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STRINGSTRING
PHTF1 PHTF1 AP4B1 AP4B1 DENND2C DENND2C RSBN1 RSBN1 CSDE1 CSDE1 MYLK2 MYLK2 OLFML3 OLFML3 MYOC MYOC RIOK2 RIOK2 ISOC1 ISOC1
"OLFML3" - olfactomedin-like 3 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
OLFML3olfactomedin-like 3; Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity). May have matrix-related function involved in placental and embryonic development, or play a similar role in other physiological processes (406 aa)    
Predicted Functional Partners:
CSDE1
cold shock domain containing E1, RNA-binding (844 aa)
            score_image   0.503
RIOK2
RIO kinase 2 (yeast) (552 aa)
            score_image   0.483
ISOC1
isochorismatase domain containing 1 (298 aa)
            score_image   0.482
DENND2C
DENN/MADD domain containing 2C; Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form (871 aa)
            score_image   0.477
MYOC
myocilin, trabecular meshwork inducible glucocorticoid response; May participate in the obstruction of fluid outflow in the trabecular meshwork (504 aa)
        score_image   score_image score_image 0.436
AP4B1
adaptor-related protein complex 4, beta 1 subunit; Subunit of novel type of clathrin- or non-clathrin- associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system (739 aa)
            score_image   0.432
RSBN1
round spermatid basic protein 1 (802 aa)
            score_image   0.427
PHTF1
putative homeodomain transcription factor 1; May play a role in transcription regulation (762 aa)
            score_image   0.425
MYLK2
myosin light chain kinase 2; Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N- terminus of a myosin light chain (596 aa)
            score_image   0.422
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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