PLXDC1 protein (Homo sapiens) - STRING network view

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PLXDC1

plexin domain containing 1; Plays a critical role in endothelial cell capillary morphogenesis (By similarity) (500 aa)

Predicted Functional Partners:

CD248

0.906

RASD2

0.896

GPR124

0.878

ANTXR1

0.852

ARHGEF17

0.847

TNS3

0.821

CAPZA1

0.700

NID1

0.648

CDIPT

0.635

OXA1L

0.634

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANTXR1	ARHGEF17	ENSP00000301945	ENSP00000263674	anthrax toxin receptor 1; Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells	Rho guanine nucleotide exchange factor (GEF) 17; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases	0.681
ANTXR1	CAPZA1	ENSP00000301945	ENSP00000263168	anthrax toxin receptor 1; Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells	capping protein (actin filament) muscle Z-line, alpha 1; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments	0.474
ANTXR1	CD248	ENSP00000301945	ENSP00000308117	anthrax toxin receptor 1; Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells	CD248 molecule, endosialin; May play a role in tumor angiogenesis	0.767
ANTXR1	GPR124	ENSP00000301945	ENSP00000406367	anthrax toxin receptor 1; Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells	G protein-coupled receptor 124; Endothelial receptor that acts as an essential regulator of CNS angiogenesis. Required for normal endothelial cell sprouting and migration in the forebrain and neural tube (By similarity)	0.669
ANTXR1	PLXDC1	ENSP00000301945	ENSP00000323927	anthrax toxin receptor 1; Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells	plexin domain containing 1; Plays a critical role in endothelial cell capillary morphogenesis (By similarity)	0.852
ANTXR1	RASD2	ENSP00000301945	ENSP00000216127	anthrax toxin receptor 1; Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells	RASD family, member 2; GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected striatal competencies, mainly locomotor activity and motor coordination	0.628
ANTXR1	TNS3	ENSP00000301945	ENSP00000312143	anthrax toxin receptor 1; Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells	tensin 3; May play a role in actin remodeling. Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Seems to be involved in mammary cell migration. May be involved in cell migration and bone development (By similarity)	0.779
ARHGEF17	ANTXR1	ENSP00000263674	ENSP00000301945	Rho guanine nucleotide exchange factor (GEF) 17; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases	anthrax toxin receptor 1; Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells	0.681
ARHGEF17	CAPZA1	ENSP00000263674	ENSP00000263168	Rho guanine nucleotide exchange factor (GEF) 17; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases	capping protein (actin filament) muscle Z-line, alpha 1; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments	0.513
ARHGEF17	CD248	ENSP00000263674	ENSP00000308117	Rho guanine nucleotide exchange factor (GEF) 17; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases	CD248 molecule, endosialin; May play a role in tumor angiogenesis	0.814
ARHGEF17	CDIPT	ENSP00000263674	ENSP00000219789	Rho guanine nucleotide exchange factor (GEF) 17; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases	CDP-diacylglycerol--inositol 3-phosphatidyltransferase; Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns-inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme	0.480
ARHGEF17	GPR124	ENSP00000263674	ENSP00000406367	Rho guanine nucleotide exchange factor (GEF) 17; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases	G protein-coupled receptor 124; Endothelial receptor that acts as an essential regulator of CNS angiogenesis. Required for normal endothelial cell sprouting and migration in the forebrain and neural tube (By similarity)	0.814
ARHGEF17	OXA1L	ENSP00000263674	ENSP00000285848	Rho guanine nucleotide exchange factor (GEF) 17; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases	oxidase (cytochrome c) assembly 1-like; Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome oxidase. Required for the correct biogenesis of ATP synthase and complex I in mitochondria	0.457
ARHGEF17	PLXDC1	ENSP00000263674	ENSP00000323927	Rho guanine nucleotide exchange factor (GEF) 17; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases	plexin domain containing 1; Plays a critical role in endothelial cell capillary morphogenesis (By similarity)	0.847
ARHGEF17	RASD2	ENSP00000263674	ENSP00000216127	Rho guanine nucleotide exchange factor (GEF) 17; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases	RASD family, member 2; GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected striatal competencies, mainly locomotor activity and motor coordination	0.757
ARHGEF17	TNS3	ENSP00000263674	ENSP00000312143	Rho guanine nucleotide exchange factor (GEF) 17; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases	tensin 3; May play a role in actin remodeling. Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Seems to be involved in mammary cell migration. May be involved in cell migration and bone development (By similarity)	0.703
CAPZA1	ANTXR1	ENSP00000263168	ENSP00000301945	capping protein (actin filament) muscle Z-line, alpha 1; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments	anthrax toxin receptor 1; Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells	0.474
CAPZA1	ARHGEF17	ENSP00000263168	ENSP00000263674	capping protein (actin filament) muscle Z-line, alpha 1; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments	Rho guanine nucleotide exchange factor (GEF) 17; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases	0.513
CAPZA1	CD248	ENSP00000263168	ENSP00000308117	capping protein (actin filament) muscle Z-line, alpha 1; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments	CD248 molecule, endosialin; May play a role in tumor angiogenesis	0.540
CAPZA1	GPR124	ENSP00000263168	ENSP00000406367	capping protein (actin filament) muscle Z-line, alpha 1; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments	G protein-coupled receptor 124; Endothelial receptor that acts as an essential regulator of CNS angiogenesis. Required for normal endothelial cell sprouting and migration in the forebrain and neural tube (By similarity)	0.764

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