Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | SNX22 | sorting nexin 22; May be involved in several stages of intracellular trafficking (By similarity). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (193 aa) | ||||||||||||
Predicted Functional Partners:
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 | CSNK1A1 | casein kinase 1, alpha 1 (365 aa) |
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0.738 | ||||||||||
 | CCDC111 | coiled-coil domain containing 111 (560 aa) |
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0.715 | ||||||||||
 | CSNK1E | casein kinase 1, epsilon; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm. Inhibits cytokine-induced granuloytic differentiation (416 aa) |
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0.617 | ||||||||||
 | C3orf18 | chromosome 3 open reading frame 18 (162 aa) |
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0.592 | ||||||||||
 | RHBDD1 | rhomboid domain containing 1; Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions. Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded membrane proteins. Required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the trans [...] (315 aa) |
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0.591 | ||||||||||
 | C11orf70 | chromosome 11 open reading frame 70 (267 aa) |
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0.591 | ||||||||||
 | CRLF3 | cytokine receptor-like factor 3; May play a role in the negative regulation of cell cycle progression (442 aa) |
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0.584 | ||||||||||
 | PARP11 | poly (ADP-ribose) polymerase family, member 11 (338 aa) |
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0.579 | ||||||||||
 | ARMC1 | armadillo repeat containing 1 (282 aa) |
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0.578 | ||||||||||
 | FCF1 | FCF1 small subunit (SSU) processome component homolog (S. cerevisiae); Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly (By similarity) (198 aa) |
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0.505 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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