| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| GDF9 | INSL3 | ENSP00000296875 | ENSP00000321724 | growth differentiation factor 9; Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells | insulin-like 3 (Leydig cell); Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor | 0.842 |
| IDE | INSL3 | ENSP00000265986 | ENSP00000321724 | insulin-degrading enzyme; Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia | insulin-like 3 (Leydig cell); Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor | 0.817 |
| INSL3 | GDF9 | ENSP00000321724 | ENSP00000296875 | insulin-like 3 (Leydig cell); Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor | growth differentiation factor 9; Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells | 0.842 |
| INSL3 | IDE | ENSP00000321724 | ENSP00000265986 | insulin-like 3 (Leydig cell); Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor | insulin-degrading enzyme; Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia | 0.817 |
| INSL3 | INSL4 | ENSP00000321724 | ENSP00000239316 | insulin-like 3 (Leydig cell); Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor | insulin-like 4 (placenta); May play an important role in trophoblast development and in the regulation of bone formation | 0.750 |
| INSL3 | LEP | ENSP00000321724 | ENSP00000312652 | insulin-like 3 (Leydig cell); Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor | leptin; May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass | 0.827 |
| INSL3 | NR4A1 | ENSP00000321724 | ENSP00000353427 | insulin-like 3 (Leydig cell); Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor | nuclear receptor subfamily 4, group A, member 1; Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5’- AAAAGGTCA-3’ (By similarity). May inhibit NF-kappa-B transactivation of IL2 | 0.854 |
| INSL3 | RLN1 | ENSP00000321724 | ENSP00000223862 | insulin-like 3 (Leydig cell); Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor | relaxin 1; Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix | 0.758 |
| INSL3 | RLN3 | ENSP00000321724 | ENSP00000397415 | insulin-like 3 (Leydig cell); Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor | relaxin 3; May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 (GPCR135) and relaxin-3 receptor-2 (GPCR142) | 0.727 |
| INSL3 | RXFP1 | ENSP00000321724 | ENSP00000303248 | insulin-like 3 (Leydig cell); Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor | relaxin/insulin-like family peptide receptor 1; Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP | 0.961 |
| INSL3 | RXFP2 | ENSP00000321724 | ENSP00000298386 | insulin-like 3 (Leydig cell); Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor | relaxin/insulin-like family peptide receptor 2; Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3) | 0.995 |
| INSL3 | RXFP4 | ENSP00000321724 | ENSP00000357301 | insulin-like 3 (Leydig cell); Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor | relaxin/insulin-like family peptide receptor 4; High affinity receptor for INSL5. Also acts as receptor for RLN3/relaxin-3, as well as bradykinin and kallidin. Binding of the ligand inhibit cAMP accumulation | 0.708 |
| INSL4 | INSL3 | ENSP00000239316 | ENSP00000321724 | insulin-like 4 (placenta); May play an important role in trophoblast development and in the regulation of bone formation | insulin-like 3 (Leydig cell); Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor | 0.750 |
| INSL4 | RLN1 | ENSP00000239316 | ENSP00000223862 | insulin-like 4 (placenta); May play an important role in trophoblast development and in the regulation of bone formation | relaxin 1; Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix | 0.752 |
| INSL4 | RLN3 | ENSP00000239316 | ENSP00000397415 | insulin-like 4 (placenta); May play an important role in trophoblast development and in the regulation of bone formation | relaxin 3; May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 (GPCR135) and relaxin-3 receptor-2 (GPCR142) | 0.700 |
| INSL4 | RXFP1 | ENSP00000239316 | ENSP00000303248 | insulin-like 4 (placenta); May play an important role in trophoblast development and in the regulation of bone formation | relaxin/insulin-like family peptide receptor 1; Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP | 0.585 |
| INSL4 | RXFP2 | ENSP00000239316 | ENSP00000298386 | insulin-like 4 (placenta); May play an important role in trophoblast development and in the regulation of bone formation | relaxin/insulin-like family peptide receptor 2; Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3) | 0.580 |
| INSL4 | RXFP4 | ENSP00000239316 | ENSP00000357301 | insulin-like 4 (placenta); May play an important role in trophoblast development and in the regulation of bone formation | relaxin/insulin-like family peptide receptor 4; High affinity receptor for INSL5. Also acts as receptor for RLN3/relaxin-3, as well as bradykinin and kallidin. Binding of the ligand inhibit cAMP accumulation | 0.585 |
| LEP | INSL3 | ENSP00000312652 | ENSP00000321724 | leptin; May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass | insulin-like 3 (Leydig cell); Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor | 0.827 |
| NR4A1 | INSL3 | ENSP00000353427 | ENSP00000321724 | nuclear receptor subfamily 4, group A, member 1; Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5’- AAAAGGTCA-3’ (By similarity). May inhibit NF-kappa-B transactivation of IL2 | insulin-like 3 (Leydig cell); Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor | 0.854 |
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