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POLE4 POLE4 POLD1 POLD1 MCM2 MCM2 POLE3 POLE3 POLE2 POLE2 PCNA PCNA MSH2 MSH2 POLA1 POLA1 POLE POLE REV3L REV3L PRIM1 PRIM1
"POLE" - polymerase (DNA directed), epsilon, catalytic subunit in Homo sapiens
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protein of unknown 3D structure
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POLEpolymerase (DNA directed), epsilon, catalytic subunit; Participates in DNA repair and in chromosomal DNA replication (2286 aa)    
Predicted Functional Partners:
POLE2
polymerase (DNA directed), epsilon 2, accessory subunit; Participates in DNA repair and in chromosomal DNA replication (527 aa)
      score_image score_image score_image score_image   0.999
PCNA
proliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase’s processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3’- 5’ exonuclease and 3’-phosphodiesterase, but not apurinic- apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA re [...] (261 aa)
      score_image score_image score_image score_image   0.999
POLE3
polymerase (DNA directed), epsilon 3, accessory subunit; Forms a complex with DNA polymerase epsilon subunit CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1 (147 aa)
        score_image score_image score_image   0.999
POLA1
polymerase (DNA directed), alpha 1, catalytic subunit; Plays an essential role in the initiation of DNA replication. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1/p180, a regulatory subunit POLA2/p70 and two primase subunits PRIM1/p49 and PRIM2/p58) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by [...] (1462 aa)
      score_image score_image score_image score_image   0.999
POLE4
polymerase (DNA-directed), epsilon 4, accessory subunit; May play a role in allowing polymerase epsilon to carry out its replication and/or repair function (117 aa)
        score_image score_image score_image   0.997
MSH2
mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli); Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers- MutS alpha (MSH2- MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, [...] (934 aa)
      score_image score_image score_image score_image   0.997
PRIM1
primase, DNA, polypeptide 1 (49kDa); DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication (420 aa)
      score_image score_image score_image score_image   0.996
MCM2
minichromosome maintenance complex component 2; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for ’once per cell cycle’ DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute dif [...] (904 aa)
      score_image score_image score_image score_image   0.996
POLD1
polymerase (DNA directed), delta 1, catalytic subunit; Possesses two enzymatic activities- DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3’- to 5’-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex (1107 aa)
      score_image score_image score_image score_image   0.995
REV3L
REV3-like, polymerase (DNA directed), zeta, catalytic subunit; Interacts with MAD2L2 to form the error prone DNA polymerase zeta involved in translesion DNA synthesis (3130 aa)
      score_image score_image score_image score_image   0.993
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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