node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AMD1 | AZIN1 | ENSP00000357880 | ENSP00000321507 | adenosylmethionine decarboxylase 1 | antizyme inhibitor 1; Regulates cellular polyamine homeostasis (By similarity). Inhibits antizyme-dependent ornithine decarboxylase degradation by binding to antizyme | 0.831 |
AMD1 | ODC1 | ENSP00000357880 | ENSP00000234111 | adenosylmethionine decarboxylase 1 | ornithine decarboxylase 1 | 0.946 |
AMD1 | SMS | ENSP00000357880 | ENSP00000385746 | adenosylmethionine decarboxylase 1 | spermine synthase; Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM) | 0.980 |
AMD1 | SRM | ENSP00000357880 | ENSP00000366156 | adenosylmethionine decarboxylase 1 | spermidine synthase; Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has a strong preference for putrescine as substrate, and has very low activity towards 1,3-diaminopropane. Has extremely low activity towards spermidine | 0.987 |
AMD1 | UBC | ENSP00000357880 | ENSP00000344818 | adenosylmethionine decarboxylase 1 | ubiquitin C | 0.626 |
AZIN1 | AMD1 | ENSP00000321507 | ENSP00000357880 | antizyme inhibitor 1; Regulates cellular polyamine homeostasis (By similarity). Inhibits antizyme-dependent ornithine decarboxylase degradation by binding to antizyme | adenosylmethionine decarboxylase 1 | 0.831 |
AZIN1 | FGF2 | ENSP00000321507 | ENSP00000264498 | antizyme inhibitor 1; Regulates cellular polyamine homeostasis (By similarity). Inhibits antizyme-dependent ornithine decarboxylase degradation by binding to antizyme | fibroblast growth factor 2 (basic) | 0.800 |
AZIN1 | OAZ1 | ENSP00000321507 | ENSP00000464146 | antizyme inhibitor 1; Regulates cellular polyamine homeostasis (By similarity). Inhibits antizyme-dependent ornithine decarboxylase degradation by binding to antizyme | ornithine decarboxylase antizyme 1; Binds to, and destabilizes, ornithine decarboxylase which is then degraded. Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1 | 0.987 |
AZIN1 | OAZ2 | ENSP00000321507 | ENSP00000463013 | antizyme inhibitor 1; Regulates cellular polyamine homeostasis (By similarity). Inhibits antizyme-dependent ornithine decarboxylase degradation by binding to antizyme | ornithine decarboxylase antizyme 2; Binds to, and destabilizes, ornithine decarboxylase. Does not accelerate ornithine decarboxylase degeneration (By similarity) | 0.993 |
AZIN1 | OAZ3 | ENSP00000321507 | ENSP00000415904 | antizyme inhibitor 1; Regulates cellular polyamine homeostasis (By similarity). Inhibits antizyme-dependent ornithine decarboxylase degradation by binding to antizyme | ornithine decarboxylase antizyme 3; Binds to, and destabilizes, ornithine decarboxylase. Does not accelerate ornithine decarboxylase degeneration. OAZ3 probably plays a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells | 0.994 |
AZIN1 | ODC1 | ENSP00000321507 | ENSP00000234111 | antizyme inhibitor 1; Regulates cellular polyamine homeostasis (By similarity). Inhibits antizyme-dependent ornithine decarboxylase degradation by binding to antizyme | ornithine decarboxylase 1 | 0.903 |
AZIN1 | SMS | ENSP00000321507 | ENSP00000385746 | antizyme inhibitor 1; Regulates cellular polyamine homeostasis (By similarity). Inhibits antizyme-dependent ornithine decarboxylase degradation by binding to antizyme | spermine synthase; Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM) | 0.767 |
AZIN1 | SRM | ENSP00000321507 | ENSP00000366156 | antizyme inhibitor 1; Regulates cellular polyamine homeostasis (By similarity). Inhibits antizyme-dependent ornithine decarboxylase degradation by binding to antizyme | spermidine synthase; Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has a strong preference for putrescine as substrate, and has very low activity towards 1,3-diaminopropane. Has extremely low activity towards spermidine | 0.791 |
AZIN1 | THNSL1 | ENSP00000321507 | ENSP00000365534 | antizyme inhibitor 1; Regulates cellular polyamine homeostasis (By similarity). Inhibits antizyme-dependent ornithine decarboxylase degradation by binding to antizyme | threonine synthase-like 1 (S. cerevisiae) | 0.777 |
AZIN1 | UBC | ENSP00000321507 | ENSP00000344818 | antizyme inhibitor 1; Regulates cellular polyamine homeostasis (By similarity). Inhibits antizyme-dependent ornithine decarboxylase degradation by binding to antizyme | ubiquitin C | 0.907 |
FGF2 | AZIN1 | ENSP00000264498 | ENSP00000321507 | fibroblast growth factor 2 (basic) | antizyme inhibitor 1; Regulates cellular polyamine homeostasis (By similarity). Inhibits antizyme-dependent ornithine decarboxylase degradation by binding to antizyme | 0.800 |
FGF2 | UBC | ENSP00000264498 | ENSP00000344818 | fibroblast growth factor 2 (basic) | ubiquitin C | 0.423 |
OAZ1 | AZIN1 | ENSP00000464146 | ENSP00000321507 | ornithine decarboxylase antizyme 1; Binds to, and destabilizes, ornithine decarboxylase which is then degraded. Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1 | antizyme inhibitor 1; Regulates cellular polyamine homeostasis (By similarity). Inhibits antizyme-dependent ornithine decarboxylase degradation by binding to antizyme | 0.987 |
OAZ1 | OAZ2 | ENSP00000464146 | ENSP00000463013 | ornithine decarboxylase antizyme 1; Binds to, and destabilizes, ornithine decarboxylase which is then degraded. Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1 | ornithine decarboxylase antizyme 2; Binds to, and destabilizes, ornithine decarboxylase. Does not accelerate ornithine decarboxylase degeneration (By similarity) | 0.958 |
OAZ1 | OAZ3 | ENSP00000464146 | ENSP00000415904 | ornithine decarboxylase antizyme 1; Binds to, and destabilizes, ornithine decarboxylase which is then degraded. Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1 | ornithine decarboxylase antizyme 3; Binds to, and destabilizes, ornithine decarboxylase. Does not accelerate ornithine decarboxylase degeneration. OAZ3 probably plays a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells | 0.983 |