GTP protein (Homo sapiens) - STRING network view

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Score

GTP

Mitochondrial GTPase 1 ; Mitochondrial GTPase. May be involved in assembly of the large ribosomal subunit (By similarity) (334 aa)

Predicted Functional Partners:

GTPBP4

0.886

SPRN

0.870

PPP1R11

0.772

LSG1

0.767

RPS15A

0.687

MALSU1

0.664

MRPL39

0.658

PAOX

0.639

MRPS5

0.611

PES1

0.610

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GTP	GTPBP4	ENSP00000323047	ENSP00000354040	Mitochondrial GTPase 1 ; Mitochondrial GTPase. May be involved in assembly of the large ribosomal subunit (By similarity)	GTP binding protein 4; Involved in the biogenesis of the 60S ribosomal subunit (By similarity)	0.886
GTP	LSG1	ENSP00000323047	ENSP00000265245	Mitochondrial GTPase 1 ; Mitochondrial GTPase. May be involved in assembly of the large ribosomal subunit (By similarity)	large subunit GTPase 1 homolog (S. cerevisiae); GTPase required for the XPO1/CRM1-mediated nuclear export of the 60S ribosomal subunit. Probably acts by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm (Probable)	0.767
GTP	MALSU1	ENSP00000323047	ENSP00000419370	Mitochondrial GTPase 1 ; Mitochondrial GTPase. May be involved in assembly of the large ribosomal subunit (By similarity)	mitochondrial assembly of ribosomal large subunit 1; May function as a ribosomal silencing factor. Addition to isolated mitochondrial ribosomal subunits partially inhibits translation. Interacts with mitochondrial ribosomal protein L14 (MRPL14), probably blocking formation of intersubunit bridge B8, preventing association of the 28S and 39S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. May also participate in the assembly and/or regulation of the stability of the large subunit of the mitochondrial ribosome	0.664
GTP	MRPL39	ENSP00000323047	ENSP00000305682	Mitochondrial GTPase 1 ; Mitochondrial GTPase. May be involved in assembly of the large ribosomal subunit (By similarity)	mitochondrial ribosomal protein L39	0.658
GTP	MRPS5	ENSP00000323047	ENSP00000272418	Mitochondrial GTPase 1 ; Mitochondrial GTPase. May be involved in assembly of the large ribosomal subunit (By similarity)	mitochondrial ribosomal protein S5	0.611
GTP	PAOX	ENSP00000323047	ENSP00000278060	Mitochondrial GTPase 1 ; Mitochondrial GTPase. May be involved in assembly of the large ribosomal subunit (By similarity)	polyamine oxidase (exo-N4-amino)	0.639
GTP	PES1	ENSP00000323047	ENSP00000346725	Mitochondrial GTPase 1 ; Mitochondrial GTPase. May be involved in assembly of the large ribosomal subunit (By similarity)	pescadillo ribosomal biogenesis factor 1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome	0.610
GTP	PPP1R11	ENSP00000323047	ENSP00000365963	Mitochondrial GTPase 1 ; Mitochondrial GTPase. May be involved in assembly of the large ribosomal subunit (By similarity)	protein phosphatase 1, regulatory (inhibitor) subunit 11	0.772
GTP	RPS15A	ENSP00000323047	ENSP00000318646	Mitochondrial GTPase 1 ; Mitochondrial GTPase. May be involved in assembly of the large ribosomal subunit (By similarity)	ribosomal protein S15a	0.687
GTP	SPRN	ENSP00000323047	ENSP00000433712	Mitochondrial GTPase 1 ; Mitochondrial GTPase. May be involved in assembly of the large ribosomal subunit (By similarity)	shadow of prion protein homolog (zebrafish); Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP (By similarity)	0.870
GTPBP4	GTP	ENSP00000354040	ENSP00000323047	GTP binding protein 4; Involved in the biogenesis of the 60S ribosomal subunit (By similarity)	Mitochondrial GTPase 1 ; Mitochondrial GTPase. May be involved in assembly of the large ribosomal subunit (By similarity)	0.886
GTPBP4	LSG1	ENSP00000354040	ENSP00000265245	GTP binding protein 4; Involved in the biogenesis of the 60S ribosomal subunit (By similarity)	large subunit GTPase 1 homolog (S. cerevisiae); GTPase required for the XPO1/CRM1-mediated nuclear export of the 60S ribosomal subunit. Probably acts by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm (Probable)	0.953
GTPBP4	PES1	ENSP00000354040	ENSP00000346725	GTP binding protein 4; Involved in the biogenesis of the 60S ribosomal subunit (By similarity)	pescadillo ribosomal biogenesis factor 1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome	0.999
GTPBP4	SPRN	ENSP00000354040	ENSP00000433712	GTP binding protein 4; Involved in the biogenesis of the 60S ribosomal subunit (By similarity)	shadow of prion protein homolog (zebrafish); Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP (By similarity)	0.688
LSG1	GTP	ENSP00000265245	ENSP00000323047	large subunit GTPase 1 homolog (S. cerevisiae); GTPase required for the XPO1/CRM1-mediated nuclear export of the 60S ribosomal subunit. Probably acts by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm (Probable)	Mitochondrial GTPase 1 ; Mitochondrial GTPase. May be involved in assembly of the large ribosomal subunit (By similarity)	0.767
LSG1	GTPBP4	ENSP00000265245	ENSP00000354040	large subunit GTPase 1 homolog (S. cerevisiae); GTPase required for the XPO1/CRM1-mediated nuclear export of the 60S ribosomal subunit. Probably acts by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm (Probable)	GTP binding protein 4; Involved in the biogenesis of the 60S ribosomal subunit (By similarity)	0.953
LSG1	MRPS5	ENSP00000265245	ENSP00000272418	large subunit GTPase 1 homolog (S. cerevisiae); GTPase required for the XPO1/CRM1-mediated nuclear export of the 60S ribosomal subunit. Probably acts by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm (Probable)	mitochondrial ribosomal protein S5	0.422
LSG1	PES1	ENSP00000265245	ENSP00000346725	large subunit GTPase 1 homolog (S. cerevisiae); GTPase required for the XPO1/CRM1-mediated nuclear export of the 60S ribosomal subunit. Probably acts by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm (Probable)	pescadillo ribosomal biogenesis factor 1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome	0.942
MALSU1	GTP	ENSP00000419370	ENSP00000323047	mitochondrial assembly of ribosomal large subunit 1; May function as a ribosomal silencing factor. Addition to isolated mitochondrial ribosomal subunits partially inhibits translation. Interacts with mitochondrial ribosomal protein L14 (MRPL14), probably blocking formation of intersubunit bridge B8, preventing association of the 28S and 39S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. May also participate in the assembly and/or regulation of the stability of the large subunit of the mitochondrial ribosome	Mitochondrial GTPase 1 ; Mitochondrial GTPase. May be involved in assembly of the large ribosomal subunit (By similarity)	0.664
MRPL39	GTP	ENSP00000305682	ENSP00000323047	mitochondrial ribosomal protein L39	Mitochondrial GTPase 1 ; Mitochondrial GTPase. May be involved in assembly of the large ribosomal subunit (By similarity)	0.658

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