node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AP4B1 | OLFML3 | ENSP00000256658 | ENSP00000322273 | adaptor-related protein complex 4, beta 1 subunit; Subunit of novel type of clathrin- or non-clathrin- associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system | olfactomedin-like 3; Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity). May have matrix-related function involved in placental and embryonic development, or play a similar role in other physiological processes | 0.432 |
AP4B1 | PHTF1 | ENSP00000256658 | ENSP00000358617 | adaptor-related protein complex 4, beta 1 subunit; Subunit of novel type of clathrin- or non-clathrin- associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system | putative homeodomain transcription factor 1; May play a role in transcription regulation | 0.529 |
AP4B1 | RSBN1 | ENSP00000256658 | ENSP00000261441 | adaptor-related protein complex 4, beta 1 subunit; Subunit of novel type of clathrin- or non-clathrin- associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system | round spermatid basic protein 1 | 0.531 |
CSDE1 | DENND2C | ENSP00000407724 | ENSP00000376957 | cold shock domain containing E1, RNA-binding | DENN/MADD domain containing 2C; Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form | 0.537 |
CSDE1 | MYLK2 | ENSP00000407724 | ENSP00000365152 | cold shock domain containing E1, RNA-binding | myosin light chain kinase 2; Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N- terminus of a myosin light chain | 0.456 |
CSDE1 | OLFML3 | ENSP00000407724 | ENSP00000322273 | cold shock domain containing E1, RNA-binding | olfactomedin-like 3; Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity). May have matrix-related function involved in placental and embryonic development, or play a similar role in other physiological processes | 0.503 |
DENND2C | CSDE1 | ENSP00000376957 | ENSP00000407724 | DENN/MADD domain containing 2C; Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form | cold shock domain containing E1, RNA-binding | 0.537 |
DENND2C | MYLK2 | ENSP00000376957 | ENSP00000365152 | DENN/MADD domain containing 2C; Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form | myosin light chain kinase 2; Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N- terminus of a myosin light chain | 0.473 |
DENND2C | OLFML3 | ENSP00000376957 | ENSP00000322273 | DENN/MADD domain containing 2C; Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form | olfactomedin-like 3; Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity). May have matrix-related function involved in placental and embryonic development, or play a similar role in other physiological processes | 0.477 |
ISOC1 | OLFML3 | ENSP00000173527 | ENSP00000322273 | isochorismatase domain containing 1 | olfactomedin-like 3; Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity). May have matrix-related function involved in placental and embryonic development, or play a similar role in other physiological processes | 0.482 |
ISOC1 | RIOK2 | ENSP00000173527 | ENSP00000283109 | isochorismatase domain containing 1 | RIO kinase 2 (yeast) | 0.610 |
MYLK2 | CSDE1 | ENSP00000365152 | ENSP00000407724 | myosin light chain kinase 2; Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N- terminus of a myosin light chain | cold shock domain containing E1, RNA-binding | 0.456 |
MYLK2 | DENND2C | ENSP00000365152 | ENSP00000376957 | myosin light chain kinase 2; Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N- terminus of a myosin light chain | DENN/MADD domain containing 2C; Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form | 0.473 |
MYLK2 | OLFML3 | ENSP00000365152 | ENSP00000322273 | myosin light chain kinase 2; Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N- terminus of a myosin light chain | olfactomedin-like 3; Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity). May have matrix-related function involved in placental and embryonic development, or play a similar role in other physiological processes | 0.422 |
MYOC | OLFML3 | ENSP00000037502 | ENSP00000322273 | myocilin, trabecular meshwork inducible glucocorticoid response; May participate in the obstruction of fluid outflow in the trabecular meshwork | olfactomedin-like 3; Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity). May have matrix-related function involved in placental and embryonic development, or play a similar role in other physiological processes | 0.436 |
OLFML3 | AP4B1 | ENSP00000322273 | ENSP00000256658 | olfactomedin-like 3; Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity). May have matrix-related function involved in placental and embryonic development, or play a similar role in other physiological processes | adaptor-related protein complex 4, beta 1 subunit; Subunit of novel type of clathrin- or non-clathrin- associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system | 0.432 |
OLFML3 | CSDE1 | ENSP00000322273 | ENSP00000407724 | olfactomedin-like 3; Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity). May have matrix-related function involved in placental and embryonic development, or play a similar role in other physiological processes | cold shock domain containing E1, RNA-binding | 0.503 |
OLFML3 | DENND2C | ENSP00000322273 | ENSP00000376957 | olfactomedin-like 3; Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity). May have matrix-related function involved in placental and embryonic development, or play a similar role in other physiological processes | DENN/MADD domain containing 2C; Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form | 0.477 |
OLFML3 | ISOC1 | ENSP00000322273 | ENSP00000173527 | olfactomedin-like 3; Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity). May have matrix-related function involved in placental and embryonic development, or play a similar role in other physiological processes | isochorismatase domain containing 1 | 0.482 |
OLFML3 | MYLK2 | ENSP00000322273 | ENSP00000365152 | olfactomedin-like 3; Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity). May have matrix-related function involved in placental and embryonic development, or play a similar role in other physiological processes | myosin light chain kinase 2; Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N- terminus of a myosin light chain | 0.422 |