Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | C2CD3 | C2 calcium-dependent domain containing 3 (1963 aa) | ||||||||||||
Predicted Functional Partners:
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 | CEP76 | centrosomal protein 76kDa; Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication (659 aa) |
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0.611 | ||||||||||
 | RHOT1 | ras homolog family member T1; Mitochondrial GTPase involved in mitochondrial trafficking (By similarity) (691 aa) |
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0.570 | ||||||||||
 | MAST2 | microtubule associated serine/threonine kinase 2; Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity) (1798 aa) |
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0.520 | ||||||||||
 | CC2D2B | coiled-coil and C2 domain containing 2B (401 aa) |
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0.507 | ||||||||||
 | TBC1D30 | TBC1 domain family, member 30; GTPase-activating protein (GAP) with broad specificity. Acts as a GAP for RAB3A. Also exhibits significant GAP activity toward RAB22A, RAB27A, and RAB35 in vitro (761 aa) |
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0.504 | ||||||||||
 | RHOT2 | ras homolog family member T2; Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity) (618 aa) |
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0.497 | ||||||||||
 | UBC | ubiquitin C (685 aa) |
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0.483 | ||||||||||
 | CCDC41 | coiled-coil domain containing 41 (701 aa) |
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0.471 | ||||||||||
 | ANKS6 | ankyrin repeat and sterile alpha motif domain containing 6 (871 aa) |
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0.471 | ||||||||||
 | ARL6IP4 | ADP-ribosylation-like factor 6 interacting protein 4; In case of infection by Herpes simplex virus (HSVI), may act as a splicing inhibitor of HSVI pre-mRNA (360 aa) |
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0.457 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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