GHRHR protein (Homo sapiens) - STRING network view

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GHRHR

growth hormone releasing hormone receptor; Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion (423 aa)

Predicted Functional Partners:

GHRH

0.999

GNAS

0.988

VIP

0.954

GCG

0.944

POMC

0.943

POU1F1

0.942

PTH

0.936

NPS

0.936

CRH

0.933

PTHLH

0.918

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CRH	GCG	ENSP00000276571	ENSP00000387662	corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland	glucagon; Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life	0.963
CRH	GHRH	ENSP00000276571	ENSP00000237527	corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland	growth hormone releasing hormone; GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone	0.980
CRH	GHRHR	ENSP00000276571	ENSP00000320180	corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland	growth hormone releasing hormone receptor; Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion	0.933
CRH	GNAS	ENSP00000276571	ENSP00000360141	corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland	GNAS complex locus; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(s) protein is involved in hormonal regulation of adenylate cyclase- it activates the cyclase in response to beta-adrenergic stimuli. XLas isoforms interact with the same set of receptors as Gnas isoforms (By similarity)	0.918
CRH	NPS	ENSP00000276571	ENSP00000381105	corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland	neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (By similarity)	0.987
CRH	POMC	ENSP00000276571	ENSP00000264708	corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland	proopiomelanocortin; ACTH stimulates the adrenal glands to release cortisol	0.998
CRH	PTH	ENSP00000276571	ENSP00000282091	corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland	parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2- deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells	0.949
CRH	PTHLH	ENSP00000276571	ENSP00000379213	corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland	parathyroid hormone-like hormone; Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of t [...]	0.929
CRH	VIP	ENSP00000276571	ENSP00000356213	corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland	vasoactive intestinal peptide; VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder	0.968
GCG	CRH	ENSP00000387662	ENSP00000276571	glucagon; Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life	corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland	0.963
GCG	GHRH	ENSP00000387662	ENSP00000237527	glucagon; Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life	growth hormone releasing hormone; GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone	0.971
GCG	GHRHR	ENSP00000387662	ENSP00000320180	glucagon; Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life	growth hormone releasing hormone receptor; Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion	0.944
GCG	GNAS	ENSP00000387662	ENSP00000360141	glucagon; Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life	GNAS complex locus; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(s) protein is involved in hormonal regulation of adenylate cyclase- it activates the cyclase in response to beta-adrenergic stimuli. XLas isoforms interact with the same set of receptors as Gnas isoforms (By similarity)	0.932
GCG	NPS	ENSP00000387662	ENSP00000381105	glucagon; Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life	neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (By similarity)	0.971
GCG	POMC	ENSP00000387662	ENSP00000264708	glucagon; Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life	proopiomelanocortin; ACTH stimulates the adrenal glands to release cortisol	0.980
GCG	PTH	ENSP00000387662	ENSP00000282091	glucagon; Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life	parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2- deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells	0.974
GCG	PTHLH	ENSP00000387662	ENSP00000379213	glucagon; Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life	parathyroid hormone-like hormone; Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of t [...]	0.929
GCG	VIP	ENSP00000387662	ENSP00000356213	glucagon; Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life	vasoactive intestinal peptide; VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder	0.925
GHRH	CRH	ENSP00000237527	ENSP00000276571	growth hormone releasing hormone; GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone	corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland	0.980
GHRH	GCG	ENSP00000237527	ENSP00000387662	growth hormone releasing hormone; GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone	glucagon; Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life	0.971

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