node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACLY | ARL14 | ENSP00000253792 | ENSP00000323847 | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | ADP-ribosylation factor-like 14; GTPase that recruits MYO1E to MHC class II-containing vesicles via the effector protein ARL14EP and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells | 0.621 |
ARFGAP2 | ARL14 | ENSP00000434442 | ENSP00000323847 | ADP-ribosylation factor GTPase activating protein 2; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes | ADP-ribosylation factor-like 14; GTPase that recruits MYO1E to MHC class II-containing vesicles via the effector protein ARL14EP and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells | 0.615 |
ARFGAP2 | ENSG00000262633 | ENSP00000434442 | ENSP00000461460 | ADP-ribosylation factor GTPase activating protein 2; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes | Golgi SNAP receptor complex member 2; Uncharacterized protein | 0.767 |
ARFGAP2 | GBF1 | ENSP00000434442 | ENSP00000359000 | ADP-ribosylation factor GTPase activating protein 2; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes | golgi brefeldin A resistant guanine nucleotide exchange factor 1; Promotes guanine-nucleotide exchange on ARF5. Promotes the activation of ARF5 through replacement of GDP with GTP (By similarity) | 0.459 |
ARFGAP2 | GOSR2 | ENSP00000434442 | ENSP00000225567 | ADP-ribosylation factor GTPase activating protein 2; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes | golgi SNAP receptor complex member 2; Involved in transport of proteins from the cis/medial- Golgi to the trans-Golgi network | 0.767 |
ARFGAP3 | ARL14 | ENSP00000263245 | ENSP00000323847 | ADP-ribosylation factor GTPase activating protein 3; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes | ADP-ribosylation factor-like 14; GTPase that recruits MYO1E to MHC class II-containing vesicles via the effector protein ARL14EP and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells | 0.615 |
ARFGAP3 | ENSG00000262633 | ENSP00000263245 | ENSP00000461460 | ADP-ribosylation factor GTPase activating protein 3; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes | Golgi SNAP receptor complex member 2; Uncharacterized protein | 0.772 |
ARFGAP3 | GBF1 | ENSP00000263245 | ENSP00000359000 | ADP-ribosylation factor GTPase activating protein 3; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes | golgi brefeldin A resistant guanine nucleotide exchange factor 1; Promotes guanine-nucleotide exchange on ARF5. Promotes the activation of ARF5 through replacement of GDP with GTP (By similarity) | 0.460 |
ARFGAP3 | GOSR2 | ENSP00000263245 | ENSP00000225567 | ADP-ribosylation factor GTPase activating protein 3; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes | golgi SNAP receptor complex member 2; Involved in transport of proteins from the cis/medial- Golgi to the trans-Golgi network | 0.775 |
ARL14 | ACLY | ENSP00000323847 | ENSP00000253792 | ADP-ribosylation factor-like 14; GTPase that recruits MYO1E to MHC class II-containing vesicles via the effector protein ARL14EP and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | 0.621 |
ARL14 | ARFGAP2 | ENSP00000323847 | ENSP00000434442 | ADP-ribosylation factor-like 14; GTPase that recruits MYO1E to MHC class II-containing vesicles via the effector protein ARL14EP and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells | ADP-ribosylation factor GTPase activating protein 2; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes | 0.615 |
ARL14 | ARFGAP3 | ENSP00000323847 | ENSP00000263245 | ADP-ribosylation factor-like 14; GTPase that recruits MYO1E to MHC class II-containing vesicles via the effector protein ARL14EP and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells | ADP-ribosylation factor GTPase activating protein 3; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes | 0.615 |
ARL14 | ARL14EP | ENSP00000323847 | ENSP00000282032 | ADP-ribosylation factor-like 14; GTPase that recruits MYO1E to MHC class II-containing vesicles via the effector protein ARL14EP and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells | ADP-ribosylation factor-like 14 effector protein; Through its interaction with ARL14 and MYO1E, may connect MHC class II-containing cytoplasmic vesicles to the actin network and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells | 0.776 |
ARL14 | ENSG00000262633 | ENSP00000323847 | ENSP00000461460 | ADP-ribosylation factor-like 14; GTPase that recruits MYO1E to MHC class II-containing vesicles via the effector protein ARL14EP and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells | Golgi SNAP receptor complex member 2; Uncharacterized protein | 0.626 |
ARL14 | ENSG00000267261 | ENSP00000323847 | ENSP00000468367 | ADP-ribosylation factor-like 14; GTPase that recruits MYO1E to MHC class II-containing vesicles via the effector protein ARL14EP and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells | Ras-related protein Rab-5C | 0.580 |
ARL14 | GBF1 | ENSP00000323847 | ENSP00000359000 | ADP-ribosylation factor-like 14; GTPase that recruits MYO1E to MHC class II-containing vesicles via the effector protein ARL14EP and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells | golgi brefeldin A resistant guanine nucleotide exchange factor 1; Promotes guanine-nucleotide exchange on ARF5. Promotes the activation of ARF5 through replacement of GDP with GTP (By similarity) | 0.642 |
ARL14 | GOSR2 | ENSP00000323847 | ENSP00000225567 | ADP-ribosylation factor-like 14; GTPase that recruits MYO1E to MHC class II-containing vesicles via the effector protein ARL14EP and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells | golgi SNAP receptor complex member 2; Involved in transport of proteins from the cis/medial- Golgi to the trans-Golgi network | 0.626 |
ARL14 | PIP5K1A | ENSP00000323847 | ENSP00000357883 | ADP-ribosylation factor-like 14; GTPase that recruits MYO1E to MHC class II-containing vesicles via the effector protein ARL14EP and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha; Catalyzes the phosphorylation of phosphatidylinositol 4- phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as actin cytoskeleton organ [...] | 0.671 |
ARL14 | PSD4 | ENSP00000323847 | ENSP00000245796 | ADP-ribosylation factor-like 14; GTPase that recruits MYO1E to MHC class II-containing vesicles via the effector protein ARL14EP and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells | pleckstrin and Sec7 domain containing 4; Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5- bisphosphate and phosphatidylinositol 4,5-bisphosphate | 0.628 |
ARL14EP | ARL14 | ENSP00000282032 | ENSP00000323847 | ADP-ribosylation factor-like 14 effector protein; Through its interaction with ARL14 and MYO1E, may connect MHC class II-containing cytoplasmic vesicles to the actin network and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells | ADP-ribosylation factor-like 14; GTPase that recruits MYO1E to MHC class II-containing vesicles via the effector protein ARL14EP and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells | 0.776 |