Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier ), member 36 (311 aa) | ||||||||||||
Predicted Functional Partners:
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 | LAMTOR1 | late endosomal/lysosomal adaptor, MAPK and MTOR activator 1; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible [...] (161 aa) |
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0.603 | ||||||||||
 | RBMS2 | RNA binding motif, single stranded interacting protein 2 (407 aa) |
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0.583 | ||||||||||
 | SLC25A28 | solute carrier family 25 (mitochondrial iron transporter), member 28; Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly in non-erythroid cells. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (By similarity) (364 aa) |
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0.571 | ||||||||
 | SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37; Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (By similarity) (338 aa) |
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0.568 | ||||||||
 | TTC19 | tetratricopeptide repeat domain 19; Mitochondrial protein required for formation of the mitochondrial complex III (PubMed-21278747). May also be required for the abcission step in cytokinesis, possibly regulating the ESCRT-III complex via its interaction with CHMP4B (PubMed-20208530). However, the involvement in cytokinesis requires additional experimental evidence (501 aa) |
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0.530 | |||||||||
 | PFDN1 | prefoldin subunit 1; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (122 aa) |
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0.516 | ||||||||||
 | RBMS3 | RNA binding motif, single stranded interacting protein 3; Binds poly(A) and poly(U) oligoribonucleotides (437 aa) |
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0.455 | ||||||||||
 | RBMS1 | RNA binding motif, single stranded interacting protein 1; Single-stranded DNA binding protein that interacts with the region upstream of the MYC gene. Binds specifically to the DNA sequence motif 5’-[AT]CT[AT][AT]T-3’. Probably has a role in DNA replication (406 aa) |
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0.455 | ||||||||||
 | SLC35E2B | solute carrier family 35, member E2B; Putative transporter (By similarity) (405 aa) |
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0.440 | ||||||||||
 | PHC2 | polyhomeotic homolog 2 (Drosophila) (858 aa) |
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0.424 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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