| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C1orf35 | PGA3 | ENSP00000272139 | ENSP00000322192 | chromosome 1 open reading frame 35 | pepsinogen 3, group I (pepsinogen A); Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent | 0.648 |
| CTRB1 | PGA3 | ENSP00000354294 | ENSP00000322192 | chymotrypsinogen B1 | pepsinogen 3, group I (pepsinogen A); Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent | 0.609 |
| CTRB1 | PRSS1 | ENSP00000354294 | ENSP00000308720 | chymotrypsinogen B1 | protease, serine, 1 (trypsin 1) | 0.441 |
| CTRB1 | PRSS3 | ENSP00000354294 | ENSP00000354280 | chymotrypsinogen B1 | protease, serine, 3; Digestive protease specialized for the degradation of trypsin inhibitors. In the ileum, may be involved in defensin processing, including DEFA5 | 0.447 |
| IRF1 | PGA3 | ENSP00000245414 | ENSP00000322192 | interferon regulatory factor 1; Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. These include the regulation of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage. Stimulates both innate and acquired immune responses through the activation of specific target [...] | pepsinogen 3, group I (pepsinogen A); Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent | 0.661 |
| MS4A1 | PGA3 | ENSP00000314620 | ENSP00000322192 | membrane-spanning 4-domains, subfamily A, member 1; This protein may be involved in the regulation of B-cell activation and proliferation | pepsinogen 3, group I (pepsinogen A); Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent | 0.665 |
| PCSK4 | PCSK7 | ENSP00000300954 | ENSP00000325917 | proprotein convertase subtilisin/kexin type 4; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Plays a role in transcriptional coactivation. May be involved in stabilizing the multiprotein transcription complex | proprotein convertase subtilisin/kexin type 7; Likely to represent a ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RXXX[KR]R consensus motif | 0.433 |
| PCSK4 | PGA3 | ENSP00000300954 | ENSP00000322192 | proprotein convertase subtilisin/kexin type 4; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Plays a role in transcriptional coactivation. May be involved in stabilizing the multiprotein transcription complex | pepsinogen 3, group I (pepsinogen A); Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent | 0.606 |
| PCSK5 | PCSK7 | ENSP00000446280 | ENSP00000325917 | proprotein convertase subtilisin/kexin type 5; Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha- integrins | proprotein convertase subtilisin/kexin type 7; Likely to represent a ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RXXX[KR]R consensus motif | 0.402 |
| PCSK5 | PGA3 | ENSP00000446280 | ENSP00000322192 | proprotein convertase subtilisin/kexin type 5; Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha- integrins | pepsinogen 3, group I (pepsinogen A); Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent | 0.554 |
| PCSK7 | PCSK4 | ENSP00000325917 | ENSP00000300954 | proprotein convertase subtilisin/kexin type 7; Likely to represent a ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RXXX[KR]R consensus motif | proprotein convertase subtilisin/kexin type 4; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Plays a role in transcriptional coactivation. May be involved in stabilizing the multiprotein transcription complex | 0.433 |
| PCSK7 | PCSK5 | ENSP00000325917 | ENSP00000446280 | proprotein convertase subtilisin/kexin type 7; Likely to represent a ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RXXX[KR]R consensus motif | proprotein convertase subtilisin/kexin type 5; Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha- integrins | 0.402 |
| PCSK7 | PGA3 | ENSP00000325917 | ENSP00000322192 | proprotein convertase subtilisin/kexin type 7; Likely to represent a ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RXXX[KR]R consensus motif | pepsinogen 3, group I (pepsinogen A); Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent | 0.554 |
| PGA3 | C1orf35 | ENSP00000322192 | ENSP00000272139 | pepsinogen 3, group I (pepsinogen A); Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent | chromosome 1 open reading frame 35 | 0.648 |
| PGA3 | CTRB1 | ENSP00000322192 | ENSP00000354294 | pepsinogen 3, group I (pepsinogen A); Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent | chymotrypsinogen B1 | 0.609 |
| PGA3 | IRF1 | ENSP00000322192 | ENSP00000245414 | pepsinogen 3, group I (pepsinogen A); Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent | interferon regulatory factor 1; Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. These include the regulation of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage. Stimulates both innate and acquired immune responses through the activation of specific target [...] | 0.661 |
| PGA3 | MS4A1 | ENSP00000322192 | ENSP00000314620 | pepsinogen 3, group I (pepsinogen A); Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent | membrane-spanning 4-domains, subfamily A, member 1; This protein may be involved in the regulation of B-cell activation and proliferation | 0.665 |
| PGA3 | PCSK4 | ENSP00000322192 | ENSP00000300954 | pepsinogen 3, group I (pepsinogen A); Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent | proprotein convertase subtilisin/kexin type 4; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Plays a role in transcriptional coactivation. May be involved in stabilizing the multiprotein transcription complex | 0.606 |
| PGA3 | PCSK5 | ENSP00000322192 | ENSP00000446280 | pepsinogen 3, group I (pepsinogen A); Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent | proprotein convertase subtilisin/kexin type 5; Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha- integrins | 0.554 |
| PGA3 | PCSK7 | ENSP00000322192 | ENSP00000325917 | pepsinogen 3, group I (pepsinogen A); Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent | proprotein convertase subtilisin/kexin type 7; Likely to represent a ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RXXX[KR]R consensus motif | 0.554 |
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