node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
B3GNT3 | B4GALT1 | ENSP00000321874 | ENSP00000369055 | UDP-GlcNAc-betaGal beta-1,3-N-acetylglucosaminyltransferase 3; Has a beta-1,3-N-acetylglucosaminyltransferase activity for type 2 oligosaccharides | UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 | 0.919 |
B3GNT3 | B4GALT2 | ENSP00000321874 | ENSP00000310696 | UDP-GlcNAc-betaGal beta-1,3-N-acetylglucosaminyltransferase 3; Has a beta-1,3-N-acetylglucosaminyltransferase activity for type 2 oligosaccharides | UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 | 0.920 |
B3GNT3 | B4GALT4 | ENSP00000321874 | ENSP00000352144 | UDP-GlcNAc-betaGal beta-1,3-N-acetylglucosaminyltransferase 3; Has a beta-1,3-N-acetylglucosaminyltransferase activity for type 2 oligosaccharides | UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4; Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids | 0.919 |
B3GNT3 | C1GALT1C1 | ENSP00000321874 | ENSP00000304364 | UDP-GlcNAc-betaGal beta-1,3-N-acetylglucosaminyltransferase 3; Has a beta-1,3-N-acetylglucosaminyltransferase activity for type 2 oligosaccharides | C1GALT1-specific chaperone 1; Probable chaperone required for the generation of 1 O- glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Probably acts as a specific molecular chaperone assisting the folding/stability of core 1 beta-3-galactosyltransferase (C1GALT1) | 0.965 |
B3GNT3 | FUT3 | ENSP00000321874 | ENSP00000305603 | UDP-GlcNAc-betaGal beta-1,3-N-acetylglucosaminyltransferase 3; Has a beta-1,3-N-acetylglucosaminyltransferase activity for type 2 oligosaccharides | fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group); May catalyze alpha-1,3 and alpha-1,4 glycosidic linkages involved in the expression of Vim-2, Lewis A, Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in blood group Lewis determination; Lewis-positive (Le(+)) individuals have an active enzyme while Lewis-negative (Le(-)) individuals have an inactive enzyme. Also acts on the corresponding 1,4-galactosyl derivative, forming 1,3-L-fucosyl links | 0.915 |
B3GNT3 | FUT4 | ENSP00000321874 | ENSP00000351602 | UDP-GlcNAc-betaGal beta-1,3-N-acetylglucosaminyltransferase 3; Has a beta-1,3-N-acetylglucosaminyltransferase activity for type 2 oligosaccharides | fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific); May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens | 0.917 |
B3GNT3 | FUT6 | ENSP00000321874 | ENSP00000286955 | UDP-GlcNAc-betaGal beta-1,3-N-acetylglucosaminyltransferase 3; Has a beta-1,3-N-acetylglucosaminyltransferase activity for type 2 oligosaccharides | fucosyltransferase 6 (alpha (1,3) fucosyltransferase); Enzyme involved in the biosynthesis of the E-Selectin ligand, sialyl-Lewis X. Catalyzes the transfer of fucose from GDP- beta-fucose to alpha-2,3 sialylated substrates | 0.924 |
B3GNT3 | GCNT2 | ENSP00000321874 | ENSP00000265012 | UDP-GlcNAc-betaGal beta-1,3-N-acetylglucosaminyltransferase 3; Has a beta-1,3-N-acetylglucosaminyltransferase activity for type 2 oligosaccharides | glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group); Branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans. Introduces the blood group I antigen during embryonic development. It is closely associated with the development and maturation of erythroid cells. The expression of the blood group I antigen in erythrocytes is determined by isoform C | 0.923 |
B3GNT3 | GCNT3 | ENSP00000321874 | ENSP00000379377 | UDP-GlcNAc-betaGal beta-1,3-N-acetylglucosaminyltransferase 3; Has a beta-1,3-N-acetylglucosaminyltransferase activity for type 2 oligosaccharides | glucosaminyl (N-acetyl) transferase 3, mucin type; Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Has also I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development | 0.938 |
B3GNT3 | ST3GAL6 | ENSP00000321874 | ENSP00000377717 | UDP-GlcNAc-betaGal beta-1,3-N-acetylglucosaminyltransferase 3; Has a beta-1,3-N-acetylglucosaminyltransferase activity for type 2 oligosaccharides | ST3 beta-galactoside alpha-2,3-sialyltransferase 6; Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant. Has a alpha-2,3- sialyltransferase activity toward Gal-beta1,4-GlcNAc structure on glycoproteins and glycolipids. Has a restricted substrate specificity, it utilizes Gal-beta1,4-GlcNAc on glycoproteins, and neolactotetraosylceramide and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1 | 0.928 |
B4GALT1 | B3GNT3 | ENSP00000369055 | ENSP00000321874 | UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 | UDP-GlcNAc-betaGal beta-1,3-N-acetylglucosaminyltransferase 3; Has a beta-1,3-N-acetylglucosaminyltransferase activity for type 2 oligosaccharides | 0.919 |
B4GALT1 | FUT3 | ENSP00000369055 | ENSP00000305603 | UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 | fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group); May catalyze alpha-1,3 and alpha-1,4 glycosidic linkages involved in the expression of Vim-2, Lewis A, Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in blood group Lewis determination; Lewis-positive (Le(+)) individuals have an active enzyme while Lewis-negative (Le(-)) individuals have an inactive enzyme. Also acts on the corresponding 1,4-galactosyl derivative, forming 1,3-L-fucosyl links | 0.926 |
B4GALT1 | FUT4 | ENSP00000369055 | ENSP00000351602 | UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 | fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific); May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens | 0.910 |
B4GALT1 | FUT6 | ENSP00000369055 | ENSP00000286955 | UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 | fucosyltransferase 6 (alpha (1,3) fucosyltransferase); Enzyme involved in the biosynthesis of the E-Selectin ligand, sialyl-Lewis X. Catalyzes the transfer of fucose from GDP- beta-fucose to alpha-2,3 sialylated substrates | 0.974 |
B4GALT1 | GCNT2 | ENSP00000369055 | ENSP00000265012 | UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 | glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group); Branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans. Introduces the blood group I antigen during embryonic development. It is closely associated with the development and maturation of erythroid cells. The expression of the blood group I antigen in erythrocytes is determined by isoform C | 0.925 |
B4GALT1 | ST3GAL6 | ENSP00000369055 | ENSP00000377717 | UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6; Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant. Has a alpha-2,3- sialyltransferase activity toward Gal-beta1,4-GlcNAc structure on glycoproteins and glycolipids. Has a restricted substrate specificity, it utilizes Gal-beta1,4-GlcNAc on glycoproteins, and neolactotetraosylceramide and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1 | 0.929 |
B4GALT2 | B3GNT3 | ENSP00000310696 | ENSP00000321874 | UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 | UDP-GlcNAc-betaGal beta-1,3-N-acetylglucosaminyltransferase 3; Has a beta-1,3-N-acetylglucosaminyltransferase activity for type 2 oligosaccharides | 0.920 |
B4GALT2 | FUT3 | ENSP00000310696 | ENSP00000305603 | UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 | fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group); May catalyze alpha-1,3 and alpha-1,4 glycosidic linkages involved in the expression of Vim-2, Lewis A, Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in blood group Lewis determination; Lewis-positive (Le(+)) individuals have an active enzyme while Lewis-negative (Le(-)) individuals have an inactive enzyme. Also acts on the corresponding 1,4-galactosyl derivative, forming 1,3-L-fucosyl links | 0.900 |
B4GALT2 | FUT4 | ENSP00000310696 | ENSP00000351602 | UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 | fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific); May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens | 0.906 |
B4GALT2 | FUT6 | ENSP00000310696 | ENSP00000286955 | UDP-Gal-betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 | fucosyltransferase 6 (alpha (1,3) fucosyltransferase); Enzyme involved in the biosynthesis of the E-Selectin ligand, sialyl-Lewis X. Catalyzes the transfer of fucose from GDP- beta-fucose to alpha-2,3 sialylated substrates | 0.900 |