EFHA2 protein (Homo sapiens) - STRING network view

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Score

EFHA2

EF-hand domain family, member A2; May play a role in mitochondrial calcium uptake (By similarity) (530 aa)

Predicted Functional Partners:

TNNI3

0.917

FGF20

0.889

FGF9

0.810

SGCZ

0.666

FGF16

0.610

CCDC90A

0.540

MTMR9

0.514

MCU

0.512

DGKH

0.506

ZCCHC8

0.485

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCDC90A	EFHA2	ENSP00000368468	ENSP00000321455	coiled-coil domain containing 90A; Key regulator of mitochondrial calcium uniporter (MCU) required for calcium entry into mitochondrion. Plays a direct role in uniporter-mediated calcium uptake, possibly via a direct interaction with MCU	EF-hand domain family, member A2; May play a role in mitochondrial calcium uptake (By similarity)	0.540
CCDC90A	MCU	ENSP00000368468	ENSP00000362144	coiled-coil domain containing 90A; Key regulator of mitochondrial calcium uniporter (MCU) required for calcium entry into mitochondrion. Plays a direct role in uniporter-mediated calcium uptake, possibly via a direct interaction with MCU	mitochondrial calcium uniporter; Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondrion. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes	0.648
DGKH	EFHA2	ENSP00000337572	ENSP00000321455	diacylglycerol kinase, eta	EF-hand domain family, member A2; May play a role in mitochondrial calcium uptake (By similarity)	0.506
EFHA2	CCDC90A	ENSP00000321455	ENSP00000368468	EF-hand domain family, member A2; May play a role in mitochondrial calcium uptake (By similarity)	coiled-coil domain containing 90A; Key regulator of mitochondrial calcium uniporter (MCU) required for calcium entry into mitochondrion. Plays a direct role in uniporter-mediated calcium uptake, possibly via a direct interaction with MCU	0.540
EFHA2	DGKH	ENSP00000321455	ENSP00000337572	EF-hand domain family, member A2; May play a role in mitochondrial calcium uptake (By similarity)	diacylglycerol kinase, eta	0.506
EFHA2	FGF16	ENSP00000321455	ENSP00000399324	EF-hand domain family, member A2; May play a role in mitochondrial calcium uptake (By similarity)	fibroblast growth factor 16	0.610
EFHA2	FGF20	ENSP00000321455	ENSP00000180166	EF-hand domain family, member A2; May play a role in mitochondrial calcium uptake (By similarity)	fibroblast growth factor 20; Neurotrophic factor that regulates central nervous development and function	0.889
EFHA2	FGF9	ENSP00000321455	ENSP00000371790	EF-hand domain family, member A2; May play a role in mitochondrial calcium uptake (By similarity)	fibroblast growth factor 9 (glia-activating factor); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors	0.810
EFHA2	MCU	ENSP00000321455	ENSP00000362144	EF-hand domain family, member A2; May play a role in mitochondrial calcium uptake (By similarity)	mitochondrial calcium uniporter; Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondrion. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes	0.512
EFHA2	MTMR9	ENSP00000321455	ENSP00000221086	EF-hand domain family, member A2; May play a role in mitochondrial calcium uptake (By similarity)	myotubularin related protein 9; Probable pseudophosphatase. Contains a Gly residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential)	0.514
EFHA2	SGCZ	ENSP00000321455	ENSP00000371512	EF-hand domain family, member A2; May play a role in mitochondrial calcium uptake (By similarity)	sarcoglycan, zeta; Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. May play a role in the maintenance of striated muscle membrane stability (By similarity)	0.666
EFHA2	TNNI3	ENSP00000321455	ENSP00000341838	EF-hand domain family, member A2; May play a role in mitochondrial calcium uptake (By similarity)	troponin I type 3 (cardiac); Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity	0.917
EFHA2	ZCCHC8	ENSP00000321455	ENSP00000337313	EF-hand domain family, member A2; May play a role in mitochondrial calcium uptake (By similarity)	zinc finger, CCHC domain containing 8; May be involved in pre-mRNA splicing	0.485
FGF16	EFHA2	ENSP00000399324	ENSP00000321455	fibroblast growth factor 16	EF-hand domain family, member A2; May play a role in mitochondrial calcium uptake (By similarity)	0.610
FGF20	EFHA2	ENSP00000180166	ENSP00000321455	fibroblast growth factor 20; Neurotrophic factor that regulates central nervous development and function	EF-hand domain family, member A2; May play a role in mitochondrial calcium uptake (By similarity)	0.889
FGF20	FGF9	ENSP00000180166	ENSP00000371790	fibroblast growth factor 20; Neurotrophic factor that regulates central nervous development and function	fibroblast growth factor 9 (glia-activating factor); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors	0.901
FGF9	EFHA2	ENSP00000371790	ENSP00000321455	fibroblast growth factor 9 (glia-activating factor); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors	EF-hand domain family, member A2; May play a role in mitochondrial calcium uptake (By similarity)	0.810
FGF9	FGF20	ENSP00000371790	ENSP00000180166	fibroblast growth factor 9 (glia-activating factor); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors	fibroblast growth factor 20; Neurotrophic factor that regulates central nervous development and function	0.901
MCU	CCDC90A	ENSP00000362144	ENSP00000368468	mitochondrial calcium uniporter; Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondrion. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes	coiled-coil domain containing 90A; Key regulator of mitochondrial calcium uniporter (MCU) required for calcium entry into mitochondrion. Plays a direct role in uniporter-mediated calcium uptake, possibly via a direct interaction with MCU	0.648
MCU	EFHA2	ENSP00000362144	ENSP00000321455	mitochondrial calcium uniporter; Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondrion. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes	EF-hand domain family, member A2; May play a role in mitochondrial calcium uptake (By similarity)	0.512

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