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SLC43A1 SLC43A1 SLC6A14 SLC6A14 SLC3A2 SLC3A2 SLC3A1 SLC3A1 SLC16A10 SLC16A10 SLC7A8 SLC7A8 SLC7A14 SLC7A14 DIO2 DIO2 DIO3 DIO3 SLC16A2 SLC16A2 D3 D3
"SLC7A8" - solute carrier family 7 (amino acid transporter light chain, L system), member 8 in Homo sapiens
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SLC7A8solute carrier family 7 (amino acid transporter light chain, L system), member 8; Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylme [...] (535 aa)    
Predicted Functional Partners:
SLC3A2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2; Required for the function of light chain amino-acid transporters. Involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. Involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids [...] (631 aa)
        score_image score_image score_image   0.996
SLC3A1
solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1; Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system B(0,+)-like activity). May function as an activator of SLC7A9 and be involved in the high-affinity reabsorption of cystine in the kidney tubule (685 aa)
        score_image   score_image   0.873
SLC43A1
solute carrier family 43, member 1; Sodium-independent, high affinity transport of large neutral amino acids. Has narrower substrate selectivity compared to SLC7A5 and SLC7A8 and mainly transports branched-chain amino acids and phenylalanine. Plays a role in the development of human prostate cancer, from prostatic intraepithelial neoplasia to invasive prostate cancer (559 aa)
            score_image   0.812
D3
type III iodothyronine deiodinase ; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine) into RT3 (3,3’,5’-triiodothyronine) and of T3 (3,5,3’-triiodothyronine) into T2 (3,3’-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development (304 aa)
            score_image   0.687
DIO3
deiodinase, iodothyronine, type III (278 aa)
            score_image   0.683
SLC6A14
solute carrier family 6 (amino acid transporter), member 14; Mediates the uptake of a broad range of neutral and cationic amino acids (with the exception of proline) in a Na(+)/Cl(-)-dependent manner (642 aa)
            score_image   0.666
SLC7A14
solute carrier family 7 (orphan transporter), member 14 (771 aa)
    score_image       score_image   0.651
SLC16A10
solute carrier family 16, member 10 (aromatic amino acid transporter); Sodium-independent transporter that mediates the update of aromatic acid. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells (By similarity) (515 aa)
        score_image   score_image   0.625
DIO2
deiodinase, iodothyronine, type II; Responsible for the deiodination of T4 (3,5,3’,5’- tetraiodothyronine) into T3 (3,5,3’-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development (309 aa)
            score_image   0.609
SLC16A2
solute carrier family 16, member 2 (thyroid hormone transporter); Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr (By similarity) (613 aa)
            score_image   0.606
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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