node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADCY5 | ADORA1 | ENSP00000419361 | ENSP00000308549 | adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase | adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase | 0.909 |
ADCY5 | ADORA3 | ENSP00000419361 | ENSP00000358730 | adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase | adenosine A3 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. Possible role in reproduction (By similarity) | 0.900 |
ADCY5 | GPR17 | ENSP00000419361 | ENSP00000272644 | adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase | G protein-coupled receptor 17; Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia | 0.900 |
ADCY5 | KNG1 | ENSP00000419361 | ENSP00000265023 | adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase | kininogen 1; (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin- induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects- (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation [...] | 0.911 |
ADCY5 | LPAR1 | ENSP00000419361 | ENSP00000351755 | adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase | lysophosphatidic acid receptor 1; Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Stimulates phospholipase C (PLC) activity in a manner that is dependent on RALA activation | 0.900 |
ADCY5 | NMUR1 | ENSP00000419361 | ENSP00000305877 | adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase | neuromedin U receptor 1; Receptor for the neuromedin-U and neuromedin-S neuropeptides (By similarity) | 0.900 |
ADCY5 | OXGR1 | ENSP00000419361 | ENSP00000298440 | adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase | oxoglutarate (alpha-ketoglutarate) receptor 1; Receptor for alpha-ketoglutarate. Seems to act exclusively through a G(q)-mediated pathway (By similarity) | 0.900 |
ADCY5 | P2RY13 | ENSP00000419361 | ENSP00000320376 | adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase | purinergic receptor P2Y, G-protein coupled, 13; Receptor for ADP. Coupled to G(i)-proteins. May play a role in hematopoiesis and the immune system | 0.914 |
ADCY5 | P2RY4 | ENSP00000419361 | ENSP00000363643 | adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase | pyrimidinergic receptor P2Y, G-protein coupled, 4; Receptor for UTP and UDP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. Not activated by ATP or ADP | 0.900 |
ADCY5 | SUCNR1 | ENSP00000419361 | ENSP00000355156 | adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase | succinate receptor 1; Receptor for succinate | 0.903 |
ADORA1 | ADCY5 | ENSP00000308549 | ENSP00000419361 | adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase | adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase | 0.909 |
ADORA1 | ADORA3 | ENSP00000308549 | ENSP00000358730 | adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase | adenosine A3 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. Possible role in reproduction (By similarity) | 0.921 |
ADORA1 | GPR17 | ENSP00000308549 | ENSP00000272644 | adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase | G protein-coupled receptor 17; Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia | 0.903 |
ADORA1 | KNG1 | ENSP00000308549 | ENSP00000265023 | adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase | kininogen 1; (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin- induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects- (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation [...] | 0.956 |
ADORA1 | LPAR1 | ENSP00000308549 | ENSP00000351755 | adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase | lysophosphatidic acid receptor 1; Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Stimulates phospholipase C (PLC) activity in a manner that is dependent on RALA activation | 0.902 |
ADORA1 | NMUR1 | ENSP00000308549 | ENSP00000305877 | adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase | neuromedin U receptor 1; Receptor for the neuromedin-U and neuromedin-S neuropeptides (By similarity) | 0.904 |
ADORA1 | OXGR1 | ENSP00000308549 | ENSP00000298440 | adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase | oxoglutarate (alpha-ketoglutarate) receptor 1; Receptor for alpha-ketoglutarate. Seems to act exclusively through a G(q)-mediated pathway (By similarity) | 0.929 |
ADORA1 | P2RY13 | ENSP00000308549 | ENSP00000320376 | adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase | purinergic receptor P2Y, G-protein coupled, 13; Receptor for ADP. Coupled to G(i)-proteins. May play a role in hematopoiesis and the immune system | 0.930 |
ADORA1 | P2RY4 | ENSP00000308549 | ENSP00000363643 | adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase | pyrimidinergic receptor P2Y, G-protein coupled, 4; Receptor for UTP and UDP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. Not activated by ATP or ADP | 0.909 |
ADORA1 | SUCNR1 | ENSP00000308549 | ENSP00000355156 | adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase | succinate receptor 1; Receptor for succinate | 0.906 |