| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ALDH7A1 | PCBP4 | ENSP00000387123 | ENSP00000322341 | aldehyde dehydrogenase 7 family, member A1; Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism | poly(rC) binding protein 4; Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (By similarity) | 0.552 |
| ALDH7A1 | UBC | ENSP00000387123 | ENSP00000344818 | aldehyde dehydrogenase 7 family, member A1; Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism | ubiquitin C | 0.592 |
| ATXN2 | PCBP4 | ENSP00000366843 | ENSP00000322341 | ataxin 2; Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane | poly(rC) binding protein 4; Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (By similarity) | 0.565 |
| ATXN2 | UBC | ENSP00000366843 | ENSP00000344818 | ataxin 2; Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane | ubiquitin C | 0.929 |
| CSNK1G1 | PCBP4 | ENSP00000305777 | ENSP00000322341 | casein kinase 1, gamma 1; Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). Phosphorylates CLSPN | poly(rC) binding protein 4; Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (By similarity) | 0.675 |
| CSNK1G1 | TP53 | ENSP00000305777 | ENSP00000269305 | casein kinase 1, gamma 1; Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). Phosphorylates CLSPN | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | 0.900 |
| CSNK1G1 | UBC | ENSP00000305777 | ENSP00000344818 | casein kinase 1, gamma 1; Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). Phosphorylates CLSPN | ubiquitin C | 0.897 |
| CSNK1G2 | PCBP4 | ENSP00000255641 | ENSP00000322341 | casein kinase 1, gamma 2; Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteas [...] | poly(rC) binding protein 4; Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (By similarity) | 0.684 |
| CSNK1G2 | TP53 | ENSP00000255641 | ENSP00000269305 | casein kinase 1, gamma 2; Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteas [...] | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | 0.900 |
| CSNK1G2 | UBC | ENSP00000255641 | ENSP00000344818 | casein kinase 1, gamma 2; Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteas [...] | ubiquitin C | 0.860 |
| CSNK1G3 | PCBP4 | ENSP00000353904 | ENSP00000322341 | casein kinase 1, gamma 3; Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity) | poly(rC) binding protein 4; Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (By similarity) | 0.675 |
| CSNK1G3 | TP53 | ENSP00000353904 | ENSP00000269305 | casein kinase 1, gamma 3; Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity) | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | 0.900 |
| CSNK1G3 | UBC | ENSP00000353904 | ENSP00000344818 | casein kinase 1, gamma 3; Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity) | ubiquitin C | 0.924 |
| LYST | PCBP4 | ENSP00000374443 | ENSP00000322341 | lysosomal trafficking regulator; May be required for sorting endosomal resident proteins into late multivesicular endosomes by a mechanism involving microtubules | poly(rC) binding protein 4; Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (By similarity) | 0.550 |
| LYST | UBC | ENSP00000374443 | ENSP00000344818 | lysosomal trafficking regulator; May be required for sorting endosomal resident proteins into late multivesicular endosomes by a mechanism involving microtubules | ubiquitin C | 0.541 |
| LYST | VTA1 | ENSP00000374443 | ENSP00000356602 | lysosomal trafficking regulator; May be required for sorting endosomal resident proteins into late multivesicular endosomes by a mechanism involving microtubules | Vps20-associated 1 homolog (S. cerevisiae); Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR (By similarity). Involved in HIV-1 budding | 0.865 |
| PCBP4 | ALDH7A1 | ENSP00000322341 | ENSP00000387123 | poly(rC) binding protein 4; Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (By similarity) | aldehyde dehydrogenase 7 family, member A1; Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism | 0.552 |
| PCBP4 | ATXN2 | ENSP00000322341 | ENSP00000366843 | poly(rC) binding protein 4; Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (By similarity) | ataxin 2; Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane | 0.565 |
| PCBP4 | CSNK1G1 | ENSP00000322341 | ENSP00000305777 | poly(rC) binding protein 4; Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (By similarity) | casein kinase 1, gamma 1; Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). Phosphorylates CLSPN | 0.675 |
| PCBP4 | CSNK1G2 | ENSP00000322341 | ENSP00000255641 | poly(rC) binding protein 4; Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (By similarity) | casein kinase 1, gamma 2; Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteas [...] | 0.684 |
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