus sequence 5’-AGATAG-3’. Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement	cysteine-rich with EGF-like domains 1	0.511
GATA4	FGF10	ENSP00000334458	ENSP00000264664	GATA binding protein 4; Transcriptional activator. Binds to the consensus sequence 5’-AGATAG-3’. Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement	fibroblast growth factor 10; Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing	0.453
GATA4	FGF2	ENSP00000334458	ENSP00000264498	GATA binding protein 4; Transcriptional activator. Binds to the consensus sequence 5’-AGATAG-3’. Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement	fibroblast growth factor 2 (basic)	0.581

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