LPHN2 protein (Homo sapiens) - STRING network view

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LPHN2

latrophilin 2 (1403 aa)

Predicted Functional Partners:

MGAT1

0.887

SHANK2

0.824

SLC35C1

0.680

SLC35C2

0.672

SHANK1

0.659

TAPBPL

0.623

DENND4A

0.608

CDO1

0.607

PPAPDC1A

0.561

REEP2

0.543

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDO1	LPHN2	ENSP00000250535	ENSP00000322270	cysteine dioxygenase, type I; Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range	latrophilin 2	0.607
CDO1	REEP2	ENSP00000250535	ENSP00000254901	cysteine dioxygenase, type I; Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range	receptor accessory protein 2; May enhance the cell surface expression of odorant receptors (By similarity)	0.567
DENND4A	LPHN2	ENSP00000391167	ENSP00000322270	DENN/MADD domain containing 4A; Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form. According to PubMed-8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter	latrophilin 2	0.608
LPHN2	CDO1	ENSP00000322270	ENSP00000250535	latrophilin 2	cysteine dioxygenase, type I; Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range	0.607
LPHN2	DENND4A	ENSP00000322270	ENSP00000391167	latrophilin 2	DENN/MADD domain containing 4A; Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form. According to PubMed-8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter	0.608
LPHN2	MGAT1	ENSP00000322270	ENSP00000311888	latrophilin 2	mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase; Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans	0.887
LPHN2	PPAPDC1A	ENSP00000322270	ENSP00000381302	latrophilin 2	phosphatidic acid phosphatase type 2 domain containing 1A; Displays magnesium-independent phosphatidate phosphatase activity in vitro. Catalyzes the conversion of phosphatidic acid to diacylglycerol	0.561
LPHN2	REEP2	ENSP00000322270	ENSP00000254901	latrophilin 2	receptor accessory protein 2; May enhance the cell surface expression of odorant receptors (By similarity)	0.543
LPHN2	SHANK1	ENSP00000322270	ENSP00000293441	latrophilin 2	SH3 and multiple ankyrin repeat domains 1; Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction	0.659
LPHN2	SHANK2	ENSP00000322270	ENSP00000345193	latrophilin 2	SH3 and multiple ankyrin repeat domains 2; Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction	0.824
LPHN2	SLC35C1	ENSP00000322270	ENSP00000313318	latrophilin 2	solute carrier family 35, member C1; Involved in GDP-fucose import from the cytoplasm into the Golgi lumen	0.680
LPHN2	SLC35C2	ENSP00000322270	ENSP00000243896	latrophilin 2	solute carrier family 35, member C2; May play an important role in the cellular response to tissue hypoxia	0.672
LPHN2	TAPBPL	ENSP00000322270	ENSP00000266556	latrophilin 2	TAP binding protein-like	0.623
MGAT1	LPHN2	ENSP00000311888	ENSP00000322270	mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase; Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans	latrophilin 2	0.887
PPAPDC1A	LPHN2	ENSP00000381302	ENSP00000322270	phosphatidic acid phosphatase type 2 domain containing 1A; Displays magnesium-independent phosphatidate phosphatase activity in vitro. Catalyzes the conversion of phosphatidic acid to diacylglycerol	latrophilin 2	0.561
REEP2	CDO1	ENSP00000254901	ENSP00000250535	receptor accessory protein 2; May enhance the cell surface expression of odorant receptors (By similarity)	cysteine dioxygenase, type I; Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range	0.567
REEP2	LPHN2	ENSP00000254901	ENSP00000322270	receptor accessory protein 2; May enhance the cell surface expression of odorant receptors (By similarity)	latrophilin 2	0.543
SHANK1	LPHN2	ENSP00000293441	ENSP00000322270	SH3 and multiple ankyrin repeat domains 1; Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction	latrophilin 2	0.659
SHANK2	LPHN2	ENSP00000345193	ENSP00000322270	SH3 and multiple ankyrin repeat domains 2; Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction	latrophilin 2	0.824
SLC35C1	LPHN2	ENSP00000313318	ENSP00000322270	solute carrier family 35, member C1; Involved in GDP-fucose import from the cytoplasm into the Golgi lumen	latrophilin 2	0.680

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