node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCDC59 | MRTO4 | ENSP00000256151 | ENSP00000364320 | coiled-coil domain containing 59; Component of the transcription complexes of the pulmonary surfactant-associated protein-B (SFTPB) and -C (SFTPC). Enhances homeobox protein Nkx-2.1-activated SFTPB and SFTPC promoter activities | mRNA turnover 4 homolog (S. cerevisiae); Involved in mRNA turnover and ribosome assembly (By similarity) | 0.586 |
CCDC59 | RPUSD2 | ENSP00000256151 | ENSP00000323288 | coiled-coil domain containing 59; Component of the transcription complexes of the pulmonary surfactant-associated protein-B (SFTPB) and -C (SFTPC). Enhances homeobox protein Nkx-2.1-activated SFTPB and SFTPC promoter activities | RNA pseudouridylate synthase domain containing 2 | 0.611 |
CCDC59 | SNAPC3 | ENSP00000256151 | ENSP00000370200 | coiled-coil domain containing 59; Component of the transcription complexes of the pulmonary surfactant-associated protein-B (SFTPB) and -C (SFTPC). Enhances homeobox protein Nkx-2.1-activated SFTPB and SFTPC promoter activities | small nuclear RNA activating complex, polypeptide 3, 50kDa; Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box | 0.583 |
DNAJC17 | RPUSD2 | ENSP00000220496 | ENSP00000323288 | DnaJ (Hsp40) homolog, subfamily C, member 17 | RNA pseudouridylate synthase domain containing 2 | 0.779 |
EFTUD2 | MRTO4 | ENSP00000392094 | ENSP00000364320 | elongation factor Tu GTP binding domain containing 2; Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex required for pre-mRNA splicing. Binds GTP | mRNA turnover 4 homolog (S. cerevisiae); Involved in mRNA turnover and ribosome assembly (By similarity) | 0.871 |
EFTUD2 | RPUSD2 | ENSP00000392094 | ENSP00000323288 | elongation factor Tu GTP binding domain containing 2; Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex required for pre-mRNA splicing. Binds GTP | RNA pseudouridylate synthase domain containing 2 | 0.597 |
MRTO4 | CCDC59 | ENSP00000364320 | ENSP00000256151 | mRNA turnover 4 homolog (S. cerevisiae); Involved in mRNA turnover and ribosome assembly (By similarity) | coiled-coil domain containing 59; Component of the transcription complexes of the pulmonary surfactant-associated protein-B (SFTPB) and -C (SFTPC). Enhances homeobox protein Nkx-2.1-activated SFTPB and SFTPC promoter activities | 0.586 |
MRTO4 | EFTUD2 | ENSP00000364320 | ENSP00000392094 | mRNA turnover 4 homolog (S. cerevisiae); Involved in mRNA turnover and ribosome assembly (By similarity) | elongation factor Tu GTP binding domain containing 2; Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex required for pre-mRNA splicing. Binds GTP | 0.871 |
MRTO4 | RPUSD2 | ENSP00000364320 | ENSP00000323288 | mRNA turnover 4 homolog (S. cerevisiae); Involved in mRNA turnover and ribosome assembly (By similarity) | RNA pseudouridylate synthase domain containing 2 | 0.610 |
MRTO4 | RPUSD3 | ENSP00000364320 | ENSP00000373331 | mRNA turnover 4 homolog (S. cerevisiae); Involved in mRNA turnover and ribosome assembly (By similarity) | RNA pseudouridylate synthase domain containing 3 | 0.418 |
MRTO4 | SNAPC3 | ENSP00000364320 | ENSP00000370200 | mRNA turnover 4 homolog (S. cerevisiae); Involved in mRNA turnover and ribosome assembly (By similarity) | small nuclear RNA activating complex, polypeptide 3, 50kDa; Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box | 0.564 |
PUS10 | RPUSD2 | ENSP00000326003 | ENSP00000323288 | pseudouridylate synthase 10; Pseudouridylate synthases catalyze pseudouridination of structural RNAs, including transfer, ribosomal, and splicing RNAs. PUS10 catalyzes the formation of the universal psi55 in the GC loop of transfer RNAs (Probable). Modulator of TRAIL-induced cell death via activation of procaspase 8 and BID cleavage. Required for the progression of the apoptotic signal through intrinsic mitochondrial cell death | RNA pseudouridylate synthase domain containing 2 | 0.660 |
QTRTD1 | RPUSD2 | ENSP00000281273 | ENSP00000323288 | queuine tRNA-ribosyltransferase domain containing 1; Interacts with QTRT1 to form an active queuine tRNA- ribosyltransferase. This enzyme exchanges queuine for the guanine at the wobble position of tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), thereby forming the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1- yl)amino)methyl)-7-deazaguanosine) (By similarity) | RNA pseudouridylate synthase domain containing 2 | 0.601 |
QTRTD1 | RPUSD3 | ENSP00000281273 | ENSP00000373331 | queuine tRNA-ribosyltransferase domain containing 1; Interacts with QTRT1 to form an active queuine tRNA- ribosyltransferase. This enzyme exchanges queuine for the guanine at the wobble position of tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), thereby forming the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1- yl)amino)methyl)-7-deazaguanosine) (By similarity) | RNA pseudouridylate synthase domain containing 3 | 0.610 |
QTRTD1 | THUMPD3 | ENSP00000281273 | ENSP00000339532 | queuine tRNA-ribosyltransferase domain containing 1; Interacts with QTRT1 to form an active queuine tRNA- ribosyltransferase. This enzyme exchanges queuine for the guanine at the wobble position of tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), thereby forming the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1- yl)amino)methyl)-7-deazaguanosine) (By similarity) | THUMP domain containing 3 | 0.701 |
QTRTD1 | TRUB2 | ENSP00000281273 | ENSP00000361982 | queuine tRNA-ribosyltransferase domain containing 1; Interacts with QTRT1 to form an active queuine tRNA- ribosyltransferase. This enzyme exchanges queuine for the guanine at the wobble position of tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), thereby forming the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1- yl)amino)methyl)-7-deazaguanosine) (By similarity) | TruB pseudouridine (psi) synthase homolog 2 (E. coli); May be responsible for synthesis of pseudouridine from uracil in transfer RNAs (By similarity) | 0.618 |
RPUSD2 | CCDC59 | ENSP00000323288 | ENSP00000256151 | RNA pseudouridylate synthase domain containing 2 | coiled-coil domain containing 59; Component of the transcription complexes of the pulmonary surfactant-associated protein-B (SFTPB) and -C (SFTPC). Enhances homeobox protein Nkx-2.1-activated SFTPB and SFTPC promoter activities | 0.611 |
RPUSD2 | DNAJC17 | ENSP00000323288 | ENSP00000220496 | RNA pseudouridylate synthase domain containing 2 | DnaJ (Hsp40) homolog, subfamily C, member 17 | 0.779 |
RPUSD2 | EFTUD2 | ENSP00000323288 | ENSP00000392094 | RNA pseudouridylate synthase domain containing 2 | elongation factor Tu GTP binding domain containing 2; Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex required for pre-mRNA splicing. Binds GTP | 0.597 |
RPUSD2 | MRTO4 | ENSP00000323288 | ENSP00000364320 | RNA pseudouridylate synthase domain containing 2 | mRNA turnover 4 homolog (S. cerevisiae); Involved in mRNA turnover and ribosome assembly (By similarity) | 0.610 |