Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
|
Your Input:
|
Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
|||||
 | C5orf4 | chromosome 5 open reading frame 4 (333 aa) | ||||||||||||
Predicted Functional Partners:
| ||||||||||||||
 | TM7SF2 | transmembrane 7 superfamily member 2; Involved in the conversion of lanosterol to cholesterol (418 aa) |
 |
|
|
|
0.968 | |||||||
 | DHCR24 | 24-dehydrocholesterol reductase; Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis (516 aa) |
|
|
|
0.915 | ||||||||
 | AGMO | alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes (445 aa) |
|
|
|
0.912 | ||||||||
 | SQLE | squalene epoxidase; Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway (574 aa) |
|
|
|
0.880 | ||||||||
 | FDFT1 | farnesyl-diphosphate farnesyltransferase 1 (417 aa) |
|
|
|
0.860 | ||||||||
 | C14orf1 | chromosome 14 open reading frame 1 (140 aa) |
|
|
|
0.859 | ||||||||
 | CYP8B1 | cytochrome P450, family 8, subfamily B, polypeptide 1; Involved in bile acid synthesis and is responsible for the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7 alpha, 12 alpha-dihydroxy-4-cholesten-3-one. Responsible for the balance between formation of cholic acid and chenodeoxycholic acid. Has a rather broad substrate specificity including a number of 7-alpha- hydroxylated C27 steroids (501 aa) |
|
|
|
0.845 | ||||||||
 | CYP7B1 | cytochrome P450, family 7, subfamily B, polypeptide 1 (506 aa) |
|
|
|
0.845 | ||||||||
 | CYP7A1 | cytochrome P450, family 7, subfamily A, polypeptide 1; Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis (504 aa) |
|
|
|
0.845 | ||||||||
 | CYP39A1 | cytochrome P450, family 39, subfamily A, polypeptide 1; Involved in the bile acid metabolism. Has a preference for 24-hydroxycholesterol, and converts it into a 7-alpha- hydroxylated product (469 aa) |
|
|
|
0.845 | ||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
Share
