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RHBDL1 RHBDL1 PDE6H PDE6H PARL PARL ADAM17 ADAM17 RHBDF2 RHBDF2 CD109 CD109 CPS1 CPS1 UBC UBC NPRL3 NPRL3 CSTB CSTB POLR3K POLR3K
"RHBDF2" - rhomboid 5 homolog 2 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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Predicted Interactions
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RHBDF2rhomboid 5 homolog 2 (Drosophila); Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor. Indirectly activates the epidermal growth factor receptor signaling pathway and may thereby regulate sleep, cell survival, proliferation and migration (By similarity) (856 aa)    
Predicted Functional Partners:
ADAM17
ADAM metallopeptidase domain 17; Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Also involved in the activation of Notch pathway (By similarity) (824 aa)
            score_image   0.861
PDE6H
phosphodiesterase 6H, cGMP-specific, cone, gamma; Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones (83 aa)
            score_image   0.685
UBC
ubiquitin C (685 aa)
        score_image   score_image   0.631
RHBDL1
rhomboid, veinlet-like 1 (Drosophila); May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors (By similarity) (438 aa)
            score_image   0.595
CPS1
carbamoyl-phosphate synthase 1, mitochondrial; Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell (1506 aa)
score_image           score_image   0.590
NPRL3
nitrogen permease regulator-like 3 (S. cerevisiae) (568 aa)
            score_image   0.575
CD109
CD109 molecule (1445 aa)
            score_image   0.560
POLR3K
polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein [...] (108 aa)
            score_image   0.547
PARL
presenilin associated, rhomboid-like; Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptoptic signals (By similarity). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain (379 aa)
            score_image   0.497
CSTB
cystatin B (stefin B); This is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B (98 aa)
            score_image   0.497
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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