node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DNAJB13 | SEPT4 | ENSP00000344431 | ENSP00000321674 | DnaJ (Hsp40) homolog, subfamily B, member 13; May be involved in inhibiting testis spermatogenesis apoptosis | septin 4; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion. Isoform ARTS, but not the other isoforms, is required for the induction of cell death mediated by TGF-beta and by other apoptotic stimuli | 0.944 |
DYRK1A | SEPT4 | ENSP00000381932 | ENSP00000321674 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A; May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates such as CRY2, FOXO1 and SIRT1 | septin 4; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion. Isoform ARTS, but not the other isoforms, is required for the induction of cell death mediated by TGF-beta and by other apoptotic stimuli | 0.804 |
DYRK1A | SNCA | ENSP00000381932 | ENSP00000338345 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A; May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates such as CRY2, FOXO1 and SIRT1 | synuclein, alpha (non A4 component of amyloid precursor); May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation | 0.925 |
DYRK1A | UBC | ENSP00000381932 | ENSP00000344818 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A; May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates such as CRY2, FOXO1 and SIRT1 | ubiquitin C | 0.569 |
KRT16 | PVRL2 | ENSP00000301653 | ENSP00000252483 | keratin 16 | poliovirus receptor-related 2 (herpesvirus entry mediator B); Probable cell adhesion protein | 0.800 |
KRT16 | SEPP1 | ENSP00000301653 | ENSP00000420939 | keratin 16 | selenoprotein P, plasma, 1; Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium. May supply selenium to tissues such as brain and testis | 0.818 |
KRT16 | SEPT4 | ENSP00000301653 | ENSP00000321674 | keratin 16 | septin 4; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion. Isoform ARTS, but not the other isoforms, is required for the induction of cell death mediated by TGF-beta and by other apoptotic stimuli | 0.808 |
KRT16 | UBC | ENSP00000301653 | ENSP00000344818 | keratin 16 | ubiquitin C | 0.837 |
PVRL2 | KRT16 | ENSP00000252483 | ENSP00000301653 | poliovirus receptor-related 2 (herpesvirus entry mediator B); Probable cell adhesion protein | keratin 16 | 0.800 |
PVRL2 | SEPP1 | ENSP00000252483 | ENSP00000420939 | poliovirus receptor-related 2 (herpesvirus entry mediator B); Probable cell adhesion protein | selenoprotein P, plasma, 1; Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium. May supply selenium to tissues such as brain and testis | 0.802 |
PVRL2 | SEPT4 | ENSP00000252483 | ENSP00000321674 | poliovirus receptor-related 2 (herpesvirus entry mediator B); Probable cell adhesion protein | septin 4; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion. Isoform ARTS, but not the other isoforms, is required for the induction of cell death mediated by TGF-beta and by other apoptotic stimuli | 0.801 |
PVRL2 | UBC | ENSP00000252483 | ENSP00000344818 | poliovirus receptor-related 2 (herpesvirus entry mediator B); Probable cell adhesion protein | ubiquitin C | 0.483 |
SEPP1 | KRT16 | ENSP00000420939 | ENSP00000301653 | selenoprotein P, plasma, 1; Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium. May supply selenium to tissues such as brain and testis | keratin 16 | 0.818 |
SEPP1 | PVRL2 | ENSP00000420939 | ENSP00000252483 | selenoprotein P, plasma, 1; Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium. May supply selenium to tissues such as brain and testis | poliovirus receptor-related 2 (herpesvirus entry mediator B); Probable cell adhesion protein | 0.802 |
SEPP1 | SEPT4 | ENSP00000420939 | ENSP00000321674 | selenoprotein P, plasma, 1; Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium. May supply selenium to tissues such as brain and testis | septin 4; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion. Isoform ARTS, but not the other isoforms, is required for the induction of cell death mediated by TGF-beta and by other apoptotic stimuli | 0.802 |
SEPT14 | SEPT4 | ENSP00000373627 | ENSP00000321674 | septin 14; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential) | septin 4; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion. Isoform ARTS, but not the other isoforms, is required for the induction of cell death mediated by TGF-beta and by other apoptotic stimuli | 0.916 |
SEPT4 | DNAJB13 | ENSP00000321674 | ENSP00000344431 | septin 4; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion. Isoform ARTS, but not the other isoforms, is required for the induction of cell death mediated by TGF-beta and by other apoptotic stimuli | DnaJ (Hsp40) homolog, subfamily B, member 13; May be involved in inhibiting testis spermatogenesis apoptosis | 0.944 |
SEPT4 | DYRK1A | ENSP00000321674 | ENSP00000381932 | septin 4; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion. Isoform ARTS, but not the other isoforms, is required for the induction of cell death mediated by TGF-beta and by other apoptotic stimuli | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A; May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates such as CRY2, FOXO1 and SIRT1 | 0.804 |
SEPT4 | KRT16 | ENSP00000321674 | ENSP00000301653 | septin 4; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion. Isoform ARTS, but not the other isoforms, is required for the induction of cell death mediated by TGF-beta and by other apoptotic stimuli | keratin 16 | 0.808 |
SEPT4 | PVRL2 | ENSP00000321674 | ENSP00000252483 | septin 4; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion. Isoform ARTS, but not the other isoforms, is required for the induction of cell death mediated by TGF-beta and by other apoptotic stimuli | poliovirus receptor-related 2 (herpesvirus entry mediator B); Probable cell adhesion protein | 0.801 |