node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BRAF | NGF | ENSP00000288602 | ENSP00000358525 | v-raf murine sarcoma viral oncogene homolog B1 | nerve growth factor (beta polypeptide); Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival | 0.900 |
BRAF | NTRK1 | ENSP00000288602 | ENSP00000431418 | v-raf murine sarcoma viral oncogene homolog B1 | neurotrophic tyrosine kinase, receptor, type 1 | 0.905 |
BRAF | RIT1 | ENSP00000288602 | ENSP00000357306 | v-raf murine sarcoma viral oncogene homolog B1 | Ras-like without CAAX 1; Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF- dependent neuronal differentiation | 0.924 |
BRAF | RIT2 | ENSP00000288602 | ENSP00000321805 | v-raf murine sarcoma viral oncogene homolog B1 | Ras-like without CAAX 2; Binds and exchanges GTP and GDP (By similarity) | 0.924 |
BRAF | SOS1 | ENSP00000288602 | ENSP00000384675 | v-raf murine sarcoma viral oncogene homolog B1 | son of sevenless homolog 1 (Drosophila); Promotes the exchange of Ras-bound GDP by GTP. Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity) | 0.714 |
FTH1 | RIT2 | ENSP00000273550 | ENSP00000321805 | ferritin, heavy polypeptide 1; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity) | Ras-like without CAAX 2; Binds and exchanges GTP and GDP (By similarity) | 0.768 |
ITM2C | RIT2 | ENSP00000322730 | ENSP00000321805 | integral membrane protein 2C | Ras-like without CAAX 2; Binds and exchanges GTP and GDP (By similarity) | 0.796 |
MAP3K19 | RIT1 | ENSP00000365005 | ENSP00000357306 | mitogen-activated protein kinase kinase kinase 19 | Ras-like without CAAX 1; Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF- dependent neuronal differentiation | 0.709 |
MAP3K19 | RIT2 | ENSP00000365005 | ENSP00000321805 | mitogen-activated protein kinase kinase kinase 19 | Ras-like without CAAX 2; Binds and exchanges GTP and GDP (By similarity) | 0.709 |
MAP3K19 | SOS1 | ENSP00000365005 | ENSP00000384675 | mitogen-activated protein kinase kinase kinase 19 | son of sevenless homolog 1 (Drosophila); Promotes the exchange of Ras-bound GDP by GTP. Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity) | 0.500 |
NGF | BRAF | ENSP00000358525 | ENSP00000288602 | nerve growth factor (beta polypeptide); Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival | v-raf murine sarcoma viral oncogene homolog B1 | 0.900 |
NGF | NTRK1 | ENSP00000358525 | ENSP00000431418 | nerve growth factor (beta polypeptide); Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival | neurotrophic tyrosine kinase, receptor, type 1 | 0.999 |
NGF | RIT1 | ENSP00000358525 | ENSP00000357306 | nerve growth factor (beta polypeptide); Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival | Ras-like without CAAX 1; Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF- dependent neuronal differentiation | 0.932 |
NGF | RIT2 | ENSP00000358525 | ENSP00000321805 | nerve growth factor (beta polypeptide); Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival | Ras-like without CAAX 2; Binds and exchanges GTP and GDP (By similarity) | 0.901 |
NGF | SOS1 | ENSP00000358525 | ENSP00000384675 | nerve growth factor (beta polypeptide); Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival | son of sevenless homolog 1 (Drosophila); Promotes the exchange of Ras-bound GDP by GTP. Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity) | 0.905 |
NTRK1 | BRAF | ENSP00000431418 | ENSP00000288602 | neurotrophic tyrosine kinase, receptor, type 1 | v-raf murine sarcoma viral oncogene homolog B1 | 0.905 |
NTRK1 | NGF | ENSP00000431418 | ENSP00000358525 | neurotrophic tyrosine kinase, receptor, type 1 | nerve growth factor (beta polypeptide); Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival | 0.999 |
NTRK1 | POU4F1 | ENSP00000431418 | ENSP00000366413 | neurotrophic tyrosine kinase, receptor, type 1 | POU class 4 homeobox 1; Probable transcription factor which may play a role in the regulation of specific gene expression within a subset of neuronal lineages. May play a role in determining or maintaining the identities of a small subset of visual system neurons | 0.891 |
NTRK1 | RIT1 | ENSP00000431418 | ENSP00000357306 | neurotrophic tyrosine kinase, receptor, type 1 | Ras-like without CAAX 1; Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF- dependent neuronal differentiation | 0.903 |
NTRK1 | RIT2 | ENSP00000431418 | ENSP00000321805 | neurotrophic tyrosine kinase, receptor, type 1 | Ras-like without CAAX 2; Binds and exchanges GTP and GDP (By similarity) | 0.900 |