| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| COPG2 | MKLN1 | ENSP00000393912 | ENSP00000323527 | coatomer protein complex, subunit gamma 2 | muskelin 1, intracellular mediator containing kelch motifs; Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1 (By similarity) | 0.595 |
| GID8 | MKLN1 | ENSP00000266069 | ENSP00000323527 | GID complex subunit 8 homolog (S. cerevisiae) | muskelin 1, intracellular mediator containing kelch motifs; Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1 (By similarity) | 0.941 |
| GID8 | MPHOSPH8 | ENSP00000266069 | ENSP00000355388 | GID complex subunit 8 homolog (S. cerevisiae) | M-phase phosphoprotein 8; Involved in transcriptional regulation. Specifically recognizes and binds methylated ’Lys-9’ of histone H3 (H3K9me) and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene. Mediates down-regulation of CDH1 expression | 0.868 |
| GID8 | RANBP10 | ENSP00000266069 | ENSP00000316589 | GID complex subunit 8 homolog (S. cerevisiae) | RAN binding protein 10; Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase (By similarity). May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function (By similarity). May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen- induced transactivation. In contrast to RANBP9, does not interact with Sos [...] | 0.772 |
| GID8 | RANBP9 | ENSP00000266069 | ENSP00000011619 | GID complex subunit 8 homolog (S. cerevisiae) | RAN binding protein 9; May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. May be involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation. Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity. Inhibits the kinase activity o [...] | 0.976 |
| GID8 | RMND5A | ENSP00000266069 | ENSP00000283632 | GID complex subunit 8 homolog (S. cerevisiae) | required for meiotic nuclear division 5 homolog A (S. cerevisiae) | 0.992 |
| GID8 | SPRYD3 | ENSP00000266069 | ENSP00000301463 | GID complex subunit 8 homolog (S. cerevisiae) | SPRY domain containing 3 | 0.688 |
| KLHL2 | MKLN1 | ENSP00000424198 | ENSP00000323527 | kelch-like 2, Mayven (Drosophila); Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation (By similarity). Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors | muskelin 1, intracellular mediator containing kelch motifs; Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1 (By similarity) | 0.634 |
| KLHL2 | RMND5A | ENSP00000424198 | ENSP00000283632 | kelch-like 2, Mayven (Drosophila); Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation (By similarity). Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors | required for meiotic nuclear division 5 homolog A (S. cerevisiae) | 0.676 |
| MKLN1 | COPG2 | ENSP00000323527 | ENSP00000393912 | muskelin 1, intracellular mediator containing kelch motifs; Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1 (By similarity) | coatomer protein complex, subunit gamma 2 | 0.595 |
| MKLN1 | GID8 | ENSP00000323527 | ENSP00000266069 | muskelin 1, intracellular mediator containing kelch motifs; Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1 (By similarity) | GID complex subunit 8 homolog (S. cerevisiae) | 0.941 |
| MKLN1 | KLHL2 | ENSP00000323527 | ENSP00000424198 | muskelin 1, intracellular mediator containing kelch motifs; Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1 (By similarity) | kelch-like 2, Mayven (Drosophila); Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation (By similarity). Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors | 0.634 |
| MKLN1 | MPHOSPH8 | ENSP00000323527 | ENSP00000355388 | muskelin 1, intracellular mediator containing kelch motifs; Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1 (By similarity) | M-phase phosphoprotein 8; Involved in transcriptional regulation. Specifically recognizes and binds methylated ’Lys-9’ of histone H3 (H3K9me) and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene. Mediates down-regulation of CDH1 expression | 0.860 |
| MKLN1 | PTGER3 | ENSP00000323527 | ENSP00000349003 | muskelin 1, intracellular mediator containing kelch motifs; Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1 (By similarity) | prostaglandin E receptor 3 (subtype EP3); Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second me [...] | 0.604 |
| MKLN1 | RANBP10 | ENSP00000323527 | ENSP00000316589 | muskelin 1, intracellular mediator containing kelch motifs; Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1 (By similarity) | RAN binding protein 10; Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase (By similarity). May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function (By similarity). May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen- induced transactivation. In contrast to RANBP9, does not interact with Sos [...] | 0.730 |
| MKLN1 | RANBP9 | ENSP00000323527 | ENSP00000011619 | muskelin 1, intracellular mediator containing kelch motifs; Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1 (By similarity) | RAN binding protein 9; May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. May be involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation. Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity. Inhibits the kinase activity o [...] | 0.996 |
| MKLN1 | RMND5A | ENSP00000323527 | ENSP00000283632 | muskelin 1, intracellular mediator containing kelch motifs; Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1 (By similarity) | required for meiotic nuclear division 5 homolog A (S. cerevisiae) | 0.937 |
| MKLN1 | SPRYD3 | ENSP00000323527 | ENSP00000301463 | muskelin 1, intracellular mediator containing kelch motifs; Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1 (By similarity) | SPRY domain containing 3 | 0.687 |
| MKLN1 | TM9SF4 | ENSP00000323527 | ENSP00000381104 | muskelin 1, intracellular mediator containing kelch motifs; Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1 (By similarity) | transmembrane 9 superfamily protein member 4 | 0.594 |
| MPHOSPH8 | GID8 | ENSP00000355388 | ENSP00000266069 | M-phase phosphoprotein 8; Involved in transcriptional regulation. Specifically recognizes and binds methylated ’Lys-9’ of histone H3 (H3K9me) and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene. Mediates down-regulation of CDH1 expression | GID complex subunit 8 homolog (S. cerevisiae) | 0.868 |
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