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UBE2E3 UBE2E3 MARCH5 MARCH5 AMFR AMFR BNIP1 BNIP1 UBC UBC RNF121 RNF121 CDK12 CDK12 RNF185 RNF185 DVL2 DVL2 YIPF2 YIPF2 RNF175 RNF175
"RNF185" - ring finger protein 185 in Homo sapiens
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protein of unknown 3D structure
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RNF185ring finger protein 185; Mitochondrial E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating ’Lys-63’-linked polyubiquitination of BNIP1 (192 aa)    
Predicted Functional Partners:
UBC
ubiquitin C (685 aa)
        score_image       0.977
BNIP1
BCL2/adenovirus E1B 19kDa interacting protein 1 (271 aa)
        score_image   score_image   0.954
DVL2
dishevelled, dsh homolog 2 (Drosophila); Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes (By similarity) (736 aa)
        score_image   score_image   0.924
RNF175
ring finger protein 175 (328 aa)
            score_image   0.736
UBE2E3
ubiquitin-conjugating enzyme E2E 3; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes ’Lys- 11’- and ’Lys-48’-, as well as ’Lys-63’-linked polyubiquitination. Participates in the regulation of transepithelial sodium transport in renal cells. May be involved in cell growth arrest (207 aa)
        score_image       0.725
RNF121
ring finger protein 121 (327 aa)
            score_image   0.704
CDK12
cyclin-dependent kinase 12; Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogn inhibitors (1490 aa)
            score_image   0.660
YIPF2
Yip1 domain family, member 2 (316 aa)
        score_image   score_image   0.648
AMFR
autocrine motility factor receptor, E3 ubiquitin protein ligase; E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97- AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97- AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released f [...] (643 aa)
            score_image   0.574
MARCH5
membrane-associated ring finger (C3HC4) 5; Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1 (278 aa)
            score_image   0.560
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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