Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
CCDC74B CCDC74B CRKL CRKL LRRC43 LRRC43 DCBLD2 DCBLD2 FYN FYN EGFR EGFR CEP68 CEP68 UBC UBC TRAF6 TRAF6 SEMA4B SEMA4B
"DCBLD2" - discoidin, CUB and LCCL domain containing 2 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DCBLD2discoidin, CUB and LCCL domain containing 2 (775 aa)    
Predicted Functional Partners:
UBC
ubiquitin C (685 aa)
        score_image       0.795
SEMA4B
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B; Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons (By similarity) (837 aa)
        score_image   score_image   0.609
CRKL
v-crk sarcoma virus CT10 oncogene homolog (avian)-like; May mediate the transduction of intracellular signals (303 aa)
        score_image   score_image   0.587
CEP68
centrosomal protein 68kDa (757 aa)
            score_image   0.583
FYN
FYN oncogene related to SRC, FGR, YES; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motilit [...] (537 aa)
        score_image       0.576
TRAF6
TNF receptor-associated factor 6, E3 ubiquitin protein ligase; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of ’Lys-63’-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF- kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Ad [...] (522 aa)
        score_image       0.576
EGFR
epidermal growth factor receptor (1210 aa)
        score_image       0.576
LRRC43
leucine rich repeat containing 43 (656 aa)
            score_image   0.568
CCDC74B
coiled-coil domain containing 74B (380 aa)
            score_image   0.472
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: low (35%)