ZADH2 protein (Homo sapiens) - STRING network view

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ZADH2

zinc binding alcohol dehydrogenase domain containing 2 (377 aa)

Predicted Functional Partners:

C18orf62

0.810

CRYZL1

0.755

XYLB

0.578

MECR

0.558

PEX5

0.533

TYSND1

0.527

QPCTL

0.523

ARMC6

0.520

SYTL3

0.512

ADHFE1

0.511

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADHFE1	ARMC6	ENSP00000379865	ENSP00000376148	alcohol dehydrogenase, iron containing, 1; Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2- hydroxyglutarate (D-2-HG). D,L-3-hydroxyisobutyrate and L-3- hydroxybutyrate (L-3-OHB) are also substrates for HOT with 10-fold lower activities	armadillo repeat containing 6	0.621
ADHFE1	QPCTL	ENSP00000379865	ENSP00000012049	alcohol dehydrogenase, iron containing, 1; Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2- hydroxyglutarate (D-2-HG). D,L-3-hydroxyisobutyrate and L-3- hydroxybutyrate (L-3-OHB) are also substrates for HOT with 10-fold lower activities	glutaminyl-peptide cyclotransferase-like; Responsible for the biosynthesis of pyroglutamyl peptides	0.500
ADHFE1	SYTL3	ENSP00000379865	ENSP00000297239	alcohol dehydrogenase, iron containing, 1; Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2- hydroxyglutarate (D-2-HG). D,L-3-hydroxyisobutyrate and L-3- hydroxybutyrate (L-3-OHB) are also substrates for HOT with 10-fold lower activities	synaptotagmin-like 3; May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids in the presence of calcium ions (By similarity)	0.489
ADHFE1	ZADH2	ENSP00000379865	ENSP00000323678	alcohol dehydrogenase, iron containing, 1; Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2- hydroxyglutarate (D-2-HG). D,L-3-hydroxyisobutyrate and L-3- hydroxybutyrate (L-3-OHB) are also substrates for HOT with 10-fold lower activities	zinc binding alcohol dehydrogenase domain containing 2	0.511
ARMC6	ADHFE1	ENSP00000376148	ENSP00000379865	armadillo repeat containing 6	alcohol dehydrogenase, iron containing, 1; Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2- hydroxyglutarate (D-2-HG). D,L-3-hydroxyisobutyrate and L-3- hydroxybutyrate (L-3-OHB) are also substrates for HOT with 10-fold lower activities	0.621
ARMC6	QPCTL	ENSP00000376148	ENSP00000012049	armadillo repeat containing 6	glutaminyl-peptide cyclotransferase-like; Responsible for the biosynthesis of pyroglutamyl peptides	0.579
ARMC6	SYTL3	ENSP00000376148	ENSP00000297239	armadillo repeat containing 6	synaptotagmin-like 3; May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids in the presence of calcium ions (By similarity)	0.636
ARMC6	ZADH2	ENSP00000376148	ENSP00000323678	armadillo repeat containing 6	zinc binding alcohol dehydrogenase domain containing 2	0.520
C18orf62	ZADH2	ENSP00000462106	ENSP00000323678	chromosome 18 open reading frame 62	zinc binding alcohol dehydrogenase domain containing 2	0.810
CRYZL1	MECR	ENSP00000370966	ENSP00000263702	crystallin, zeta (quinone reductase)-like 1	mitochondrial trans-2-enoyl-CoA reductase; Catalyzes the reduction of trans-2-enoyl-CoA to acyl-CoA with chain length from C6 to C16 in an NADPH-dependent manner with preference to medium chain length substrate. May have a role in the mitochondrial synthesis of fatty acids	0.468
CRYZL1	XYLB	ENSP00000370966	ENSP00000207870	crystallin, zeta (quinone reductase)-like 1	xylulokinase homolog (H. influenzae); Phosphorylates D-xylulose to produce D-xylulose 5- phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis	0.607
CRYZL1	ZADH2	ENSP00000370966	ENSP00000323678	crystallin, zeta (quinone reductase)-like 1	zinc binding alcohol dehydrogenase domain containing 2	0.755
MECR	CRYZL1	ENSP00000263702	ENSP00000370966	mitochondrial trans-2-enoyl-CoA reductase; Catalyzes the reduction of trans-2-enoyl-CoA to acyl-CoA with chain length from C6 to C16 in an NADPH-dependent manner with preference to medium chain length substrate. May have a role in the mitochondrial synthesis of fatty acids	crystallin, zeta (quinone reductase)-like 1	0.468
MECR	ZADH2	ENSP00000263702	ENSP00000323678	mitochondrial trans-2-enoyl-CoA reductase; Catalyzes the reduction of trans-2-enoyl-CoA to acyl-CoA with chain length from C6 to C16 in an NADPH-dependent manner with preference to medium chain length substrate. May have a role in the mitochondrial synthesis of fatty acids	zinc binding alcohol dehydrogenase domain containing 2	0.558
PEX5	TYSND1	ENSP00000407401	ENSP00000287078	peroxisomal biogenesis factor 5; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import	trypsin domain containing 1; Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta- oxidation of fatty acids	0.764
PEX5	ZADH2	ENSP00000407401	ENSP00000323678	peroxisomal biogenesis factor 5; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import	zinc binding alcohol dehydrogenase domain containing 2	0.533
QPCTL	ADHFE1	ENSP00000012049	ENSP00000379865	glutaminyl-peptide cyclotransferase-like; Responsible for the biosynthesis of pyroglutamyl peptides	alcohol dehydrogenase, iron containing, 1; Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2- hydroxyglutarate (D-2-HG). D,L-3-hydroxyisobutyrate and L-3- hydroxybutyrate (L-3-OHB) are also substrates for HOT with 10-fold lower activities	0.500
QPCTL	ARMC6	ENSP00000012049	ENSP00000376148	glutaminyl-peptide cyclotransferase-like; Responsible for the biosynthesis of pyroglutamyl peptides	armadillo repeat containing 6	0.579
QPCTL	SYTL3	ENSP00000012049	ENSP00000297239	glutaminyl-peptide cyclotransferase-like; Responsible for the biosynthesis of pyroglutamyl peptides	synaptotagmin-like 3; May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids in the presence of calcium ions (By similarity)	0.530
QPCTL	ZADH2	ENSP00000012049	ENSP00000323678	glutaminyl-peptide cyclotransferase-like; Responsible for the biosynthesis of pyroglutamyl peptides	zinc binding alcohol dehydrogenase domain containing 2	0.523

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