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PTPN23 PTPN23 ENSG00000257390 ENSG00000257390 KDM2A KDM2A FBXL19 FBXL19 TRRAP TRRAP KDM2B KDM2B ZNF48 ZNF48 XRN1 XRN1 PLB1 PLB1 RANBP2 RANBP2 DNAJC14 DNAJC14
"ZNF48" - zinc finger protein 48 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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second shell of interactors
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experimentally determined
Predicted Interactions
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fusion edge
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textmining
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protein homology
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ZNF48zinc finger protein 48; May be involved in transcriptional regulation (618 aa)    
Predicted Functional Partners:
DNAJC14
DnaJ (Hsp40) homolog, subfamily C, member 14; Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface (By similarity) (702 aa)
            score_image   0.675
ENSG00000257390
Uncharacterized protein (523 aa)
            score_image   0.583
XRN1
5’-3’ exoribonuclease 1; Major 5’-3’ exoribonuclease involved in mRNA decay. Required for the 5’-3’-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS) (1706 aa)
      score_image score_image   score_image   0.543
PLB1
phospholipase B1; Membrane-associated phospholipase. Exhibits a calcium- independent broad substrate specificity including phospholipase A2/lysophospholipase activity. Preferential hydrolysis at the sn-2 position of diacylphospholipids and diacyglycerol, whereas it shows no positional specificity toward triacylglycerol. Exhibits also esterase activity toward p-nitrophenyl. May act on the brush border membrane to facilitate the absorption of digested lipids (By similarity) (1458 aa)
            score_image   0.514
KDM2A
lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] (1162 aa)
        score_image   score_image   0.501
FBXL19
F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) (694 aa)
        score_image   score_image   0.501
KDM2B
lysine (K)-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin [...] (1336 aa)
        score_image   score_image   0.501
TRRAP
transformation/transcription domain-associated protein; Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription acti [...] (3830 aa)
        score_image   score_image   0.488
PTPN23
protein tyrosine phosphatase, non-receptor type 23; May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis (1636 aa)
        score_image   score_image   0.476
RANBP2
RAN binding protein 2; E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Could also have isomerase or chaperone activity and may bind RNA or DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1. Sumoylates PML at ’Lys-490’ which is essential for the proper assembly of PML-NB (3224 aa)
        score_image   score_image   0.465
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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