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EFCAB4B EFCAB4B TRPM2 TRPM2 STIM1 STIM1 TRPC4 TRPC4 STIM2 STIM2 ORAI1 ORAI1 ORAI3 ORAI3 TRPC3 TRPC3 FKBP1C FKBP1C TRPC1 TRPC1 CCNE1 CCNE1
"ORAI3" - ORAI calcium release-activated calcium modulator 3 in Homo sapiens
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protein of unknown 3D structure
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query proteins and first shell of interactors
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Predicted Interactions
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ORAI3ORAI calcium release-activated calcium modulator 3; Key regulator or component of store-operated Ca(2+) channel and transcription factor NFAT nuclear import (By similarity) (295 aa)    
Predicted Functional Partners:
STIM1
stromal interaction molecule 1; Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, TMEM142A/ORAI1 (685 aa)
        score_image score_image score_image   0.996
STIM2
stromal interaction molecule 2; Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRA [...] (754 aa)
        score_image score_image score_image   0.992
TRPC3
transient receptor potential cation channel, subfamily C, member 3; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5- triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion (921 aa)
        score_image   score_image   0.831
ORAI1
ORAI calcium release-activated calcium modulator 1; Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1. CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT (303 aa)
        score_image   score_image score_image 0.819
CCNE1
cyclin E1; Essential for the control of the cell cycle at the G1/S (start) transition (410 aa)
            score_image   0.779
EFCAB4B
EF-hand calcium binding domain 4B; Ca(2+)-binding protein that plays a key role in store- operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, ther [...] (731 aa)
        score_image   score_image   0.701
TRPC1
transient receptor potential cation channel, subfamily C, member 1; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion (759 aa)
            score_image   0.691
TRPM2
transient receptor potential cation channel, subfamily M, member 2; Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Isoform 2 does not seem to be regulated by ADPR. Has [...] (1503 aa)
            score_image   0.614
FKBP1C
FK506 binding protein 1C (108 aa)
            score_image   0.605
TRPC4
transient receptor potential cation channel, subfamily C, member 4 (982 aa)
            score_image   0.599
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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