| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APAF1 | CDC6 | ENSP00000448165 | ENSP00000209728 | apoptotic peptidase activating factor 1 | cell division cycle 6 homolog (S. cerevisiae); Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated | 0.855 |
| APAF1 | CDKN1A | ENSP00000448165 | ENSP00000244741 | apoptotic peptidase activating factor 1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1); May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin- dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D- CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex | 0.599 |
| APAF1 | E2F1 | ENSP00000448165 | ENSP00000345571 | apoptotic peptidase activating factor 1 | E2F transcription factor 1; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5’-TTTC[CG]CGC- 3’ found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis | 0.928 |
| APAF1 | E2F7 | ENSP00000448165 | ENSP00000323246 | apoptotic peptidase activating factor 1 | E2F transcription factor 7; Atypical E2F transcription factor that participates to various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5’- TTTC[CG]CGC-3’. Directly represses transcription of classical E2F transcription factors such as E2F1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5’-TTCCCGCC-3’ and mediating repression of G1/S-regulated genes. Plays a key role in [...] | 0.915 |
| CCNE2 | CDC6 | ENSP00000309181 | ENSP00000209728 | cyclin E2; Essential for the control of the cell cycle at the late G1 and early S phase | cell division cycle 6 homolog (S. cerevisiae); Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated | 0.738 |
| CCNE2 | CDKN1A | ENSP00000309181 | ENSP00000244741 | cyclin E2; Essential for the control of the cell cycle at the late G1 and early S phase | cyclin-dependent kinase inhibitor 1A (p21, Cip1); May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin- dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D- CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex | 0.999 |
| CCNE2 | E2F1 | ENSP00000309181 | ENSP00000345571 | cyclin E2; Essential for the control of the cell cycle at the late G1 and early S phase | E2F transcription factor 1; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5’-TTTC[CG]CGC- 3’ found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis | 0.981 |
| CCNE2 | E2F7 | ENSP00000309181 | ENSP00000323246 | cyclin E2; Essential for the control of the cell cycle at the late G1 and early S phase | E2F transcription factor 7; Atypical E2F transcription factor that participates to various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5’- TTTC[CG]CGC-3’. Directly represses transcription of classical E2F transcription factors such as E2F1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5’-TTCCCGCC-3’ and mediating repression of G1/S-regulated genes. Plays a key role in [...] | 0.930 |
| CCNE2 | RBL1 | ENSP00000309181 | ENSP00000362768 | cyclin E2; Essential for the control of the cell cycle at the late G1 and early S phase | retinoblastoma-like 1 (p107); Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 ’Lys-20’ trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with [...] | 0.725 |
| CCNE2 | TFDP3 | ENSP00000309181 | ENSP00000385461 | cyclin E2; Essential for the control of the cell cycle at the late G1 and early S phase | transcription factor Dp family, member 3; Competitive inhibitor of E2F-mediated transactivation activity. Impairs E2F-mediated cell-cycle progression from G(1) to S phase | 0.513 |
| CDC6 | APAF1 | ENSP00000209728 | ENSP00000448165 | cell division cycle 6 homolog (S. cerevisiae); Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated | apoptotic peptidase activating factor 1 | 0.855 |
| CDC6 | CCNE2 | ENSP00000209728 | ENSP00000309181 | cell division cycle 6 homolog (S. cerevisiae); Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated | cyclin E2; Essential for the control of the cell cycle at the late G1 and early S phase | 0.738 |
| CDC6 | CDKN1A | ENSP00000209728 | ENSP00000244741 | cell division cycle 6 homolog (S. cerevisiae); Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated | cyclin-dependent kinase inhibitor 1A (p21, Cip1); May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin- dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D- CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex | 0.995 |
| CDC6 | E2F1 | ENSP00000209728 | ENSP00000345571 | cell division cycle 6 homolog (S. cerevisiae); Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated | E2F transcription factor 1; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5’-TTTC[CG]CGC- 3’ found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis | 0.988 |
| CDC6 | E2F7 | ENSP00000209728 | ENSP00000323246 | cell division cycle 6 homolog (S. cerevisiae); Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated | E2F transcription factor 7; Atypical E2F transcription factor that participates to various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5’- TTTC[CG]CGC-3’. Directly represses transcription of classical E2F transcription factors such as E2F1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5’-TTCCCGCC-3’ and mediating repression of G1/S-regulated genes. Plays a key role in [...] | 0.981 |
| CDC6 | RBL1 | ENSP00000209728 | ENSP00000362768 | cell division cycle 6 homolog (S. cerevisiae); Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated | retinoblastoma-like 1 (p107); Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 ’Lys-20’ trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with [...] | 0.972 |
| CDC6 | TFDP3 | ENSP00000209728 | ENSP00000385461 | cell division cycle 6 homolog (S. cerevisiae); Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated | transcription factor Dp family, member 3; Competitive inhibitor of E2F-mediated transactivation activity. Impairs E2F-mediated cell-cycle progression from G(1) to S phase | 0.419 |
| CDKN1A | APAF1 | ENSP00000244741 | ENSP00000448165 | cyclin-dependent kinase inhibitor 1A (p21, Cip1); May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin- dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D- CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex | apoptotic peptidase activating factor 1 | 0.599 |
| CDKN1A | CCNE2 | ENSP00000244741 | ENSP00000309181 | cyclin-dependent kinase inhibitor 1A (p21, Cip1); May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin- dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D- CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex | cyclin E2; Essential for the control of the cell cycle at the late G1 and early S phase | 0.999 |
| CDKN1A | CDC6 | ENSP00000244741 | ENSP00000209728 | cyclin-dependent kinase inhibitor 1A (p21, Cip1); May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin- dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D- CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex | cell division cycle 6 homolog (S. cerevisiae); Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated | 0.995 |
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