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STRINGSTRING
IP6K2 IP6K2 IPMK IPMK KDM4C KDM4C PPIP5K1 PPIP5K1 ITPKA ITPKA IPPK IPPK IP6K1 IP6K1 ITPK1 ITPK1 EXOSC7 EXOSC7 IP6K3 IP6K3 NUDT4 NUDT4
"IP6K1" - inositol hexakisphosphate kinase 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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IP6K1inositol hexakisphosphate kinase 1; Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 (441 aa)    
Predicted Functional Partners:
PPIP5K1
diphosphoinositol pentakisphosphate kinase 1 (1433 aa)
          score_image score_image   0.983
IPPK
inositol 1,3,4,5,6-pentakisphosphate 2-kinase; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis (491 aa)
          score_image score_image   0.947
NUDT4
nudix (nucleoside diphosphate linked moiety X)-type motif 4 (181 aa)
          score_image score_image   0.932
IPMK
inositol polyphosphate multikinase; Inositol phosphate kinase with a broad substrate specificity. Has a preference for inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4) (416 aa)
          score_image score_image score_image 0.917
IP6K2
inositol hexakisphosphate kinase 2 (426 aa)
          score_image score_image score_image 0.904
IP6K3
inositol hexakisphosphate kinase 3; Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 (410 aa)
          score_image score_image score_image 0.904
ITPK1
inositol-tetrakisphosphate 1-kinase; Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate I [...] (414 aa)
          score_image score_image   0.900
EXOSC7
exosome component 7; Non-catalytic component of the RNA exosome complex which has 3’->5’ exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding ’pervasive’ transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The R [...] (291 aa)
        score_image   score_image   0.833
KDM4C
lysine (K)-specific demethylase 4C (1056 aa)
            score_image   0.805
ITPKA
inositol-trisphosphate 3-kinase A (461 aa)
            score_image   0.741
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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