NDUFAF3 protein (Homo sapiens) - STRING network view

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NDUFAF3

NADH dehydrogenase (ubiquinone) complex I, assembly factor 3; Essential factor for the assembly of mitochondrial NADH-ubiquinone oxidoreductase complex (complex I) (184 aa)

Predicted Functional Partners:

NDUFAF4

0.999

NDUFS2

0.999

NDUFS3

0.999

CYC1

0.938

NDUFS4

0.903

NDUFS8

0.818

NDUFAF5

0.743

ITM2C

0.720

NDUFAF1

0.717

EIF4A2

0.700

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CYC1	NDUFAF3	ENSP00000317159	ENSP00000323076	cytochrome c-1; This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain	NADH dehydrogenase (ubiquinone) complex I, assembly factor 3; Essential factor for the assembly of mitochondrial NADH-ubiquinone oxidoreductase complex (complex I)	0.938
CYC1	NDUFS2	ENSP00000317159	ENSP00000356972	cytochrome c-1; This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain	NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase); Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)	0.978
CYC1	NDUFS3	ENSP00000317159	ENSP00000263774	cytochrome c-1; This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain	NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase); Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)	0.951
CYC1	NDUFS4	ENSP00000317159	ENSP00000296684	cytochrome c-1; This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain	NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase); Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone	0.993
CYC1	NDUFS8	ENSP00000317159	ENSP00000315774	cytochrome c-1; This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain	NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase); Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). May donate electrons to ubiquinone	0.996
EIF4A2	ITM2C	ENSP00000326381	ENSP00000322730	eukaryotic translation initiation factor 4A2; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5’-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon	integral membrane protein 2C	0.632
EIF4A2	NDUFAF3	ENSP00000326381	ENSP00000323076	eukaryotic translation initiation factor 4A2; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5’-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon	NADH dehydrogenase (ubiquinone) complex I, assembly factor 3; Essential factor for the assembly of mitochondrial NADH-ubiquinone oxidoreductase complex (complex I)	0.700
ITM2C	EIF4A2	ENSP00000322730	ENSP00000326381	integral membrane protein 2C	eukaryotic translation initiation factor 4A2; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5’-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon	0.632
ITM2C	NDUFAF3	ENSP00000322730	ENSP00000323076	integral membrane protein 2C	NADH dehydrogenase (ubiquinone) complex I, assembly factor 3; Essential factor for the assembly of mitochondrial NADH-ubiquinone oxidoreductase complex (complex I)	0.720
NDUFAF1	NDUFAF3	ENSP00000260361	ENSP00000323076	NADH dehydrogenase (ubiquinone) complex I, assembly factor 1; Chaperone protein involved in the assembly of the mitochondrial NADH-ubiquinone oxidoreductase complex (complex I) (By similarity)	NADH dehydrogenase (ubiquinone) complex I, assembly factor 3; Essential factor for the assembly of mitochondrial NADH-ubiquinone oxidoreductase complex (complex I)	0.717
NDUFAF1	NDUFAF4	ENSP00000260361	ENSP00000358272	NADH dehydrogenase (ubiquinone) complex I, assembly factor 1; Chaperone protein involved in the assembly of the mitochondrial NADH-ubiquinone oxidoreductase complex (complex I) (By similarity)	NADH dehydrogenase (ubiquinone) complex I, assembly factor 4; Involved in the assembly of mitochondrial NADH-ubiquinone oxidoreductase complex (complex I). May be involved in cell proliferation and survival of hormone-dependent tumor cells. May be a regulator of breast tumor cell invasion	0.657
NDUFAF1	NDUFAF5	ENSP00000260361	ENSP00000367346	NADH dehydrogenase (ubiquinone) complex I, assembly factor 1; Chaperone protein involved in the assembly of the mitochondrial NADH-ubiquinone oxidoreductase complex (complex I) (By similarity)	NADH dehydrogenase (ubiquinone) complex I, assembly factor 5; Involved in the assembly of mitochondrial NADH-ubiquinone oxidoreductase complex (complex I, MT-ND1) at early stages. May have methyltransferase activity	0.737
NDUFAF1	NDUFS2	ENSP00000260361	ENSP00000356972	NADH dehydrogenase (ubiquinone) complex I, assembly factor 1; Chaperone protein involved in the assembly of the mitochondrial NADH-ubiquinone oxidoreductase complex (complex I) (By similarity)	NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase); Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)	0.969
NDUFAF1	NDUFS3	ENSP00000260361	ENSP00000263774	NADH dehydrogenase (ubiquinone) complex I, assembly factor 1; Chaperone protein involved in the assembly of the mitochondrial NADH-ubiquinone oxidoreductase complex (complex I) (By similarity)	NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase); Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)	0.982
NDUFAF1	NDUFS4	ENSP00000260361	ENSP00000296684	NADH dehydrogenase (ubiquinone) complex I, assembly factor 1; Chaperone protein involved in the assembly of the mitochondrial NADH-ubiquinone oxidoreductase complex (complex I) (By similarity)	NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase); Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone	0.966
NDUFAF1	NDUFS8	ENSP00000260361	ENSP00000315774	NADH dehydrogenase (ubiquinone) complex I, assembly factor 1; Chaperone protein involved in the assembly of the mitochondrial NADH-ubiquinone oxidoreductase complex (complex I) (By similarity)	NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase); Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). May donate electrons to ubiquinone	0.964
NDUFAF3	CYC1	ENSP00000323076	ENSP00000317159	NADH dehydrogenase (ubiquinone) complex I, assembly factor 3; Essential factor for the assembly of mitochondrial NADH-ubiquinone oxidoreductase complex (complex I)	cytochrome c-1; This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain	0.938
NDUFAF3	EIF4A2	ENSP00000323076	ENSP00000326381	NADH dehydrogenase (ubiquinone) complex I, assembly factor 3; Essential factor for the assembly of mitochondrial NADH-ubiquinone oxidoreductase complex (complex I)	eukaryotic translation initiation factor 4A2; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5’-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon	0.700
NDUFAF3	ITM2C	ENSP00000323076	ENSP00000322730	NADH dehydrogenase (ubiquinone) complex I, assembly factor 3; Essential factor for the assembly of mitochondrial NADH-ubiquinone oxidoreductase complex (complex I)	integral membrane protein 2C	0.720
NDUFAF3	NDUFAF1	ENSP00000323076	ENSP00000260361	NADH dehydrogenase (ubiquinone) complex I, assembly factor 3; Essential factor for the assembly of mitochondrial NADH-ubiquinone oxidoreductase complex (complex I)	NADH dehydrogenase (ubiquinone) complex I, assembly factor 1; Chaperone protein involved in the assembly of the mitochondrial NADH-ubiquinone oxidoreductase complex (complex I) (By similarity)	0.717

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