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STRINGSTRING
MX1 MX1 DSCR3 DSCR3 NKX2-6 NKX2-6 PSMG1 PSMG1 DSCR4 DSCR4 TBX5 TBX5 CRELD1 CRELD1 RBM19 RBM19 RTN3 RTN3 PREPL PREPL CA2 CA2
"CRELD1" - cysteine-rich with EGF-like domains 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
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Textmining
[Homology]
Score
CRELD1cysteine-rich with EGF-like domains 1 (422 aa)    
Predicted Functional Partners:
RTN3
reticulon 3 (1013 aa)
            score_image   0.821
NKX2-6
NK2 homeobox 6; In conjunction with NKX2-5, may play a role in both pharyngeal and cardiac embryonic development (By similarity) (301 aa)
            score_image   0.725
DSCR3
Down syndrome critical region gene 3 (297 aa)
            score_image   0.609
DSCR4
Down syndrome critical region gene 4 (127 aa)
            score_image   0.607
RBM19
RNA binding motif protein 19; Plays a role in embryo pre-implantation development (By similarity) (960 aa)
            score_image   0.607
PREPL
prolyl endopeptidase-like (727 aa)
            score_image   0.567
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) (662 aa)
            score_image   0.563
TBX5
T-box 5; Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation (518 aa)
            score_image   0.563
CA2
carbonic anhydrase II; Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye (260 aa)
            score_image   0.563
PSMG1
proteasome (prosome, macropain) assembly chaperone 1; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization (288 aa)
            score_image   0.561
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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