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ZNF781 ZNF781 MSMO1 MSMO1 AGMO AGMO CH25H CH25H CYP4F12 CYP4F12 LSS LSS FDFT1 FDFT1 POR POR SC5DL SC5DL C5orf4 C5orf4 DECR1 DECR1
"CYP4F12" - cytochrome P450, family 4, subfamily F, polypeptide 12 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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CYP4F12cytochrome P450, family 4, subfamily F, polypeptide 12; Catalyzes leukotriene B4 omega-hydroxylation and arachidonic acid omega-hydroxylation but with an activity much lower than that of CYP4F2. Catalyzes the hydroxylation of the antihistamine ebastine (524 aa)    
Predicted Functional Partners:
AGMO
alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes (445 aa)
       score_image score_image   score_image   0.752
SC5DL
sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like; Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol (299 aa)
       score_image score_image   score_image   0.752
ZNF781
zinc finger protein 781; May be involved in transcriptional regulation (327 aa)
             score_image   0.590
POR
P450 (cytochrome) oxidoreductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5 (680 aa)
   score_image         score_image   0.582
LSS
lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase); Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus (732 aa)
         score_image   score_image   0.574
CH25H
cholesterol 25-hydroxylase; Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25- hydroxycholesterol by macrophages may play a role in Leydig cell differentiation (272 aa)
       score_image score_image   score_image   0.573
C5orf4
chromosome 5 open reading frame 4 (333 aa)
       score_image score_image   score_image   0.573
MSMO1
methylsterol monooxygenase 1 (293 aa)
       score_image score_image   score_image   0.573
DECR1
2,4-dienoyl CoA reductase 1, mitochondrial; Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3- enoyl-CoA (335 aa)
             score_image   0.536
FDFT1
farnesyl-diphosphate farnesyltransferase 1 (417 aa)
 score_image       score_image   score_image   0.535
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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