Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | ME2 | malic enzyme 2, NAD(+)-dependent, mitochondrial (584 aa) | ||||||||||||
Predicted Functional Partners:
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 | MDH1 | malate dehydrogenase 1, NAD (soluble) (352 aa) |
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0.983 | ||||||
 | PKM | pyruvate kinase, muscle (531 aa) |
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0.975 | ||||||||
 | LDHC | lactate dehydrogenase C; Possible role in sperm motility (332 aa) |
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0.971 | ||||||
 | LDHB | lactate dehydrogenase B (334 aa) |
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0.971 | ||||||
 | FH | fumarate hydratase; Also acts as a tumor suppressor (510 aa) |
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0.968 | ||||||
 | PC | pyruvate carboxylase; Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate (1178 aa) |
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0.966 | |||||||
 | MDH2 | malate dehydrogenase 2, NAD (mitochondrial) (338 aa) |
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0.962 | ||||||
 | LDHAL6B | lactate dehydrogenase A-like 6B (381 aa) |
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0.953 | ||||||
 | LDHAL6A | lactate dehydrogenase A-like 6A; Displays an lactate dehydrogenase activity. Significantly increases the transcriptional activity of JUN, when overexpressed (332 aa) |
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0.953 | ||||||
 | PDHA1 | pyruvate dehydrogenase (lipoamide) alpha 1 (428 aa) |
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0.925 | ||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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