node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FARP1 | HAPLN1 | ENSP00000322926 | ENSP00000274341 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived); Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity) | hyaluronan and proteoglycan link protein 1; Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix | 0.400 |
FARP1 | PLEK | ENSP00000322926 | ENSP00000234313 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived); Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity) | pleckstrin; Major protein kinase C substrate of platelets | 0.440 |
FARP1 | RHOA | ENSP00000322926 | ENSP00000400175 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived); Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity) | ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disor [...] | 0.907 |
FARP1 | RNF113B | ENSP00000322926 | ENSP00000267291 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived); Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity) | ring finger protein 113B | 0.459 |
FARP1 | UBC | ENSP00000322926 | ENSP00000344818 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived); Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity) | ubiquitin C | 0.483 |
HAPLN1 | FARP1 | ENSP00000274341 | ENSP00000322926 | hyaluronan and proteoglycan link protein 1; Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived); Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity) | 0.400 |
PLEK | FARP1 | ENSP00000234313 | ENSP00000322926 | pleckstrin; Major protein kinase C substrate of platelets | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived); Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity) | 0.440 |
PLEK | RHOA | ENSP00000234313 | ENSP00000400175 | pleckstrin; Major protein kinase C substrate of platelets | ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disor [...] | 0.659 |
PLEK | UBC | ENSP00000234313 | ENSP00000344818 | pleckstrin; Major protein kinase C substrate of platelets | ubiquitin C | 0.522 |
RHOA | FARP1 | ENSP00000400175 | ENSP00000322926 | ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disor [...] | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived); Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity) | 0.907 |
RHOA | PLEK | ENSP00000400175 | ENSP00000234313 | ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disor [...] | pleckstrin; Major protein kinase C substrate of platelets | 0.659 |
RHOA | UBC | ENSP00000400175 | ENSP00000344818 | ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disor [...] | ubiquitin C | 0.999 |
RNF113B | FARP1 | ENSP00000267291 | ENSP00000322926 | ring finger protein 113B | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived); Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity) | 0.459 |
UBC | FARP1 | ENSP00000344818 | ENSP00000322926 | ubiquitin C | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived); Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity) | 0.483 |
UBC | PLEK | ENSP00000344818 | ENSP00000234313 | ubiquitin C | pleckstrin; Major protein kinase C substrate of platelets | 0.522 |
UBC | RHOA | ENSP00000344818 | ENSP00000400175 | ubiquitin C | ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disor [...] | 0.999 |