node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGBL1 | SPOCK2 | ENSP00000413001 | ENSP00000321108 | ATP/GTP binding protein-like 1; Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5 (By similarity) | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2; May participate in diverse steps of neurogenesis. Binds calcium | 0.571 |
FST | SPARC | ENSP00000256759 | ENSP00000231061 | follistatin; Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH) | secreted protein, acidic, cysteine-rich (osteonectin); Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity | 0.477 |
FST | SPOCK2 | ENSP00000256759 | ENSP00000321108 | follistatin; Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH) | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2; May participate in diverse steps of neurogenesis. Binds calcium | 0.680 |
FST | SPOCK3 | ENSP00000256759 | ENSP00000349677 | follistatin; Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH) | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3 | 0.513 |
FST | TG | ENSP00000256759 | ENSP00000220616 | follistatin; Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH) | thyroglobulin | 0.457 |
MMP16 | PRG3 | ENSP00000286614 | ENSP00000287143 | matrix metallopeptidase 16 (membrane-inserted); Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells | proteoglycan 3; Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP. In vitro, stimulates neutrophil superoxide production and IL8 release, and histamine and leukotriene C4 release from basophils | 0.517 |
MMP16 | SPOCK2 | ENSP00000286614 | ENSP00000321108 | matrix metallopeptidase 16 (membrane-inserted); Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2; May participate in diverse steps of neurogenesis. Binds calcium | 0.749 |
MMP16 | SPOCK3 | ENSP00000286614 | ENSP00000349677 | matrix metallopeptidase 16 (membrane-inserted); Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3 | 0.751 |
PRG3 | MMP16 | ENSP00000287143 | ENSP00000286614 | proteoglycan 3; Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP. In vitro, stimulates neutrophil superoxide production and IL8 release, and histamine and leukotriene C4 release from basophils | matrix metallopeptidase 16 (membrane-inserted); Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells | 0.517 |
PRG3 | SPARC | ENSP00000287143 | ENSP00000231061 | proteoglycan 3; Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP. In vitro, stimulates neutrophil superoxide production and IL8 release, and histamine and leukotriene C4 release from basophils | secreted protein, acidic, cysteine-rich (osteonectin); Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity | 0.608 |
PRG3 | SPOCK2 | ENSP00000287143 | ENSP00000321108 | proteoglycan 3; Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP. In vitro, stimulates neutrophil superoxide production and IL8 release, and histamine and leukotriene C4 release from basophils | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2; May participate in diverse steps of neurogenesis. Binds calcium | 0.587 |
PRG3 | SPOCK3 | ENSP00000287143 | ENSP00000349677 | proteoglycan 3; Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP. In vitro, stimulates neutrophil superoxide production and IL8 release, and histamine and leukotriene C4 release from basophils | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3 | 0.815 |
SERINC5 | SPOCK2 | ENSP00000420863 | ENSP00000321108 | serine incorporator 5; Enhances the incorporation of serine into phosphatidylserine and sphingolipids. May play a role in providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes (By similarity) | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2; May participate in diverse steps of neurogenesis. Binds calcium | 0.636 |
SPARC | FST | ENSP00000231061 | ENSP00000256759 | secreted protein, acidic, cysteine-rich (osteonectin); Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity | follistatin; Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH) | 0.477 |
SPARC | PRG3 | ENSP00000231061 | ENSP00000287143 | secreted protein, acidic, cysteine-rich (osteonectin); Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity | proteoglycan 3; Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP. In vitro, stimulates neutrophil superoxide production and IL8 release, and histamine and leukotriene C4 release from basophils | 0.608 |
SPARC | SPOCK2 | ENSP00000231061 | ENSP00000321108 | secreted protein, acidic, cysteine-rich (osteonectin); Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2; May participate in diverse steps of neurogenesis. Binds calcium | 0.769 |
SPARC | SPOCK3 | ENSP00000231061 | ENSP00000349677 | secreted protein, acidic, cysteine-rich (osteonectin); Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3 | 0.760 |
SPARCL1 | SPOCK2 | ENSP00000282470 | ENSP00000321108 | SPARC-like 1 (hevin) | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2; May participate in diverse steps of neurogenesis. Binds calcium | 0.739 |
SPARCL1 | SPOCK3 | ENSP00000282470 | ENSP00000349677 | SPARC-like 1 (hevin) | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3 | 0.724 |
SPOCK2 | AGBL1 | ENSP00000321108 | ENSP00000413001 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2; May participate in diverse steps of neurogenesis. Binds calcium | ATP/GTP binding protein-like 1; Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5 (By similarity) | 0.571 |