| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| G6PC | SLC37A3 | ENSP00000253801 | ENSP00000321498 | glucose-6-phosphatase, catalytic subunit; Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels | solute carrier family 37 (glycerol-3-phosphate transporter), member 3 | 0.472 |
| GDPD2 | SLC37A3 | ENSP00000414019 | ENSP00000321498 | glycerophosphodiester phosphodiesterase domain containing 2; Has glycerophosphoinositol inositolphosphodiesterase activity and specifically hydrolyzes glycerophosphoinositol, with no activity for other substrates such as glycerophosphoinositol 4- phosphate, glycerophosphocholine, glycerophosphoethanolamine, and glycerophosphoserine. Accelerates the program of osteoblast differentiation and growth. May play a role in remodeling of the actin cytoskeleton (By similarity) | solute carrier family 37 (glycerol-3-phosphate transporter), member 3 | 0.465 |
| JHDM1D | PPP1R11 | ENSP00000380692 | ENSP00000365963 | jumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae); Histone demethylase required for brain development. Specifically demethylates dimethylated ’Lys-9’ and ’Lys-27’ (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 ’Lys-20’ residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated ’Lys-4’ of histone H3 (H3K4me3), affecting histone demethylase specificity- in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 [...] | protein phosphatase 1, regulatory (inhibitor) subunit 11 | 0.511 |
| JHDM1D | SLC37A3 | ENSP00000380692 | ENSP00000321498 | jumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae); Histone demethylase required for brain development. Specifically demethylates dimethylated ’Lys-9’ and ’Lys-27’ (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 ’Lys-20’ residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated ’Lys-4’ of histone H3 (H3K4me3), affecting histone demethylase specificity- in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 [...] | solute carrier family 37 (glycerol-3-phosphate transporter), member 3 | 0.738 |
| JHDM1D | SLC5A7 | ENSP00000380692 | ENSP00000264047 | jumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae); Histone demethylase required for brain development. Specifically demethylates dimethylated ’Lys-9’ and ’Lys-27’ (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 ’Lys-20’ residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated ’Lys-4’ of histone H3 (H3K4me3), affecting histone demethylase specificity- in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 [...] | solute carrier family 5 (choline transporter), member 7; Imports choline from the extracellular space to the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion- and chloride ion- dependent | 0.614 |
| JHDM1D | ST6GAL2 | ENSP00000380692 | ENSP00000355273 | jumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae); Histone demethylase required for brain development. Specifically demethylates dimethylated ’Lys-9’ and ’Lys-27’ (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 ’Lys-20’ residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated ’Lys-4’ of histone H3 (H3K4me3), affecting histone demethylase specificity- in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 [...] | ST6 beta-galactosamide alpha-2,6-sialyltranferase 2; Transfers sialic acid from the donor of substrate CMP- sialic acid to galactose containing acceptor substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids | 0.614 |
| KHDC3L | SLC37A3 | ENSP00000359392 | ENSP00000321498 | KH domain containing 3-like, subcortical maternal complex member | solute carrier family 37 (glycerol-3-phosphate transporter), member 3 | 0.469 |
| PPP1R11 | JHDM1D | ENSP00000365963 | ENSP00000380692 | protein phosphatase 1, regulatory (inhibitor) subunit 11 | jumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae); Histone demethylase required for brain development. Specifically demethylates dimethylated ’Lys-9’ and ’Lys-27’ (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 ’Lys-20’ residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated ’Lys-4’ of histone H3 (H3K4me3), affecting histone demethylase specificity- in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 [...] | 0.511 |
| PPP1R11 | SLC37A3 | ENSP00000365963 | ENSP00000321498 | protein phosphatase 1, regulatory (inhibitor) subunit 11 | solute carrier family 37 (glycerol-3-phosphate transporter), member 3 | 0.506 |
| RAB19 | SLC37A3 | ENSP00000348778 | ENSP00000321498 | RAB19, member RAS oncogene family | solute carrier family 37 (glycerol-3-phosphate transporter), member 3 | 0.548 |
| ROPN1L | SLC37A3 | ENSP00000274134 | ENSP00000321498 | rhophilin associated tail protein 1-like | solute carrier family 37 (glycerol-3-phosphate transporter), member 3 | 0.691 |
| SLC17A5 | SLC37A3 | ENSP00000348019 | ENSP00000321498 | solute carrier family 17 (anion/sugar transporter), member 5; Transports glucuronic acid and free sialic acid out of the lysosome after it is cleaved from sialoglycoconjugates undergoing degradation, this is required for normal CNS myelination. Mediates aspartate and glutamate membrane potential- dependent uptake into synaptic vesicles and synaptic-like microvesicles. Also functions as an electrogenic 2NO(3)(-)/H(+) cotransporter in the plasma membrane of salivary gland acinar cells, mediating the physiological nitrate efflux, 25% of the circulating nitrate ions is typically removed an [...] | solute carrier family 37 (glycerol-3-phosphate transporter), member 3 | 0.555 |
| SLC37A3 | G6PC | ENSP00000321498 | ENSP00000253801 | solute carrier family 37 (glycerol-3-phosphate transporter), member 3 | glucose-6-phosphatase, catalytic subunit; Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels | 0.472 |
| SLC37A3 | GDPD2 | ENSP00000321498 | ENSP00000414019 | solute carrier family 37 (glycerol-3-phosphate transporter), member 3 | glycerophosphodiester phosphodiesterase domain containing 2; Has glycerophosphoinositol inositolphosphodiesterase activity and specifically hydrolyzes glycerophosphoinositol, with no activity for other substrates such as glycerophosphoinositol 4- phosphate, glycerophosphocholine, glycerophosphoethanolamine, and glycerophosphoserine. Accelerates the program of osteoblast differentiation and growth. May play a role in remodeling of the actin cytoskeleton (By similarity) | 0.465 |
| SLC37A3 | JHDM1D | ENSP00000321498 | ENSP00000380692 | solute carrier family 37 (glycerol-3-phosphate transporter), member 3 | jumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae); Histone demethylase required for brain development. Specifically demethylates dimethylated ’Lys-9’ and ’Lys-27’ (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 ’Lys-20’ residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated ’Lys-4’ of histone H3 (H3K4me3), affecting histone demethylase specificity- in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 [...] | 0.738 |
| SLC37A3 | KHDC3L | ENSP00000321498 | ENSP00000359392 | solute carrier family 37 (glycerol-3-phosphate transporter), member 3 | KH domain containing 3-like, subcortical maternal complex member | 0.469 |
| SLC37A3 | PPP1R11 | ENSP00000321498 | ENSP00000365963 | solute carrier family 37 (glycerol-3-phosphate transporter), member 3 | protein phosphatase 1, regulatory (inhibitor) subunit 11 | 0.506 |
| SLC37A3 | RAB19 | ENSP00000321498 | ENSP00000348778 | solute carrier family 37 (glycerol-3-phosphate transporter), member 3 | RAB19, member RAS oncogene family | 0.548 |
| SLC37A3 | ROPN1L | ENSP00000321498 | ENSP00000274134 | solute carrier family 37 (glycerol-3-phosphate transporter), member 3 | rhophilin associated tail protein 1-like | 0.691 |
| SLC37A3 | SLC17A5 | ENSP00000321498 | ENSP00000348019 | solute carrier family 37 (glycerol-3-phosphate transporter), member 3 | solute carrier family 17 (anion/sugar transporter), member 5; Transports glucuronic acid and free sialic acid out of the lysosome after it is cleaved from sialoglycoconjugates undergoing degradation, this is required for normal CNS myelination. Mediates aspartate and glutamate membrane potential- dependent uptake into synaptic vesicles and synaptic-like microvesicles. Also functions as an electrogenic 2NO(3)(-)/H(+) cotransporter in the plasma membrane of salivary gland acinar cells, mediating the physiological nitrate efflux, 25% of the circulating nitrate ions is typically removed an [...] | 0.555 |
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