| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANKRD49 | TRIT1 | ENSP00000303518 | ENSP00000321810 | ankyrin repeat domain 49 | tRNA isopentenyltransferase 1; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) | 0.725 |
| CDK5RAP1 | TRIT1 | ENSP00000217372 | ENSP00000321810 | CDK5 regulatory subunit associated protein 1 | tRNA isopentenyltransferase 1; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) | 0.657 |
| CDK5RAP1 | TRMT1 | ENSP00000217372 | ENSP00000350352 | CDK5 regulatory subunit associated protein 1 | tRNA methyltransferase 1 homolog (S. cerevisiae); Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups | 0.400 |
| CDK5RAP1 | TRMT1L | ENSP00000217372 | ENSP00000356476 | CDK5 regulatory subunit associated protein 1 | tRNA methyltransferase 1 homolog (S. cerevisiae)-like; May play a role in motor coordination and exploratory behavior (By similarity) | 0.400 |
| CRIPT | TRIT1 | ENSP00000238892 | ENSP00000321810 | cysteine-rich PDZ-binding protein; Involved in the cytoskeletal anchoring of DLG4 in excitatory synapses (By similarity) | tRNA isopentenyltransferase 1; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) | 0.663 |
| GTPBP6 | MLH1 | ENSP00000316598 | ENSP00000231790 | GTP binding protein 6 (putative) | mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli); Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS- heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to deg [...] | 0.403 |
| GTPBP6 | MLH3 | ENSP00000316598 | ENSP00000348020 | GTP binding protein 6 (putative) | mutL homolog 3 (E. coli); Probably involved in the repair of mismatches in DNA | 0.403 |
| GTPBP6 | PMS1 | ENSP00000316598 | ENSP00000406490 | GTP binding protein 6 (putative) | PMS1 postmeiotic segregation increased 1 (S. cerevisiae); Probably involved in the repair of mismatches in DNA | 0.403 |
| GTPBP6 | PMS2 | ENSP00000316598 | ENSP00000265849 | GTP binding protein 6 (putative) | PMS2 postmeiotic segregation increased 2 (S. cerevisiae); Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2- MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade [...] | 0.403 |
| GTPBP6 | TRIT1 | ENSP00000316598 | ENSP00000321810 | GTP binding protein 6 (putative) | tRNA isopentenyltransferase 1; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) | 0.671 |
| MLH1 | GTPBP6 | ENSP00000231790 | ENSP00000316598 | mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli); Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS- heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to deg [...] | GTP binding protein 6 (putative) | 0.403 |
| MLH1 | MLH3 | ENSP00000231790 | ENSP00000348020 | mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli); Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS- heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to deg [...] | mutL homolog 3 (E. coli); Probably involved in the repair of mismatches in DNA | 0.999 |
| MLH1 | PMS1 | ENSP00000231790 | ENSP00000406490 | mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli); Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS- heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to deg [...] | PMS1 postmeiotic segregation increased 1 (S. cerevisiae); Probably involved in the repair of mismatches in DNA | 0.995 |
| MLH1 | PMS2 | ENSP00000231790 | ENSP00000265849 | mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli); Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS- heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to deg [...] | PMS2 postmeiotic segregation increased 2 (S. cerevisiae); Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2- MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade [...] | 0.999 |
| MLH1 | TRIT1 | ENSP00000231790 | ENSP00000321810 | mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli); Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS- heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to deg [...] | tRNA isopentenyltransferase 1; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) | 0.861 |
| MLH3 | GTPBP6 | ENSP00000348020 | ENSP00000316598 | mutL homolog 3 (E. coli); Probably involved in the repair of mismatches in DNA | GTP binding protein 6 (putative) | 0.403 |
| MLH3 | MLH1 | ENSP00000348020 | ENSP00000231790 | mutL homolog 3 (E. coli); Probably involved in the repair of mismatches in DNA | mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli); Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS- heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to deg [...] | 0.999 |
| MLH3 | PMS1 | ENSP00000348020 | ENSP00000406490 | mutL homolog 3 (E. coli); Probably involved in the repair of mismatches in DNA | PMS1 postmeiotic segregation increased 1 (S. cerevisiae); Probably involved in the repair of mismatches in DNA | 0.826 |
| MLH3 | PMS2 | ENSP00000348020 | ENSP00000265849 | mutL homolog 3 (E. coli); Probably involved in the repair of mismatches in DNA | PMS2 postmeiotic segregation increased 2 (S. cerevisiae); Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2- MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade [...] | 0.914 |
| MLH3 | TRIT1 | ENSP00000348020 | ENSP00000321810 | mutL homolog 3 (E. coli); Probably involved in the repair of mismatches in DNA | tRNA isopentenyltransferase 1; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) | 0.859 |
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